Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

New Device Retrieves Circulating Tumor Cells Without Biochemical Labeling

By BiotechDaily International staff writers
Posted on 18 Jun 2013
Image: The ClearCell FX System for retrieval of circulating tumor cells. (Photo courtesy of Clearbridge BioMedics).
Image: The ClearCell FX System for retrieval of circulating tumor cells. (Photo courtesy of Clearbridge BioMedics).
A new device has been developed for improved cancer diagnosis and monitoring, without biochemical markers, that uses a noninvasive “liquid biopsy” approach for cancer screening, diagnosis, staging, personalized medication, and treatment monitoring.

Clearbridge BioMedics (Singapore) introduces its “ClearCell FX System,” a new generation cancer diagnostic and monitoring device that rapidly detects and isolates intact circulating tumor cells (CTCs) from small quantities of patient blood samples. The ClearCell FX System technology separates and isolates cells by using novel inertia focusing spiral microfluidics in the single-use “CTChip FR.” This enables the continuous label-free separation—without biochemical labels—of CTCs from blood cells. The larger and denser CTCs are separated from other blood cells within the spiral biochip due to biomechanical differences and are then focused into an enriched cell “stream.” These cell streams are channeled and collected into an enriched sample, which can be used for pathology diagnostic tests such as mutation testing for targeted therapies. The isolated CTCs can be stained for identification and enumeration, or retrieved for further molecular analysis.

“This has been a collaborative merging of our extensive experience in diagnostic device development and Clearbridge BioMedics’ expertise in cancer research and diagnostics—and it’s led to breakthrough technology that will have a huge impact on a lot of people’s lives,” said John Pritchard, head of diagnostics at Cambridge Consultants of Altran; “Our systems engineering approach, coupled with our skills in fluidics, software, and compliance, has enabled us to work quickly and efficiently with Clearbridge BioMedics—even though we are thousands of miles apart.” Clearbridge BioMedics also collaborated with the National University of Singapore and the Singapore-MIT Alliance for Research and Technology Center.

The new system, designed for both research and diagnostics applications, will be undergoing regulatory approval in the US and Europe. “Once approved, it will be one of the world’s first label-free CTC enrichment systems for diagnostic use. Clearbridge BioMedics believes this system will be an ideal companion diagnostic system that complements various cancer therapies,” said Johnson Chen, cofounder and managing director of Clearbridge BioMedics.

Related Links:

Clearbridge BioMedics
Cambridge Consultants



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: Differences in the structure of a small lung artery (top row) and heart cross section (lower row) of rodents without disease (far left column); with pulmonary hypertension (middle) and a diseased rodent treated with the HDL peptide (right). Note the much narrowed lung artery, and thick walls and larger chamber of the heart in the diseased animal and improvements with 4F peptide treatment (Photo courtesy of UCLA - University of California, Los Angeles).

Apolipoprotein A-1 Mimetic Peptide Reverses Pulmonary Hypertension in Rodent Models

A small peptide that mimics the activity of apolipoprotein A-1 (apo A-1), the main protein component of the high density lipoproteins (HDL), counteracted the effects of oxidized lipids and alleviated symptoms... Read more

Drug Discovery

view channel
Image: The five stages of biofilm development: (1) Initial attachment, (2) Irreversible attachment, (3) Maturation I, (4) Maturation II, and (5) Dispersion. Each stage of development in the diagram is paired with a photomicrograph of a developing P. aeruginosa biofilm. All photomicrographs are shown to same scale (Photo courtesy of Wikimedia Commons).

Ionic Liquids Disperse Bacterial Biofilms and Increase Antibiotic Susceptibility

The ionic liquid choline-geranate was shown to effectively eliminate the protective biofilm generated by bacteria such as Salmonella enterica and Pseudomonas aeruginosa and to significantly increase the... Read more

Therapeutics

view channel
Image: Hair follicle (blue) being attacked by T cells (green) (Photo courtesy of Christiano Lab/Columbia University Medical Center).

Hair Restoration Method Clones Patients’ Cells to Grow New Hair Follicles

Researchers have developed of a new hair restoration approach that uses a patient’s cells to grow new hair follicles. In addition, the [US] Food and Drugs Administration (FDA) recently approved a new drug... Read more

Lab Technologies

view channel

Important Immune Cell Regulators’ Response Identified

A new strategy could help accelerate laboratory research and the development of potential therapeutics, including vaccines. The technology may also be used to identify the genes that underlie tumor cell development. There are approximately 40,000 genes in each of the body’s cells, but functions for only approximately... Read more

Business

view channel

Partnership Established to Decode Bowel Disease

23andMe (Mountain View, CA,USA), a personal genetics company, is collaborating with Pfizer, Inc. (New York, NY, USA), in which the companies will seek to enroll 10,000 people with inflammatory bowel disease (IBD) in a research project designed to explore the genetic factors associated with the onset, progression, severity,... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.