Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Novel Anti-PTEN Rabbit Monoclonal Antibody Optimized for Immunohistochemistry Testing

By BiotechDaily International staff writers
Posted on 16 Sep 2013
Print article
Image: SP218 staining PTEN loss on colon adenocarcinoma sample (Photo courtesy of Spring Bioscience, Inc.).
Image: SP218 staining PTEN loss on colon adenocarcinoma sample (Photo courtesy of Spring Bioscience, Inc.).
Cancer researchers now have available a rabbit monoclonal antibody for the protein produced by the PTEN tumor suppressor gene that has been optimized for immunohistochemistry (IHC) testing.

PTEN is one of the most commonly lost tumor suppressors in human cancer. During tumor development, mutations and deletions of PTEN occur that inactivate its enzymatic activity leading to increased cell proliferation and reduced cell death. Frequent genetic inactivation of PTEN occurs in glioblastoma, endometrial cancer, prostate cancer, and reduced expression is found in many other tumor types such as lung and breast cancer. When the PTEN enzyme is functioning properly, it acts as part of a chemical pathway that signals cells to stop dividing and causes cells to undergo programmed cell death (apoptosis) when necessary. These functions prevent uncontrolled cell growth that can lead to the formation of tumors. There is also evidence that the protein made by the PTEN gene may play a role in both cell movement and adhesion of cells to surrounding tissues.

A new tool for the study the PTEN enzyme was developed by Spring Bioscience (Pleasanton, CA, USA). Spring has recently added the SP218 anti-PTEN rabbit monoclonal antibody to its portfolio of antibodies for cancer research.

The SP218 anti-PTEN monoclonal antibody for IHC on FFPE (formalin-fixed, paraffin-embedded) tissue is available in 0.1, 0.5, and 1.0 mL concentrate configurations, as well as in a 7.0-mL ready-to-use format. Recommended staining protocols are available for manual, semi-automated, and fully automated platforms. SP218 is for research use only and not for use in diagnostic procedures.

"SP218's robust and consistent performance with IHC analysis is particularly important given PTEN's potential as a companion diagnostic biomarker," said Michael Rivers, general manager of Spring Bioscience. "With SP218, we are seeking to set a new gold standard across the industry by offering an extremely sensitive, highly specific antibody optimized for IHC testing that will allow researchers and pathologists to interpret PTEN status with utmost confidence. For our customers, this means we are continuing to offer unparalleled value through superior tests that lead the market in innovation, reliability, and quality."

Related Links:
Spring Bioscience



Print article

Channels

Genomics/Proteomics

view channel
Image: Healthy blood cells along with sickle-cell diseased cells (Photo courtesy of Science Picture Co./Corbis).

Gene Editing Corrects Hemoglobin Defects in Beta-Thalassemia and Sickle Cell Disease

A team of hematology researchers used the CRISPR/Cas9 gene editing technique to correct the mutations that cause defective blood cell morphology in beta-thalassemia and sickle cell disease.... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Business

view channel

Collaborative Agreement to Aid in Setting Guidelines for Evaluating Potential Ebola Therapy

Cooperation between an Israeli biopharmaceutical company and medical branches of the US government is designed to set ground rules for continued evaluation of an experimental therapy for Ebola virus disease. RedHill Biopharma Ltd. (Tel Aviv, Israel), a biopharmaceutical company primarily focused on development and c... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.