Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
JIB
BioConferenceLive

Digital Imaging System Offers Superior Multiple-Biomarker Tissue Analysis

By BiotechDaily International staff writers
Posted on 09 Apr 2012
Image: Tissue IA 2.0 – Automated Image Analysis for Brightfield and Fluorescence Digital Pathology (Photo courtesy of Leica Microsystems).
Image: Tissue IA 2.0 – Automated Image Analysis for Brightfield and Fluorescence Digital Pathology (Photo courtesy of Leica Microsystems).
The Tissue IA 2.0 image analysis system provides pathology researchers with superior capability for immunohistochemistry (IHC) biomarker quantification and tissue localization. The system provides a unique combination of flexibility, automation, and ease-of-use that make it an excellent tool for discovery and translational research in pathology.

Developed and released by Leica Microsystems (Leica; Wetzlar, Germany), the research-only system, Tissue IA 2.0 features fluorescence and brightfield analysis capabilities in a single platform as well as precision cell modeling. Advanced dual staining capabilities enable researchers to identify cell cohorts at the molecular level. Use one marker to identify a population of interest and then quantify expression using a second, providing greater understanding of sample slides. Algorithms are easily adjusted and optimized for different markers, tissue, and protocols, giving a flexible platform, also for drug discovery applications.

Tissue IA 2.0 provides expert tools for retrieval of quantitative, reproducible data from tissue-based IHC studies. Powerful color separation and multimarker co-localization functionality provides advanced insight and unbiased measurement of multiple antigen immunostaining in brightfield or fluorescent samples. Sophisticated cell modeling accurately detects and quantifies differential expression of staining in cellular compartments, providing detailed insight into cytoplasmic, membrane, and nuclear biomarker localization.

“Mulitplexing is of growing importance in translational research and tools to help quantify the expression and location of multiple biomarkers concurrently in tissue are a real requirement. TissueIA 2.0 delivers for the user through offering chromogenic and fluorescence quantification and co-localization, cell based histoscoring on multicompartmental IHC staining and the power to include and exclude cell populations based on biomarker expression. In conjunction with our SCN400 F and Ariol platforms, this further expands our Digital Pathology portfolio for the life science and clinical researcher and demonstrates our ongoing commitment to this area,” said Dr. Donal O’Shea, Head of Digital Pathology in Leica Microsystems. With Tissue IA 2.0, Leica's Digital Pathology portfolio provides streamlined end-to-end excellence in capture, management, and analysis of digital pathology images.

With high throughput batch analysis capacity, Tissue IA 2.0 will process whole slides, regions of interest or tissue microarray cores, and automatically integrate analysis results with user’s slides. A built-in upload interface facilitating integration of algorithms from third party software solutions, gives greater flexibility to further expand analysis options. The system includes a web-accessible interface, enabling users to take their analyses wherever they go.

Leica Microsystems will be at the American Association for Cancer Research Annual Meeting 2012, March 31 to April 4, Chicago, IL. Visit booth 4103 to experience this new image analysis solution for Digital Pathology.


Related Links:
Leica Microsystems
Tissue IA 2.0



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: Blocking the activity of HSP101 may imprison the malaria parasite inside its protective vacuole within the red blood cell. In the electron micrograph, the malaria parasites appear in blue and uninfected red blood cells are shown in red (Photo courtesy of the [US] National Institute of Allergy and Infectious Diseases).

Heat Shock Protein Plays Critical Role in Malaria Parasite Protein Trafficking

A pair of recent papers described the molecular operators that enable the malaria parasite Plasmodium falciparum to export a large variety of proteins across the parasitophorous vacuolar membrane (PVM)... Read more

Drug Discovery

view channel
Image: Molecular rendering of the crystal structure of parkin (Photo courtesy of Wikimedia Commons).

Cinnamon Feeding Blocks Development of Parkinson's Disease in Mouse Model

A team of neurological researchers has identified a molecular mechanism by which cinnamon acts to protect neurons from damage caused by Parkinson's disease (PD) in a mouse model of the syndrome.... Read more

Therapeutics

view channel
Image: This type of electronic pacemaker could become obsolete if induction of biological pacemaker cells by gene therapy proves successful (Photo courtesy of Wikimedia Commons).

Gene Therapy Induces Functional Pacemaker Cells in Pig Heart Failure Model

Cardiovascular disease researchers working with a porcine heart failure model have demonstrated the practicality of using gene therapy to replace implanted electronic pacemakers to regulate heartbeat.... Read more

Business

view channel

Cancer Immunotherapy Sector Predicted to Surge to USD 9 Billion Across Major Pharma Through 2022

The immunotherapy market will experience substantial growth through 2022, increasing from USD 1.1 billion in 2012 to nearly USD 9 billion in 2022 (corresponding to 23.8% annual growth) in the United Kingdom, United States, France, Germany, Italy, Spain, and Japan, according to recent market research. This notable growth... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.