Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

25 May 2016 - 27 May 2016
06 Jun 2016 - 09 Jun 2016
22 Jun 2016 - 24 Jun 2016

New Imaging Technology Accelerates Multiple Sclerosis Research

By BiotechDaily International staff writers
Posted on 09 Jul 2013
Print article
Image: A frequency-based MRI image of an MS patient shows changes in tissue structure (Photo courtesy of the University of British Columbia).
Image: A frequency-based MRI image of an MS patient shows changes in tissue structure (Photo courtesy of the University of British Columbia).
Canadian investigators have developed a new magnetic resonance imaging (MRI) technique that detects the characteristic signs of multiple sclerosis in finer detail than ever before, providing a more effective tool for evaluating new treatments.

The technique analyzes the frequency of electromagnetic waves collected by an MRI scanner, instead of the actual wave size. Although analyzing the number of waves per second had been considered a more sensitive way of identifying changes in tissue structure, the calculations required to generate usable images had been problematic.

Multiple sclerosis (MS) occurs when an individual’s immune cells attack the protective insulation, known as myelin, which surrounds nerve fibers. The degrading process of myelin hinders the electrical signals transmitted between neurons, resulting in a range of symptoms, including numbness or weakness, vision loss, tremors, fatigue, and dizziness.

Dr. Alexander Rauscher, an assistant professor of radiology, and graduate student Vanessa Wiggerman in the University of British Columbia (UBC) MRI Research Center (Vancouver, BC, Canada), analyzed the frequency of MRI brain scans. With Dr. Anthony Traboulsee, an associate professor of neurology and director of the UBC Hospital MS Clinic, they applied their method to 20 MS patients, who were scanned once a month for six months using both conventional MRI and the new frequency-based method.

Once scars in the myelin (lesions) appeared in conventional MRI scans, Dr. Rauscher and his colleagues went back to earlier frequency-based images of those patients. Looking in the precise areas of those lesions, they found frequency alterations representing tissue damage at least two months before any sign of damage appeared on conventional scans. The results were published according to research published in the June 12, 2013, issue of the journal Neurology, the medical journal of the American Academy of Neurology.

“This technique teases out the subtle differences in the development of MS lesions over time,” Dr. Rauscher concluded. “Because this technique is more sensitive to those changes, researchers could use much smaller studies to determine whether a treatment, such as a new drug, is slowing or even stopping the myelin breakdown.”

Related Links:
University of British Columbia MRI Research Center


Print article

Channels

Genomics/Proteomics

view channel
Image: Follicular helper T-cells (TFH cells, shown in blue) play a crucial role in the maturation of antibody-producing B-cells (shown in green). Activated B-cells give rise germinal centers (shown in red), where mature B-cells proliferate and produce highly specific antibodies against pathogens. Top left: normal germinal center in a mouse tonsil. All others: Germinal centers fail to form when the interaction between ICOS and TBK1 is interrupted (Photo courtesy of Dr. Kok-Fai Kong, La Jolla Institute for Allergy and Immunology).

Molecular Pathway Controlling High-affinity Antibody Production Identified

A molecular pathway has been identified that controls formation of follicular helper T-cells (TFH cells) germinal centers and production of high-affinity antibodies through interaction with the inducible... Read more

Drug Discovery

view channel

Experimental Small-Molecule Anticancer Drug Blocks RAS-binding Domains

The experimental small-molecule anticancer drug rigosertib was shown to block tumor growth by acting as an RAS-mimetic and interacting with the RAS binding domains of RAF kinases, resulting in their inability to bind to RAS, which inhibited the RAS-RAF-MEK pathway. Oncogenic activation of RAS genes due to point mutations... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Business

view channel

European Biotech Agreement to Promote Antigen-Drug Conjugation Technology

Two European biotech companies have joined forces to exploit and commercialize an innovative, site-specific ADC (antigen-drug conjugate) conjugation technology. ProBioGen (Berlin, Germany), a company specializing in the development and manufacture of complex glycoproteins and Eucodis Bioscience (Vienna, Austria), a... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.