Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING
JIB

Restorative Gel Could Help Reverse Paralysis

By BiotechDaily International staff writers
Posted on 28 May 2013
A biodegradable implant that delivers a therapeutic gel could help restore healthy nerve function in degenerative disorders such as Parkinson's disease.

Researchers at Tel Aviv University (Israel) developed the implant, which is a soft, biodegradable tube that serves as a physical bridge to help the nerve ends connect. Lining the inside of the biodegradable tube is a guiding regeneration gel (GRG), a transparent, highly viscous, malleable, and adaptable gel that increases nerve growth and healing, helping the severed nerve ends to rejoin. But the GRG not only aids reconnection and cell preservation, it can also support their survival while being used for therapy and transplantation.

The key to the regeneration process lies in the composition of the gel, with three main components: superoxide dismutase (SOD) antioxidants, which exhibit high anti-inflammatory activities; synthetic laminin-derived peptides, which act as a railway or track for the nerve fibers to grow along; and hyaluronic acid, commonly found in the human fetus, which serves as a buffer against drying, a major danger for most implants. These components allow the nerve to heal the way a fetus does in the womb - quickly and smoothly.

Research to-date has shown that GRG stimulates cell growth, neuronal sprouting, and extracellular matrix (ECM) formation, supporting cells in vitro and in vivo upon implantation. It also supports three dimensional (3D) growth and differentiation of various cell types (embryonic, adult stem cells, and preneuronal cells). The implications for therapeutic applications include peripheral nerves reconstruction, cell therapy, corneal preservation, wound healing, and as a postirradiation tissue cavity filler.

“The implant has already been tested in animal models, and the gel by itself can be used as a stand-alone product, acting as an aid to cell therapy,” said GRG codeveloper Shimon Rochkind, MD. “When grown in the gel, cells show excellent development, as well as intensive fiber growth. This could have implications for the treatment of diseases such as Parkinson's.”

Related Links:

Tel Aviv University



comments powered by Disqus

Channels

Genomics/Proteomics

view channel

Researchers Discover New Data on Protein Kinase A

By employing X-rays and neutron beams, a team of researchers have gleaned new information about protein kinase A (PKA), an omnipresent master control protein that helps regulate basic cellular functions such as energy consumption and interactions with neurotransmitters, hormones, and drugs. The scientists who conducted... Read more

Drug Discovery

view channel

Molecule in Green Tea Used as Carrier for Anticancer Proteins

A molecule that is a key ingredient in green tea can be employed as a carrier for anticancer proteins, forming a stable and effective therapeutic nanocomplex. This new discovery could help to construct better drug-delivery systems. Some cancer treatments depend on medication comprising the therapeutic drug and a carrier... Read more

Lab Technologies

view channel
Image: The UC Santa Cruz Ebola Genome Portal contains links to the newly created Ebola browser and to scientific literature on the deadly virus (Photo courtesy of UCSC).

Ebola Genome Browser Now Online to Help Scientists’ Respond to Crisis

A US genomics institute has just released a new Ebola genome browser to help international researchers develop a vaccine and antiserum to help stop the spread of the Ebolavirus. The investigators led... Read more

Business

view channel

Interest in Commercial Applications for Proteomics Continues to Grow

Increasing interest in the field of proteomics has led to a series of agreements between private proteomic companies and academic institutions as well as deals between pharmaceutical companies and novel proteomics innovator biotech companies. Proteomics is the study of the structure and function of proteins.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.