Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
PZ HTL SA
GLOBETECH PUBLISHING LLC

New Nanomaterial Promises Enhanced Detection and Treatment of Breast Cancer

By BiotechDaily International staff writers
Posted on 07 Jan 2014
Image: Muonium [an exotic atom made up of an antimuon and an electron] trapped inside a buckyball. Muons provide a complementary probe to neutrons, particularly in the areas of magnetism, superconductivity, and charge transport (Photo courtesy of ISIS).
Image: Muonium [an exotic atom made up of an antimuon and an electron] trapped inside a buckyball. Muons provide a complementary probe to neutrons, particularly in the areas of magnetism, superconductivity, and charge transport (Photo courtesy of ISIS).
A collaboration of scientists from the United Kingdom, Denmark, Brazil, and Germany are devising new detection and treatment technology for breast cancer patients.

The study’s findings were published December 2013 in the Journal of Alloys and Compounds. Current diagnostic methods such as mammograms can only detect between 65% and 95% of tumors, and developing better ways of detection is of prime urgency. If not detected and treated early enough, breast cancer can spread to other areas of the body, increasing the probability that the disease will become lethal.

The team of scientists has been using the Polaris instrument at the ISIS pulsed neutron and muon source at the Rutherford Appleton Laboratory (Harwell Oxford, UK) to develop a new bio-nanocomposite that they hope will eventually lead to earlier detection, and more successful treatment, of breast cancer. The new substance exploits the fact that cancer cells attract a molecule called hydroxyapatite, which is a component of bones. The researchers are developing magnetic nanoparticles coated with a biocompatible polymer that includes hydroxyapatite nanocrystals. When administered into the body, these nanoparticles should travel right to cancer cells, and once they do, they make it much easier to detect the tumor on an MRI scan.

Not only do the nanoparticles help to identify tumors, but they may also help to block the metastasis to other areas of the body, as hydroxyapatite is known to suppress that facet of tumor activity.

The next phase of study is to incorporate antitumor agents into the nanoparticles. The magnetic nature of the nanoparticles means that they can be directed to the site of the tumor by using magnets outside of the body. If antitumor drugs can be added to the nanoparticles, then they can be used to deliver the treatment directly to the tumor, optimizing the effectiveness of the treatment and reducing the risk of harmful side effects--imagine a fleet of tiny drones, delivering anticancer weapons right where they are needed.

This research is at a very early stage, and far more study is required, according to the scientists, before it can be developed into a treatment option.

ISIS generates beams of neutrons and muons that allow scientists to study materials at the atomic level using a suite of instruments, frequently described as super-microscopes. It supports a national and international community of more than 2,000 scientists who use neutrons and muons for research in physics, chemistry, materials science, geology, engineering, and biology.

Related Links:

ISIS



comments powered by Disqus

Channels

Genomics/Proteomics

view channel

New Program Encourages Wide Distribution of Genomic Data

A new data sharing program allows genomics researchers and practitioners to analyze, visualize, and share raw sequence data for individual patients or across populations straight from a local browser. The sequencing revolution is providing the raw data required to identify the genetic variants underlying rare diseases... Read more

Drug Discovery

view channel
Image: The nano-cocoon drug delivery system is biocompatible, specifically targets cancer cells, can carry a large drug load, and releases the drugs very quickly once inside the cancer cell. Ligands on the surface of the \"cocoon\" trick cancer cells into consuming it. Enzymes (the “worms\" in this image) inside the cocoon are unleashed once inside the cell, destroying the cocoon and releasing anticancer drugs into the cell (Photo courtesy of Dr. Zhen Gu, North Carolina State University).

Novel Anticancer Drug Delivery System Utilizes DNA-Based Nanocapsules

A novel DNA-based drug delivery system minimizes damage to normal tissues by utilizing the acidic microenvironment inside cancer cells to trigger the directed release of the anticancer drug doxorubicin (DOX).... Read more

Lab Technologies

view channel

Experimental Physicists Find Clues into How Radiotherapy Kills Cancer Cells

A new discovery in experimental physics has implications for a better determination of the process in which radiotherapy destroys cancer cells. Dr. Jason Greenwood from Queen’s University Belfast (Ireland) Center for Plasma Physics collaborated with scientists from Italy and Spain on the work on electrons, and published... Read more

Business

view channel

Interest in Commercial Applications for Proteomics Continues to Grow

Increasing interest in the field of proteomics has led to a series of agreements between private proteomic companies and academic institutions as well as deals between pharmaceutical companies and novel proteomics innovator biotech companies. Proteomics is the study of the structure and function of proteins.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.