Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
PZ HTL SA

MRI/NRS Technology Designed for Imaging Dense Breast Abnormalities

By BiotechDaily International staff writers
Posted on 04 Feb 2014
Image: Overview of the MRI/near-infrared spectroscopy (NIRS) system. The NIRS system is housed in the MRI control room (a) and light is piped into the MRI suite for patient imaging using fiber optic cables (b). A combined MRI/NIRS breast coil (c) makes simultaneous MRI and NIRS imaging possible (Photo courtesy of Norris Cotton Cancer Center).
Image: Overview of the MRI/near-infrared spectroscopy (NIRS) system. The NIRS system is housed in the MRI control room (a) and light is piped into the MRI suite for patient imaging using fiber optic cables (b). A combined MRI/NIRS breast coil (c) makes simultaneous MRI and NIRS imaging possible (Photo courtesy of Norris Cotton Cancer Center).
Engineers and radiologists are developing a new application for diagnostic imaging of dense breasts with suspicious lesions. The magnetic resonance imaging/near-infrared spectroscopy (MRI/NIRS) technique offers greater flexibility, speed, and accuracy than existing imaging modalities. The new technology also shows potential for enhancing MRI’s ability to differentiate cancer from benign abnormalities.

Combined MRI/NIRS may benefit women whose mammogram showed an abnormality and requires additional testing to rule out cancer. The scanning would be conducted before an invasive biopsy to search for tumors. For the new technology to perform effectively in routine patient care, MRI/NIRS must adapt to an individual’s body size as well as accommodate a range of cup sizes. The equipment must also mobilize and maintain contact with the breast.

An MRI/NIRS may provide certain advantages to women with dense breasts, who are more prone to develop and die from breast cancer. A dense breast is more difficult for a radiologist to “see through” when using standard imaging equipment, which lacks the sensitivity to penetrate the dense tissue. Conventional breast screening is effective 77%–97% of the time in a normal breast, but when a breast is dense precision falls to 63%–89%.

Earlier techniques for MRI/NIRS used parallel plates and required custom breast molds for each patient. Biomedical engineers developed a new, more flexible, convenient, and comfortable approach. They designed a set of eight light transmitting cables that can be adjusted to surround the breast with light tension. A woman lies on her stomach and the breast hangs suspended through the holes of the MRI/NIRS breast coil. The procedure is nearly the same as clinical MRI scanning.

Eight women participated in the study of this new design the findings of which were published in the February 2014 issue of Academic Radiology. “We found that the new interface allowed us to target lesions more effectively than ever before,” said Dr. Michael Mastanduno, from Geisel School of Medicine at Dartmouth University (Hanover, NH, USA) and corresponding author of the study. “Set up time was faster and images were of higher quality.”

The Dartmouth MRI/NIRS technology offers increased coverage of the chest, giving providers improved visibility for “hard to see” areas, such as the neighboring region of the breast near the armpit. “This work is a huge improvement on previous designs of MRI/NIRS systems. All breast sizes and lesion locations can now be effectively imaged. Though there is more work to be done, this technology is promising for improving MRI’s ability to distinguish cancer from benign abnormalities,” said Dr. Mastanduno.

In the next phase of the study, Dartmouth researchers will assess MRI/NIRS in women with suspicious lesions.

Related Links:

Geisel School of Medicine at Dartmouth University



comments powered by Disqus

Channels

Genomics/Proteomics

view channel

New Program Encourages Wide Distribution of Genomic Data

A new data sharing program allows genomics researchers and practitioners to analyze, visualize, and share raw sequence data for individual patients or across populations straight from a local browser. The sequencing revolution is providing the raw data required to identify the genetic variants underlying rare diseases... Read more

Drug Discovery

view channel
Image: The nano-cocoon drug delivery system is biocompatible, specifically targets cancer cells, can carry a large drug load, and releases the drugs very quickly once inside the cancer cell. Ligands on the surface of the \"cocoon\" trick cancer cells into consuming it. Enzymes (the “worms\" in this image) inside the cocoon are unleashed once inside the cell, destroying the cocoon and releasing anticancer drugs into the cell (Photo courtesy of Dr. Zhen Gu, North Carolina State University).

Novel Anticancer Drug Delivery System Utilizes DNA-Based Nanocapsules

A novel DNA-based drug delivery system minimizes damage to normal tissues by utilizing the acidic microenvironment inside cancer cells to trigger the directed release of the anticancer drug doxorubicin (DOX).... Read more

Lab Technologies

view channel

Experimental Physicists Find Clues into How Radiotherapy Kills Cancer Cells

A new discovery in experimental physics has implications for a better determination of the process in which radiotherapy destroys cancer cells. Dr. Jason Greenwood from Queen’s University Belfast (Ireland) Center for Plasma Physics collaborated with scientists from Italy and Spain on the work on electrons, and published... Read more

Business

view channel

Interest in Commercial Applications for Proteomics Continues to Grow

Increasing interest in the field of proteomics has led to a series of agreements between private proteomic companies and academic institutions as well as deals between pharmaceutical companies and novel proteomics innovator biotech companies. Proteomics is the study of the structure and function of proteins.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.