Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

MR Research Reveals Altered Brain Connections in Epilepsy Patients

By BiotechDaily International staff writers
Posted on 12 Dec 2013
Image: Flowchart illustrates the steps of the connectivity analysis. MP-RAGE (magnetization-prepared rapid acquisition gradient echo) volumes are segmented into 83 region of interest (ROIs), which are further parcellated into 1,000 cortical and 15 subcortical ROIs. Whole-brain white matter tractography is performed after voxelwise tensor calculation, and the density of fibers that connect each pair of cortical ROIs is used to calculate structural connectivity. T1w = T1-weighted (Photo courtesy of RSNA).
Image: Flowchart illustrates the steps of the connectivity analysis. MP-RAGE (magnetization-prepared rapid acquisition gradient echo) volumes are segmented into 83 region of interest (ROIs), which are further parcellated into 1,000 cortical and 15 subcortical ROIs. Whole-brain white matter tractography is performed after voxelwise tensor calculation, and the density of fibers that connect each pair of cortical ROIs is used to calculate structural connectivity. T1w = T1-weighted (Photo courtesy of RSNA).
Image: Surface representation shows the gray-white matter junction of the seven modules that emerge by using the Newman spectral algorithm on an across-subject (both healthy subjects and patients with temporal lobe epilepsy [TLE]) average connectivity matrix (Photo courtesy of RSNA).
Image: Surface representation shows the gray-white matter junction of the seven modules that emerge by using the Newman spectral algorithm on an across-subject (both healthy subjects and patients with temporal lobe epilepsy [TLE]) average connectivity matrix (Photo courtesy of RSNA).
Image: Inflated cortical surface representations show the significant (p  the group of patients with TLE and healthy subjects. Warm colors (red, orange, and yellow) indicate increases in TLE, while cool colors (blue) indicate decreases. Within-module connectivity is within-module z score of degree, and between-module connectivity is participation coefficient. Light gray areas represent gyri, and dark gray areas represent sulci. Lat = lateral, Med = medial (Photo courtesy of RSNA).
Image: Inflated cortical surface representations show the significant (p the group of patients with TLE and healthy subjects. Warm colors (red, orange, and yellow) indicate increases in TLE, while cool colors (blue) indicate decreases. Within-module connectivity is within-module z score of degree, and between-module connectivity is participation coefficient. Light gray areas represent gyri, and dark gray areas represent sulci. Lat = lateral, Med = medial (Photo courtesy of RSNA).
New imaging findings show that patients with the most typical form of focal epilepsy have widespread, abnormal connections in their brains. This new research could provide insights for better diagnosis and treatment of the disorder.

The study’s findings were published online November 19, 2013, in the journal Radiology. Temporal lobe epilepsy (TLE) is characterized by seizures originating from the temporal lobes. Clinicians at first believed that the disorder was related to isolated injuries of structures within the temporal lobe, such as the hippocampus. However, recent research has implicated the default mode network (DMN), the set of brain regions activated during task-free introspection and deactivated during goal-directed behavior. The DMN consists of several hubs that are more active during the resting state.

Researchers performed diffusion tensor imaging—a type of magnetic resonance imaging (MRI) technology that monitors the diffusion of water in the brain’s white matter—of the nerve fibers that send signals throughout the brain to analyze the patients. The study group consisted of 24 patients with left temporal lobe epilepsy who were scheduled for surgery to remove the site from where their seizures emanated. The researchers compared them with 24 healthy controls using an MRI protocol designed to find white matter tracts with diffusion imaging at high resolution. The data were studied with a new technique that identifies and quantifies structural connections in the brain.

Patients with left temporal lobe epilepsy showed a drop in long-range connectivity of 22%–45% among areas of the DMN when compared with the healthy controls. “Using diffusion MRI, we found alterations in the structural connectivity beyond the medial temporal lobe, especially in the default mode network,” said Steven M. Stufflebeam, MD, from the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital (Boston, MA, USA).

In addition to reduced long-range connectivity, the epileptic patients had an 85%–270% increase in local connectivity within and beyond the DMN. The researchers believe this may be an adaptation to the loss of the long-range connections. “The increase in local connections could represent a maladaptive mechanism by which overall neural connectivity is maintained despite the loss of connections through important hub areas,” Dr. Stufflebeam said.

The findings are supported by earlier functional MRI scans that have shown decreased functional connectivity in DMN areas in temporal lobe epilepsy. Researchers are not sure if the structural changes cause the functional changes, or the opposite. “It’s probably a breakdown of myelin, which is the insulation of neurons, causing a slowdown in the propagation of information, but we don’t know for sure,” Dr. Stufflebeam said.

Dr. Stufflebeam and colleagues plan to continue their research, using structural and functional MRI with electroencephalography and magnetoencephalography to monitor diffusion changes and visualize real-time brain activity. “Our long-term goal is to see if we can we predict from diffusion studies who will respond to surgery and who will not,” he said.

The study is part of the Human Connectome Project, a five-year project funded by the National Institutes of Health that uses neuroimaging techniques to study connectomics, or the functional and structural connections in the brain.

Related Links:

Massachusetts General Hospital




comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: Diagram illustrates the innovative process that could lead to more effective drugs against influenza infection (Photo courtesy of the Hebrew University of Jerusalem).

Researchers Show How the Influenza Virus Blocks Natural Killer Cell Recognition

A team of molecular virologists has described how the influenza virus evolved a defense mechanism to protect it from attack by the immune system's natural killer (NK) cells. The recognition of pathogen-infected... Read more

Drug Discovery

view channel
Image: Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells (Photo courtesy of the University of Texas, Austin).

Experimental Drug Kills Cancer Cells by Interfering with Their Ion Transport Mechanism

An experimental anticancer drug induces cells to enter a molecular pathway leading to apoptosis by skewing their ion transport systems to greatly favor the influx of chloride anions. To promote development... Read more

Therapeutics

view channel
Image: Liver cells regenerated in mice treated with a new drug (right) compared with a control group (center) after partial liver removal. Healthy liver cells are shown at left (Photo courtesy of Marshall et al, 2014, the Journal of Experimental Medicine).

New Drug Triggers Liver Regeneration After Surgery

Investigators have revealed that an innovative complement inhibitor decreases complement-mediated liver cell death, and actually stimulates postsurgery liver regrowth in mice. Liver cancer often results... Read more

Lab Technologies

view channel

Genome-Wide Mutation-Searching Computational Software Designed for Genomic Medicine

Analysis software cross-references a patient’s symptoms with his genome sequence to help physicians in the diagnosis of disease. This software was created by a team of scientists from A*STAR’s Genome Institute of Singapore (GIS), led by Dr. Pauline Ng. The research findings were published August 3, 2014, in the journal... Read more

Business

view channel

Partnership Established to Decode Bowel Disease

23andMe (Mountain View, CA,USA), a personal genetics company, is collaborating with Pfizer, Inc. (New York, NY, USA), in which the companies will seek to enroll 10,000 people with inflammatory bowel disease (IBD) in a research project designed to explore the genetic factors associated with the onset, progression, severity,... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.