Features | Partner Sites | Information | LinkXpress
Sign In
PZ HTL SA
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

Brain Imaging Studies Reveal Neurobiology of Eating Disorders

By BiotechDaily International staff writers
Posted on 30 Apr 2013
Current treatments for bulimia nervosa and anorexia are frequently inadequate and ineffective. Patients have a tendency to relapse, become chronically ill, and have a higher risk of dying.

“A major reason contributing to the difficulty in developing new treatments for these disorders is our limited understanding of how brain function may contribute to eating disorder symptoms,” said Walter H. Kaye, MD, professor of psychiatry and director of the Eating Disorder Treatment and Research Program at the University of California (UC), San Diego School of Medicine (USA).

Recently, Dr. Kaye and colleagues reported the situation is changing. Cutting-edge brain imaging technologies, specifically functional magnetic resonance imaging (fMRI), supported by grants from the National Institute of Mental Health (Bethesda, MD, USA), are beginning to be used to study and improve eating disorder treatments. With funding from the Global Foundation for Eating Disorders (GFED; New York, NY, USA), a group that promotes eating disorder (ED) research and improved treatments, the UC San Diego Eating Disorders Center for Treatment and Research has launched a new initiative to create more effective ED therapies based upon brain imaging studies.

“Brain imaging research has allowed for a shift from simply describing a symptom to understanding the cause of a symptom,” said Dr. Kaye. “In the case of anorexia nervosa, imaging studies have helped us understand why people avoid eating and food and develop treatments that address the cause of the problem rather than secondary behaviors or symptoms. This is an important shift in the world of psychiatry similar to what revolutionized medical care decades ago. Today, if you show up at the doctor’s office with a bad cough, he or she might run diagnostics to determine whether the cough was bacterial or viral in order to administer the appropriate treatment. Similarly, the more we understand the specific causes of eating disorders, the more effective, and targeted our treatments can become.”

The UC San Diego program, under the directorship of Dr. Kaye, Kerri Boutelle, PhD, associate professor of pediatrics and psychiatry, Leslie Karwoski Anderson, PhD, clinical assistant professor of psychiatry and GFED scholars Stephanie Knatz and June Liang, is developing an imaging-based treatment strategy exclusively to handle the neurobiology of anorexia nervosa, in which patients obsess about being or becoming overweight. To prevent weight gain or lose weight, people with anorexia nervosa typical may starve themselves or exercise excessively.

Dr. Kaye reported that one neurobiologic target of anorexia and other eating disorders is anxiety. Most people get short-tempered when they do not eat and experience eating as both a reward and pleasant experience. Contrarily, anorexic individuals frequently feel severe anxiety when eating food, or even just anticipating eating, which results in severely reducing their food intake as a means of reducing their feelings of anxiety. “Recent imaging research has uncovered specific alterations in the brain associated with this link between food and anxiety in anorexic individuals,” said Dr. Kaye. “This finding is important because it helps explain the of cause food restriction, the most critical and dangerous behavior in anorexia.”

The UC San Diego researchers have used the new data to create new treatment strategies, including psychoeducation, i.e., teaching patients why symptoms occur and how to more effectively cope. “Many patients have described finally feeling a wave of relief after learning that the anxiety they experience is not their fault, but partly due to how their brain is responding to food,” stated Dr. Kaye. “Understanding why their eating disorder is driving them to restrict allows them to better target their anxiety around meals. Strategies such as developing routines before meals have shown promise in reducing the anticipatory anxiety leading up to meals and food restriction.”

Dr. Kaye noted that the brain-based therapy also benefits families of patients with eating disorders. “Through a better understanding of their family member’s eating disorder and its causes, family members have found comfort and hope with a ‘road map’ guiding them through the recovery.”

Related Links:
University of California, San Diego School of Medicine


Channels

Genomics/Proteomics

view channel
Image: Biopsy of small bowel showing celiac disease manifested by blunting of villi, crypt hyperplasia, and lymphocyte infiltration of crypts (Photo courtesy of Wikimedia Commons).

Reduced Elafin Levels Associated with Celiac Disease Bowel Inflammation

Levels of the enzyme elafin, an endogenous serine protease inhibitor, were lower in the small intestinal epithelium of patients with active celiac disease (CD) as compared to similar tissue from control patients.... Read more

Drug Discovery

view channel

Retinoic Acid Prevents Precancerous Breast Cells from Progressing to Full-Blown Cancer

Retinoic acid, a derivative of vitamin A, was found to prevent pre-cancerous breast cells from progressing to full-blown cancer but did not have any effect on breast tumor cells. Investigators at Thomas Jefferson University (Philadelphia, PA, USA) worked with a novel breast cancer model that had been developed by treating... Read more

Biochemistry

view channel

Mitochondrial Cause of Aging Can Be Reversed

Researchers have found a cause of aging in lab animals that can be reversed, possibly providing an avenue for new treatments for age-related diseases including type 2 diabetes, cancer, muscle wasting, and inflammatory diseases. The researchers plan to begin human trials late 2014. The study, which was published December... Read more

Therapeutics

view channel

Cytokine Identified That Causes Mucositis in Cancer Therapy Patients

The action of the cytokine interleukin 1-beta (IL-1beta) has been found to underlie the onset of mucositis, a common, severe side effect of chemotherapy and irradiation of cancer patients. Mucositis occurs as a result of cell death in reaction to chemo- or radiotherapy. The mucosal lining of the mouth becomes thin, may... Read more

Business

view channel

Analytical Sciences Trade Fair Declared a Rousing Success

Organizers of this year's 24th "analytica" biosciences trade fair have reported significant increases in both the number of visitors and exhibitors compared to the 2012 event. The analytica trade fair for laboratory technology, analysis, and biotechnology has been held at the Munich (Germany) Trade Fair Center every... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.