Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
PZ HTL SA
GLOBETECH PUBLISHING

Prototype Microspectrometer Suitable for Lab-on-a-Chip Technologies

By BiotechDaily International staff writers
Posted on 12 Aug 2013
Image: Yale University researchers have developed an ultracompact, low-cost spectrometer with improved resolution over existing micro models. The innovation represents an advance in “lab-on-a-chip” technology, or the consolidation of laboratory capabilities in miniature, highly portable devices (Photo courtesy of Yale University).
Image: Yale University researchers have developed an ultracompact, low-cost spectrometer with improved resolution over existing micro models. The innovation represents an advance in “lab-on-a-chip” technology, or the consolidation of laboratory capabilities in miniature, highly portable devices (Photo courtesy of Yale University).
By passing a beam of light through a silicon chip pierced with randomly scattered holes investigators have developed a sensitive microspectrometer that may be adaptable for "lab-on-a-chip" applications.

Investigators at Yale University (New Haven, CT, USA) reported in the July 28, 3013, online edition of the journal Nature Photonics that they had built a spectrometer based on multiple light scattering in a silicon-on-insulator chip featuring a random structure. A probe signal diffused through the chip generating wavelength-dependent speckle patterns, which were detected and used to recover the input spectrum after calibration. A spectral resolution of 0.75 nanometers at a wavelength of 1,500 nanometers in a 25-micrometer-radius structure was achieved.

“The largest dimension of our spectrometer, which we built on a silicon chip, is about the width of a human hair,” said first author Dr. Brandon Redding, a postdoctoral associate in applied physics at Yale University. “It could open up a whole new range of uses, a lot of them outside the lab.”

The microspectrometer can detect a change in wavelength of less than one nanometer, roughly matching the capability of macroscopic spectrometers about the size of a hard drive. “We were taking a very different approach,” said Dr. Redding. “The idea of using disorder and multiple scattering is a fairly unexplored concept. Normally, disorder is something you want to overcome or avoid. In this case, it is what lets us make the device so small. We get a much longer path length for our light relative to the size of the device, because the light bounces around many times.”

The authors maintain that a compact, high-resolution spectrometer, such as that described in this study, is well suited for lab-on-a-chip spectroscopy applications.

Related Links:

Yale University




Channels

Genomics/Proteomics

view channel
Image: The TheraCyte cell encapsulation device (Photo courtesy of TheraCyte, Inc.).

Encapsulated Human-Insulin-Producing Progenitor Cells Cure Diabetes in Mouse Model

A breakthrough system that allows subcutaneous implantation of encapsulated immature pancreatic cells (beta progenitor cells) was shown to produce enough insulin to correct the symptoms of diabetes in a mouse model.... Read more

Drug Discovery

view channel
Image: Chitosan is derived from the shells of shrimp and other sea crustaceans, including Alaskan pink shrimp, pictured here (Photo courtesy of NOAA - [US] National Oceanic and Atmospheric Administration).

Chitosan Treatment Clears the Way for Antibiotics to Eliminate Recurrent Urinary Tract Infections

Recurrent urinary tract infection was successfully resolved in a mouse model by treatment with the exfoliant chitosan followed by a round of antibiotics. Bacterial urinary tract infection (UTI), most... Read more

Biochemistry

view channel

Mitochondrial Cause of Aging Can Be Reversed

Researchers have found a cause of aging in lab animals that can be reversed, possibly providing an avenue for new treatments for age-related diseases including type 2 diabetes, cancer, muscle wasting, and inflammatory diseases. The researchers plan to begin human trials late 2014. The study, which was published December... Read more

Therapeutics

view channel

Cytokine Identified That Causes Mucositis in Cancer Therapy Patients

The action of the cytokine interleukin 1-beta (IL-1beta) has been found to underlie the onset of mucositis, a common, severe side effect of chemotherapy and irradiation of cancer patients. Mucositis occurs as a result of cell death in reaction to chemo- or radiotherapy. The mucosal lining of the mouth becomes thin, may... Read more

Business

view channel

Analytical Sciences Trade Fair Declared a Rousing Success

Organizers of this year's 24th "analytica" biosciences trade fair have reported significant increases in both the number of visitors and exhibitors compared to the 2012 event. The analytica trade fair for laboratory technology, analysis, and biotechnology has been held at the Munich (Germany) Trade Fair Center every... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.