Features | Partner Sites | Information | LinkXpress
Sign In
BioConferenceLive
JIB
GLOBETECH PUBLISHING

System Detects Novel Interaction Partners for Membrane Proteins

By BiotechDaily International staff writers
Posted on 14 Jun 2013
Image: The Dualmembrane Kit for identification and investigation of membrane protein interaction partners (Photo courtesy of Dualsystems Biotech AG).
Image: The Dualmembrane Kit for identification and investigation of membrane protein interaction partners (Photo courtesy of Dualsystems Biotech AG).
A system detects interactions involving integral membrane proteins or membrane-associated proteins, facilitating the identification of novel interaction partners and the investigation of interaction domains.

Dualsystems Biotech AG (Schlieren, Switzerland) introduces its “DUALmembrane System” to detect pairwise protein interactions, identify novel protein interactions by cDNA library screening, investigate ternary complexes, and map interaction domains. The system is available in both convenient kit form and as a custom screening service. The DUALmembrane System reliably detects interactions between integral membrane proteins and receptor subunits and coreceptors as well as membrane-associated proteins and soluble proteins. The system is based on properties of ubiquitin, the small protein modifier conserved in eukaryotes that plays a primary role in protein degradation.

The DUALmembrane Kit screens full-length integral membrane proteins for interactions in vivo under the physiological conditions at the membrane, with novel interactions identified through screening of cDNA libraries. The range of available cDNA libraries has recently been significantly broadened by DUALsystems for screening of human tissues, animal tissues, plant cells, and microorganisms. The kit also enables easy subcloning of full-length cDNA inserts using Sfi I technology.

With the DUALmembrane Custom Screening Service, researchers can also save time and money by leveraging Dualsystems Biotech’s extensive experience and expertise in identifying novel interaction partners for proteins of interest. Custom screening is particularly useful for detecting weak or transient interactions.

Related Links:

Dualsystems Biotech
For Membrane Proteins



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: Blocking the activity of HSP101 may imprison the malaria parasite inside its protective vacuole within the red blood cell. In the electron micrograph, the malaria parasites appear in blue and uninfected red blood cells are shown in red (Photo courtesy of the [US] National Institute of Allergy and Infectious Diseases).

Heat Shock Protein Plays Critical Role in Malaria Parasite Protein Trafficking

A pair of recent papers described the molecular operators that enable the malaria parasite Plasmodium falciparum to export a large variety of proteins across the parasitophorous vacuolar membrane (PVM)... Read more

Drug Discovery

view channel
Image: Molecular rendering of the crystal structure of parkin (Photo courtesy of Wikimedia Commons).

Cinnamon Feeding Blocks Development of Parkinson's Disease in Mouse Model

A team of neurological researchers has identified a molecular mechanism by which cinnamon acts to protect neurons from damage caused by Parkinson's disease (PD) in a mouse model of the syndrome.... Read more

Therapeutics

view channel
Image: This type of electronic pacemaker could become obsolete if induction of biological pacemaker cells by gene therapy proves successful (Photo courtesy of Wikimedia Commons).

Gene Therapy Induces Functional Pacemaker Cells in Pig Heart Failure Model

Cardiovascular disease researchers working with a porcine heart failure model have demonstrated the practicality of using gene therapy to replace implanted electronic pacemakers to regulate heartbeat.... Read more

Business

view channel

Cancer Immunotherapy Sector Predicted to Surge to USD 9 Billion Across Major Pharma Through 2022

The immunotherapy market will experience substantial growth through 2022, increasing from USD 1.1 billion in 2012 to nearly USD 9 billion in 2022 (corresponding to 23.8% annual growth) in the United Kingdom, United States, France, Germany, Italy, Spain, and Japan, according to recent market research. This notable growth... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.