Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

Data Mining HeData Mining Helps Detect Adverse Drug Reactions

By BiotechDaily International staff writers
Posted on 18 Jun 2013
A new study suggests that information held in electronic medical records (EMRs) can validate previously reported adverse drug reactions (ADRs) and report new ones.

Researchers at the New Jersey Institute of Technology (NJIT; Newark, USA) examined 12 years of EMR data from Vanderbilt University Medical Center (VUMC; Nashville, TN, USA; www.mc.vanderbilt.edu) and reviewed retrospective medication orders and inpatient laboratory results documented in the EMR to identify ADRs. The researchers then assessed the relative merits of six pharmacovigilance measures used in spontaneous reporting systems: proportional reporting ratio (PRR), reporting OR (ROR), Yule's Q (YULE), the CHI-squared test, Bayesian confidence propagation neural networks (BCPNN), and a gamma Poisson shrinker (GPS).

The researchers then systematically evaluated the six methods on two independently constructed reference standard datasets of drug-event pairs. The first was the Yoon et al dataset, containing 470 drug-event pairs (10 drugs and 47 laboratory abnormalities). The second dataset was created using the VUMC EMRs, containing 378 drug-event pairs (9 drugs and 42 laboratory abnormalities). After evaluation, CHI, ROR, PRR, and YULE all had the same F score (62%). When the reference standard of Yoon et al was used, ROR had the best F score of 68%, with 77% precision and 61% recall. The study was published in the May 2013 issue of the Journal of American Medical Informatics Association.

“Medication safety requires that each drug be monitored throughout its market life as early detection of adverse drug reactions can lead to alerts that prevent patient harm,” said lead author computer scientist Mei Liu, PhD. “EMRs have created an unprecedented resource for observational studies since they contain not only detailed patient information, but also large amounts of longitudinal clinical data.”

Pharmacovigilance is the pharmacological science relating to the collection, detection, assessment, monitoring, and prevention of ADRs, which are defined as any response to a drug, which is noxious and unintended, including lack of efficacy, which occurs at doses normally used for the prophylaxis, diagnosis, or therapy of disease, or for the modification of physiological function. ADRs are one of the major causes for failure in drug development, and severe ADRs that go undetected until the postmarketing phase of a drug often lead to patient morbidity, as exemplified by numerous drug withdrawals.

Related Links:

New Jersey Institute of Technology



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: A scheme for the generation of induced pluripotent stem cells (IPSC). (1) Isolate and culture donor cells. (2) Transfect stem cell-associated genes into the cells by viral vectors. Red cells indicate the cells expressing the exogenous genes. (3)  Harvest and culture the cells using mitotically inactivated feeder cells. (4) A small subset of the transfected cells forms iPSC cell colonies (Photo courtesy of Wikimedia Commons).

Innovative Technique Produces More Reliable Pluripotent Stem Cells

A recent paper described a more reliable way to induce the formation of pluripotent stem cells (iPSCs) from adult cells in a mouse model. Reliable high-quality iPSCs are needed for the development of... Read more

Drug Discovery

view channel
Image: S-649266 has more robust antibacterial activity than established antibiotics against multidrug-resistant bacteria (Photo courtesy of Shionogi).

Novel Antibiotic Shows Potential for Broad Range of Infections

The emergence of bacterial resistance to known antibacterial agents is becoming a major challenge in treating the infection caused by multi drug resistant (MDR) bacteria. In order to treat bacterial... Read more

Business

view channel

Collaboration of Mayo Clinic and IBM Cognitive Computer Devised to Improve Clinical Trial Research

The Mayo Clinic (Rochester, MN, USA) and IBM (Armonk, NY, USA) recently announced plans to pilot Watson, the IBM cognitive computer, to match patients more rapidly with suitable clinical trials. A proof-of-concept phase is currently ongoing, with the intent to introduce it into clinical use in early 2015.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.