Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

10 Oct 2016 - 12 Oct 2016
12 Nov 2016 - 16 Nov 2016

Different Bacteria Cultures Maintained in Microfluidic System

By BiotechDaily International staff writers
Posted on 13 Aug 2013
Print article
Image: Microfluidic system for multiple bacterial cultures (Photo courtesy of Polish Institute of Physical Chemistry).
Image: Microfluidic system for multiple bacterial cultures (Photo courtesy of Polish Institute of Physical Chemistry).
A fabricated microfluidic device allows hundreds of different bacteria cultures to be maintained simultaneously.

The system allows for the merging, transporting and splitting of microdroplets where strictly controlled chemical reactions and the cultivation of bacterial colonies can be performed.

A group of scientists at the Institute of Physical Chemistry (Warsaw, Poland) engineered the microfluidic systems from polymer plates that correspond to the size of a credit card. Inside the system, a carrier fluid, mostly oil, carries microdroplets containing chemicals, flows laminarly through tiny channels of diameters in the range of tenths or hundredths of a millimeter. In this single microfluidic system thousands of different chemical reactions can be carried out during a day.

The microsystem is composed of two branches of microchannels forming densely arranged zigzags. A few hundred droplets can circulate in the microchannels, at a distance of about one centimeter from each other. The microdroplets move in a pendular movement from one branch to the other. Each droplet circulating within the microfluidic system has its own unique identifier, assigned by the optoelectronic system. It allows the scientist to monitor at any time what operations have been carried out on each microdroplet. A single droplet can include over 100,000 bacteria that are unable to move between the droplets, as the bacteria cannot cross the surface membrane of a microdroplet, and the carrier liquid used to transport microdroplets is not an environment favorable for the life of bacteria.

Piotr Garstecki, PhD, DSc, the lead author, said, “We can transform each microdroplet into a real bioreactor. Therefore, in a single small plate we can have up to several hundreds of bioreactors, with different, controlled concentration of an antibiotic, a different antibiotic or even different bacterial species in each bioreactor.” The paper was published on July 15, 2013, in the journal Angewandte Chemie International Edition.

Related Links:

Polish Institute of Physical Chemistry



Print article

Channels

Drug Discovery

view channel
Image: Ginger is the source of a novel class of nanolipid transport vector (Photo courtesy of Georgia State University).

Ginger-Derived Doxorubicin-Loaded Nanovectors as Drug Delivery for Cancer Therapy

A novel type of nanoparticle drug transport system based on lipids isolated from ginger was used to deliver the toxic chemotherapeutic agent doxorubicin (Dox) to colon cancer cells with minimal damage... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Business

view channel

Collaborative Agreement to Aid in Setting Guidelines for Evaluating Potential Ebola Therapy

Cooperation between an Israeli biopharmaceutical company and medical branches of the US government is designed to set ground rules for continued evaluation of an experimental therapy for Ebola virus disease. RedHill Biopharma Ltd. (Tel Aviv, Israel), a biopharmaceutical company primarily focused on development and c... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.