Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA

Stem Cell Development Could Lead to New Nanoscale Bone Repair Technology

By BiotechDaily International staff writers
Posted on 27 Feb 2013
Image: Stem cell breakthrough could lead to new bone repair therapies (Photo courtesy of the University of Southampton).
Image: Stem cell breakthrough could lead to new bone repair therapies (Photo courtesy of the University of Southampton).
British scientists have created a new application to help generate bone cells that could lead to groundbreaking bone repair therapies for individuals with bone fractures or those who need hip replacement surgery due to osteoporosis and osteoarthritis.

The research, performed by Dr. Emmajayne Kingham, from the University of Southampton (UK), working with colleagues the University of Glasgow (Scotland, UK), and published online January 30, 2013, in the journal Small, cultured human embryonic stem cells on to the surface of plastic materials and evaluated their capability to change.

Scientists were able to use the nanotopographic patterns on the biomedical plastic to manipulate human embryonic stem cells towards bone cells. This was accomplished without any chemical enhancement. The compounds, including the biomedical implantable substance polycarbonate plastic, provide an available and less expensive way of culturing human embryonic stem cells and presents new avenues for future medical research in this field.

Prof. Richard Oreffo, who led the University of Southampton team, explained, “To generate bone cells for regenerative medicine and further medical research remains a significant challenge. However, we have found that by harnessing surface technologies that allow the generation and ultimately scale up of human embryonic stem cells to skeletal cells, we can aid the tissue engineering process. This is very exciting. Our research may offer a whole new approach to skeletal regenerative medicine. The use of nanotopographical patterns could enable new cell culture designs, new device designs, and could herald the development of new bone repair therapies as well as further human stem cell research.”

This latest discovery expands on the close collaborative research earlier undertaken by the University of Southampton and the University of Glasgow. In 2011, the scientists effectively used plastic with embossed nanopatterns to cultivate and spread adult stem cells while maintaining their stem cell properties, a process that is less expensive and simpler to produce than earlier ways of manufacturing.

Dr. Nikolaj Gadegaard, Institute of Molecular, Cell and Systems Biology at the University of Glasgow, remarked, “Our previous collaborative research showed exciting new ways to control mesenchymal stem cell--stem cells from the bone marrow of adults—growth and differentiation on nanoscale patterns. This new Southampton-led discovery shows a totally different stem cell source, embryonic, also respond in a similar manner and this really starts to open this new field of discovery up. With more research impetus, it gives us the hope that we can go on to target a wider variety of degenerative conditions than we originally aspired to. This result is of fundamental significance.”

Related Links:
University of Southampton
University of Glasgow



Channels

Genomics/Proteomics

view channel
Image: The photo shows a mouse pancreatic islet as seen by light microscopy. Beta cells can be recognized by the green insulin staining. Glucagon is labeled in red and the nuclei in blue (Photo courtesy of Wikimedia Commons).

Regenerative Potential Is a Trait of Mature Tissues, Not an Innate Feature of Newly Born Cells

Diabetes researchers have found that the ability of insulin-producing beta cells to replicate and respond to elevated glucose concentrations is absent in very young animals and does not appear until after weaning.... Read more

Drug Discovery

view channel
Image: Wafers like the one shown here are used to create “organ-on-a-chip” devices to model human tissue (Photo courtesy of Dr. Anurag Mathur, University of California, Berkeley).

Human Heart-on-a-Chip Cultures May Replace Animal Models for Drug Development and Safety Screening

Human heart cells growing in an easily monitored silicon chip culture system may one day replace animal-based model systems for drug development and safety screening. Drug discovery and development... Read more

Biochemistry

view channel
Image:  Model depiction of a novel cellular mechanism by which regulation of cryptochromes Cry1 and Cry2 enables coordination of a protective transcriptional response to DNA damage caused by genotoxic stress (Photo courtesy of the journal eLife, March 2015, Papp SJ, Huber AL, et al.).

Two Proteins Critical for Circadian Cycles Protect Cells from Mutations

Scientists have discovered that two proteins critical for maintaining healthy day-night cycles also have an unexpected role in DNA repair and protecting cells against genetic mutations that could lead... Read more

Business

view channel

Roche Acquires Signature Diagnostics to Advance Translational Research

Roche (Basel, Switzerland) will advance translational research for next generation sequencing (NGS) diagnostics by leveraging the unique expertise of Signature Diagnostics AG (Potsdam, Germany) in biobanks and development of novel NGS diagnostic assays. Signature Diagnostics is a privately held translational oncology... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.