Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

06 Jun 2016 - 09 Jun 2016
22 Jun 2016 - 24 Jun 2016
04 Jul 2016 - 06 Jul 2016

Regenerative Medicine Aided by Nanotechnology Strategies

By BiotechDaily International staff writers
Posted on 19 Nov 2013
Print article
Nanotechnology may provide new approaches for regenerative medicine, including better ways to restore or enhance damaged tissues, according to a review article by Taiwanese researchers.

Published October 2013 in the journal Science and Technology of Advanced Materials, the study reported on the current state of knowledge on nanotechnology with a focus on stem cell biology applications. Stem cells are an important potential source for repairing injured human tissues. Researchers have found that the adhesion, growth, and differentiation of stem cells are most probably controlled by their surrounding microenvironment, which contains both physical and chemical signals. These signals include the “nanotopography” of the complicated extracellular matrix that comprises a network for human tissues.

Dr. Yang-Kao Wang and colleagues from Taipei Medical University (Taipei City, Taiwan) described in their article studies showing how this nanotopography (which includes nanosized pores, ridges, and grooves) plays critical roles in the behavior and fate of stem cells. The authors also discussed the application of nanoparticles to stem cell isolation, tracking and imaging; how to convert nanotechnology tools from two to three dimensions; and the potential limitations of using nanomaterials in stem cell biology.

The authors concluded that “understanding [the] interactions of nanomaterials with stem cells may provide knowledge applicable to [the development of improved] cell-scaffold combinations in tissue engineering and regenerative medicine.”

Related Links:

Taipei Medical University



Print article

Channels

Genomics/Proteomics

view channel
Image: Follicular helper T-cells (TFH cells, shown in blue) play a crucial role in the maturation of antibody-producing B-cells (shown in green). Activated B-cells give rise germinal centers (shown in red), where mature B-cells proliferate and produce highly specific antibodies against pathogens. Top left: normal germinal center in a mouse tonsil. All others: Germinal centers fail to form when the interaction between ICOS and TBK1 is interrupted (Photo courtesy of Dr. Kok-Fai Kong, La Jolla Institute for Allergy and Immunology).

Molecular Pathway Controlling High-affinity Antibody Production Identified

A molecular pathway has been identified that controls formation of follicular helper T-cells (TFH cells) germinal centers and production of high-affinity antibodies through interaction with the inducible... Read more

Drug Discovery

view channel

Experimental Small-Molecule Anticancer Drug Blocks RAS-binding Domains

The experimental small-molecule anticancer drug rigosertib was shown to block tumor growth by acting as an RAS-mimetic and interacting with the RAS binding domains of RAF kinases, resulting in their inability to bind to RAS, which inhibited the RAS-RAF-MEK pathway. Oncogenic activation of RAS genes due to point mutations... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Business

view channel

European Biotech Agreement to Promote Antigen-Drug Conjugation Technology

Two European biotech companies have joined forces to exploit and commercialize an innovative, site-specific ADC (antigen-drug conjugate) conjugation technology. ProBioGen (Berlin, Germany), a company specializing in the development and manufacture of complex glycoproteins and Eucodis Bioscience (Vienna, Austria), a... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.