Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
PZ HTL SA
GLOBETECH PUBLISHING LLC

System Detects Novel Interaction Partners for Membrane Proteins

By BiotechDaily International staff writers
Posted on 14 Jun 2013
Image: The Dualmembrane Kit for identification and investigation of membrane protein interaction partners (Photo courtesy of Dualsystems Biotech AG).
Image: The Dualmembrane Kit for identification and investigation of membrane protein interaction partners (Photo courtesy of Dualsystems Biotech AG).
A system detects interactions involving integral membrane proteins or membrane-associated proteins, facilitating the identification of novel interaction partners and the investigation of interaction domains.

Dualsystems Biotech AG (Schlieren, Switzerland) introduces its “DUALmembrane System” to detect pairwise protein interactions, identify novel protein interactions by cDNA library screening, investigate ternary complexes, and map interaction domains. The system is available in both convenient kit form and as a custom screening service. The DUALmembrane System reliably detects interactions between integral membrane proteins and receptor subunits and coreceptors as well as membrane-associated proteins and soluble proteins. The system is based on properties of ubiquitin, the small protein modifier conserved in eukaryotes that plays a primary role in protein degradation.

The DUALmembrane Kit screens full-length integral membrane proteins for interactions in vivo under the physiological conditions at the membrane, with novel interactions identified through screening of cDNA libraries. The range of available cDNA libraries has recently been significantly broadened by DUALsystems for screening of human tissues, animal tissues, plant cells, and microorganisms. The kit also enables easy subcloning of full-length cDNA inserts using Sfi I technology.

With the DUALmembrane Custom Screening Service, researchers can also save time and money by leveraging Dualsystems Biotech’s extensive experience and expertise in identifying novel interaction partners for proteins of interest. Custom screening is particularly useful for detecting weak or transient interactions.

Related Links:

Dualsystems Biotech
For Membrane Proteins



comments powered by Disqus

Channels

Genomics/Proteomics

view channel

New Program Encourages Wide Distribution of Genomic Data

A new data sharing program allows genomics researchers and practitioners to analyze, visualize, and share raw sequence data for individual patients or across populations straight from a local browser. The sequencing revolution is providing the raw data required to identify the genetic variants underlying rare diseases... Read more

Drug Discovery

view channel
Image: The nano-cocoon drug delivery system is biocompatible, specifically targets cancer cells, can carry a large drug load, and releases the drugs very quickly once inside the cancer cell. Ligands on the surface of the \"cocoon\" trick cancer cells into consuming it. Enzymes (the “worms\" in this image) inside the cocoon are unleashed once inside the cell, destroying the cocoon and releasing anticancer drugs into the cell (Photo courtesy of Dr. Zhen Gu, North Carolina State University).

Novel Anticancer Drug Delivery System Utilizes DNA-Based Nanocapsules

A novel DNA-based drug delivery system minimizes damage to normal tissues by utilizing the acidic microenvironment inside cancer cells to trigger the directed release of the anticancer drug doxorubicin (DOX).... Read more

Business

view channel

Interest in Commercial Applications for Proteomics Continues to Grow

Increasing interest in the field of proteomics has led to a series of agreements between private proteomic companies and academic institutions as well as deals between pharmaceutical companies and novel proteomics innovator biotech companies. Proteomics is the study of the structure and function of proteins.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.