Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
PZ HTL SA
GLOBETECH PUBLISHING LLC

Untethered Microgrippers Sample Biologic Tissue

By BiotechDaily International staff writers
Posted on 13 May 2013
Image: A single μ-gripper next to a catheter (Photo courtesy of Johns Hopkins University).
Image: A single μ-gripper next to a catheter (Photo courtesy of Johns Hopkins University).
A new study describes thermally activated microgrippers that can reach narrow conduits in the body and be used to excise tissue for diagnostic analyses and biopsies.

Researchers at Johns Hopkins University (JHU; Baltimore, MD, USA) designed the submillimeter endoscopic microgrippers (μ-grippers) to resemble biological appendages, such as hands, with rigid phalanges and flexible joints. The residual stress powered actuators allow them to close and grasp without the need for tethers, while the rigid phalanges of the μ-grippers are composed of nickel, and hence, respond to an applied magnetic field. A thermo-sensitive polymer trigger layer on the joints keeps the μ-grippers flat at 4 °C, but softens at 37 °C, causing the μ-grippers to close.

The μ-grippers are small enough that hundreds can be deployed at a time and actuated en masse, and could therefore form the basis for a more statistically efficient means to screen large surface area organs such as the colon. To test the feasibility of biologic tissue sampling with μ-grippers, the researchers used a swine colon in ex vivo studies. They uniformly spread hundreds of μ-grippers by rotating the endoscope during the deployment. The arms of each millimeter-long μ-gripper is composed of chromium and gold actuators that naturally want to bend inwards, but are held back by the thin layer of polymer coating.

To simulate the normal human temperature, the colon was submerged in a water bath kept at 37 °C, whereupon the coating dissolved and the talons snatched up cells at close proximity; the researchers then visually verified the closure of the μ-grippers using endoscopic imaging. After closure, the vast majority of μ-grippers were retrieved using a magnetic catheter inserted through the endoscope. The researchers found that the μ-grippers identified the lesion 45% of the time; when the swarm was boosted up to 1,500 μ-grippers, the efficiency rose to 95%. The study was published in the April 2013 issue of Gastroenterology.

“Our results suggest a new paradigm in medicine whereby large numbers of small, tether-free microsurgical tools could complement individual, large, tethered biopsying devices,” concluded lead author Evin Gultepe, PhD, and colleagues of the department of chemical and biomolecular engineering. “The tissue retrieved by the μ-grippers is of sufficient quality and quantity to allow DNA and RNA extraction, as well as polymerase chain reaction (PCR) amplification in an effort to look for previously identified disease-diagnostic markers.”

Related Links:

Johns Hopkins University



RANDOX LABORATORIES
SLAS - Society for Laboratory Automation and Screening
BIOSIGMA S.R.L.
comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: A 3-dimensional picture reveals how the antibodies in the experimental drug Zmapp bind to Ebola virus (Photo courtesy of the Scripps Research Institute).

Electron Microscope Imaging Shows How Experimental Anti-Ebola Drug Works

Electron microscope imaging has revealed how the experimental drug ZMapp binds to the Ebolavirus and provides insights into how the drug prevents growth of the pathogen. ZMapp, which was developed by... Read more

Drug Discovery

view channel

Omega 3 Found to Improve Behavior in Children with ADHD

Supplements of the fatty acids omega 3 and 6 can help children and adolescents who have a specific kind of have attention deficit hyperactivity disorder (ADHD). Moreover, these findings indicate that a customized cognitive training program can improve problem behavior in children with ADHD. Statistics show that 3%–6%... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Lab Technologies

view channel

e-Incubator Technology Provides Real-Time Imaging of Bioengineered Tissues in a Controlled Unit

A new e-incubator, an innovative miniature incubator that is compatible with magnetic resonance imaging (MRI), enables scientists to grow tissue-engineered constructs under a controlled setting and to study their growth and development in real time without risk of contamination or damage. Offering the potential to test... Read more

Business

view channel

Two Industry Partnerships Initiated to Fuel Neuroscience Research

Faster, more complex neural research is now attainable by combining technology from two research companies. Blackrock Microsystems, LLC (Salt Lake City, UT, USA), a developer of neuroscience research equipment, announced partnerships with two neuroscience research firms—PhenoSys, GmbH (Berlin, Germany) and NAN Instruments, Ltd.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.