Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
BioConferenceLive

Prototype Microspectrometer Suitable for Lab-on-a-Chip Technologies

By BiotechDaily International staff writers
Posted on 12 Aug 2013
Image: Yale University researchers have developed an ultracompact, low-cost spectrometer with improved resolution over existing micro models. The innovation represents an advance in “lab-on-a-chip” technology, or the consolidation of laboratory capabilities in miniature, highly portable devices (Photo courtesy of Yale University).
Image: Yale University researchers have developed an ultracompact, low-cost spectrometer with improved resolution over existing micro models. The innovation represents an advance in “lab-on-a-chip” technology, or the consolidation of laboratory capabilities in miniature, highly portable devices (Photo courtesy of Yale University).
By passing a beam of light through a silicon chip pierced with randomly scattered holes investigators have developed a sensitive microspectrometer that may be adaptable for "lab-on-a-chip" applications.

Investigators at Yale University (New Haven, CT, USA) reported in the July 28, 3013, online edition of the journal Nature Photonics that they had built a spectrometer based on multiple light scattering in a silicon-on-insulator chip featuring a random structure. A probe signal diffused through the chip generating wavelength-dependent speckle patterns, which were detected and used to recover the input spectrum after calibration. A spectral resolution of 0.75 nanometers at a wavelength of 1,500 nanometers in a 25-micrometer-radius structure was achieved.

“The largest dimension of our spectrometer, which we built on a silicon chip, is about the width of a human hair,” said first author Dr. Brandon Redding, a postdoctoral associate in applied physics at Yale University. “It could open up a whole new range of uses, a lot of them outside the lab.”

The microspectrometer can detect a change in wavelength of less than one nanometer, roughly matching the capability of macroscopic spectrometers about the size of a hard drive. “We were taking a very different approach,” said Dr. Redding. “The idea of using disorder and multiple scattering is a fairly unexplored concept. Normally, disorder is something you want to overcome or avoid. In this case, it is what lets us make the device so small. We get a much longer path length for our light relative to the size of the device, because the light bounces around many times.”

The authors maintain that a compact, high-resolution spectrometer, such as that described in this study, is well suited for lab-on-a-chip spectroscopy applications.

Related Links:

Yale University




comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: In the liver tissue of obese animals with type II diabetes, unhealthy, fat-filled cells are prolific (small white cells, panel A). After chronic treatment through FGF1 injections, the liver cells successfully lose fat and absorb sugar from the bloodstream (small purple cells, panel B) and more closely resemble cells of normal, non-diabetic animals (Photo courtesy of the Salk Institute for Biological Studies).

Fibroblast Growth Factor 1 Treatment Restores Glucose Control in Mouse Diabetes Model

A "vaccine" based on the metabolic regulator fibroblast growth factor 1 (FGF1) removed the insulin resistance that characterizes type II diabetes and restored the body's natural ability to manage its glucose... Read more

Drug Discovery

view channel
Image: Molecular rendering of the crystal structure of parkin (Photo courtesy of Wikimedia Commons).

Cinnamon Feeding Blocks Development of Parkinson's Disease in Mouse Model

A team of neurological researchers has identified a molecular mechanism by which cinnamon acts to protect neurons from damage caused by Parkinson's disease (PD) in a mouse model of the syndrome.... Read more

Therapeutics

view channel
Image: This type of electronic pacemaker could become obsolete if induction of biological pacemaker cells by gene therapy proves successful (Photo courtesy of Wikimedia Commons).

Gene Therapy Induces Functional Pacemaker Cells in Pig Heart Failure Model

Cardiovascular disease researchers working with a porcine heart failure model have demonstrated the practicality of using gene therapy to replace implanted electronic pacemakers to regulate heartbeat.... Read more

Business

view channel

Cancer Immunotherapy Sector Predicted to Surge to USD 9 Billion Across Major Pharma Through 2022

The immunotherapy market will experience substantial growth through 2022, increasing from USD 1.1 billion in 2012 to nearly USD 9 billion in 2022 (corresponding to 23.8% annual growth) in the United Kingdom, United States, France, Germany, Italy, Spain, and Japan, according to recent market research. This notable growth... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.