Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
BioConferenceLive

Digital Imaging System Offers Superior Multiple-Biomarker Tissue Analysis

By BiotechDaily International staff writers
Posted on 09 Apr 2012
Image: Tissue IA 2.0 – Automated Image Analysis for Brightfield and Fluorescence Digital Pathology (Photo courtesy of Leica Microsystems).
Image: Tissue IA 2.0 – Automated Image Analysis for Brightfield and Fluorescence Digital Pathology (Photo courtesy of Leica Microsystems).
The Tissue IA 2.0 image analysis system provides pathology researchers with superior capability for immunohistochemistry (IHC) biomarker quantification and tissue localization. The system provides a unique combination of flexibility, automation, and ease-of-use that make it an excellent tool for discovery and translational research in pathology.

Developed and released by Leica Microsystems (Leica; Wetzlar, Germany), the research-only system, Tissue IA 2.0 features fluorescence and brightfield analysis capabilities in a single platform as well as precision cell modeling. Advanced dual staining capabilities enable researchers to identify cell cohorts at the molecular level. Use one marker to identify a population of interest and then quantify expression using a second, providing greater understanding of sample slides. Algorithms are easily adjusted and optimized for different markers, tissue, and protocols, giving a flexible platform, also for drug discovery applications.

Tissue IA 2.0 provides expert tools for retrieval of quantitative, reproducible data from tissue-based IHC studies. Powerful color separation and multimarker co-localization functionality provides advanced insight and unbiased measurement of multiple antigen immunostaining in brightfield or fluorescent samples. Sophisticated cell modeling accurately detects and quantifies differential expression of staining in cellular compartments, providing detailed insight into cytoplasmic, membrane, and nuclear biomarker localization.

“Mulitplexing is of growing importance in translational research and tools to help quantify the expression and location of multiple biomarkers concurrently in tissue are a real requirement. TissueIA 2.0 delivers for the user through offering chromogenic and fluorescence quantification and co-localization, cell based histoscoring on multicompartmental IHC staining and the power to include and exclude cell populations based on biomarker expression. In conjunction with our SCN400 F and Ariol platforms, this further expands our Digital Pathology portfolio for the life science and clinical researcher and demonstrates our ongoing commitment to this area,” said Dr. Donal O’Shea, Head of Digital Pathology in Leica Microsystems. With Tissue IA 2.0, Leica's Digital Pathology portfolio provides streamlined end-to-end excellence in capture, management, and analysis of digital pathology images.

With high throughput batch analysis capacity, Tissue IA 2.0 will process whole slides, regions of interest or tissue microarray cores, and automatically integrate analysis results with user’s slides. A built-in upload interface facilitating integration of algorithms from third party software solutions, gives greater flexibility to further expand analysis options. The system includes a web-accessible interface, enabling users to take their analyses wherever they go.

Leica Microsystems will be at the American Association for Cancer Research Annual Meeting 2012, March 31 to April 4, Chicago, IL. Visit booth 4103 to experience this new image analysis solution for Digital Pathology.


Related Links:
Leica Microsystems
Tissue IA 2.0



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: Microcomputed tomography images (top) and histology images (bottom) of the knees of mice fed a very high fat diet containing omega-3 fatty acid supplement (left) or only omega-6 fatty acids (right) after a knee injury. The omega-6 diet showed abnormal bone remodeling and calcified tissue formation in the joint (white arrow). The omega-6 diet also showed significant loss of cartilage (red staining, yellow arrowhead) and increased joint inflammation (Photo courtesy of Duke University).

Dietary Omega-3 Fatty Acids Moderate Severity of Osteoarthritis in a Mouse Model

Researchers working with an osteoarthritis (OA) obese mouse model found that the fat content of the animals' diet contributed more to the development or arrest of OA than did body weight.... Read more

Drug Discovery

view channel
Image: Molecular rendering of the crystal structure of parkin (Photo courtesy of Wikimedia Commons).

Cinnamon Feeding Blocks Development of Parkinson's Disease in Mouse Model

A team of neurological researchers has identified a molecular mechanism by which cinnamon acts to protect neurons from damage caused by Parkinson's disease (PD) in a mouse model of the syndrome.... Read more

Therapeutics

view channel

Vaccine Being Developed for Heart Disease Close to Reality

The world’s first vaccine for heart disease is becoming a possibility with researchers demonstrating significant arterial plaque reduction in concept testing in mice. Klaus Ley, MD, from the La Jolla Institute for Allergy and Immunology (LA Jolla, CA, USA), and a vascular immunology specialist, is leading the vaccine... Read more

Business

view channel

A Surge in IPOs Revitalize Investments for the Global Pharma and Biotech

Anti-infective drugs, oncology, and pharmaceutical contract laboratories attract the most investment up to now. The intensified private equity and venture capital (PEVC) deal activity in the global healthcare industry during the recession years, 2008–2010, witnessed a waning post-2010. However, the decline in deals... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.