Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
PURITAN MEDICAL

Programming Language Designed to Construct Synthetic DNA

By BiotechDaily International staff writers
Posted on 24 Oct 2013
Image: An artist’s rendering shows DNA structures and a chemical reaction “program” on the screen. A “chemical computer” executes the molecular program (Photo courtesy of Yan Liang, L2XY2.com).
Image: An artist’s rendering shows DNA structures and a chemical reaction “program” on the screen. A “chemical computer” executes the molecular program (Photo courtesy of Yan Liang, L2XY2.com).
Image: An example of a chemical program. Here, A, B, and C are different chemical species (Photo courtesy of Yan Liang, L2XY2.com).
Image: An example of a chemical program. Here, A, B, and C are different chemical species (Photo courtesy of Yan Liang, L2XY2.com).
Chemists and biotech researchers may soon be able to use a structured series of instructions to “program” how DNA molecules interact in a test tube or cell, similar to using a programming language to write computer code.

A team of investigators, led by the University of Washington (UW; Seattle, USA), has developed a programming language for chemistry that it hopes will streamline efforts to design a network that can guide the behavior of chemical-reaction amalgams in the same manner that embedded electronic controllers guide robots, cars, and other devices. In medicine, such networks could serve as “smart” drug deliverers or disease detectors at the cellular level.

The study’s findings were published online September 29, 2013, in the journal Nature Nanotechnology. Chemists and educators teach and use chemical reaction networks, 100-year-old language of equations that describes how mixtures of chemicals behave. The UW engineers take this language an additional step and use it to write programs that direct the movement of customized molecules.

“We start from an abstract, mathematical description of a chemical system, and then use DNA to build the molecules that realize the desired dynamics,” said corresponding author Dr. Georg Seelig, a UW assistant professor of electrical engineering and of computer science and engineering. “The vision is that eventually, you can use this technology to build general-purpose tools.”

Currently, when a biologist or chemist makes a specific type of molecular network, the engineering process is complicated, cumbersome, and difficult to repurpose for constructing other systems. The UW engineers wanted to devise a framework that gives scientists more flexibility. Dr. Seelig compares this new approach to programming languages that tell a computer what to do. “I think this is appealing because it allows you to solve more than one problem,” he said. “If you want a computer to do something else, you just reprogram it. This project is very similar in that we can tell chemistry what to do.”

Humans and other organisms already have complex networks of nano-sized molecules that help to control cells and keep the body in line. Scientists now are finding ways to design synthetic systems that behave similar to biologic ones with the hope that synthetic molecules could support the body’s natural functions. To achieve this, a system is needed to create synthetic DNA molecules that vary according to their specific functions.

The new application is not yet ready to be utilized in medicine, but future uses could include using this framework to make molecules that self-assemble within cells and serve as “smart” sensors. These could be embedded in a cell, then programmed to identify abnormalities and respond as required, possibly by delivering drugs directly to those cells.

Drs. Seelig and colleague Eric Klavins, a UW associate professor of electrical engineering, recently received USD 2 million from the National Science Foundation (Washington DC, USA) as part of a national initiative to enhance research in molecular programming. The new language will be used to support that larger initiative, according to Dr. Seelig.

Related Links:

University of Washington



Channels

Genomics/Proteomics

view channel
Image: The photomicrograph shows the head of a mouse embryo in which the pericytes are visible as blue dots along the blood vessel (Photo courtesy of the University of Gothenburg).

Genetically Engineered Mouse Model Reveals Key to Formation of the Blood-Brain Barrier

Use of a mouse model that had been genetically engineered to lack the gene that encodes the forkhead transcription factor Foxf2 has helped to explain how pericytes, cells that line the capillaries, form... Read more

Drug Discovery

view channel
Image: Scanning electron microscope (SEM) image of a field of polypyrrole nanowires (Photo courtesy of Dr. Richard Borgens, Purdue University).

Novel Controlled-Release Drug Delivery System Heals Spinal Inflammation in Mouse Model

A novel drug delivery system that allows controllable release of an anti-inflammatory agent directly to the site of inflammation or injury was tested successfully in a mouse model. Investigators at... Read more

Business

view channel

Biopharm Startup to Commercialize Antibody Therapy for Drug Resistant Cancers

A biopharm startup company has licensed the rights to commercialize an antibody-based approach for treatment of drug resistant cancers. The new company, CadheRx Therapeutics (La Jolla, CA, USA), entered into a licensing agreement with Stony Brook University (NY, USA) to develop and market an anticancer technology derived... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.