Features | Partner Sites | Information | LinkXpress
Sign In
PURITAN MEDICAL
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC

Dietary Omega-3 Fatty Acids Moderate Severity of Osteoarthritis in a Mouse Model

By BiotechDaily International staff writers
Posted on 22 Jul 2014
Image: Microcomputed tomography images (top) and histology images (bottom) of the knees of mice fed a very high fat diet containing omega-3 fatty acid supplement (left) or only omega-6 fatty acids (right) after a knee injury. The omega-6 diet showed abnormal bone remodeling and calcified tissue formation in the joint (white arrow). The omega-6 diet also showed significant loss of cartilage (red staining, yellow arrowhead) and increased joint inflammation (Photo courtesy of Duke University).
Image: Microcomputed tomography images (top) and histology images (bottom) of the knees of mice fed a very high fat diet containing omega-3 fatty acid supplement (left) or only omega-6 fatty acids (right) after a knee injury. The omega-6 diet showed abnormal bone remodeling and calcified tissue formation in the joint (white arrow). The omega-6 diet also showed significant loss of cartilage (red staining, yellow arrowhead) and increased joint inflammation (Photo courtesy of Duke University).
Researchers working with an osteoarthritis (OA) obese mouse model found that the fat content of the animals' diet contributed more to the development or arrest of OA than did body weight.

Investigators at Duke University (Durham, NC, USA) fed different groups of mice either a diet rich in saturated fatty acids (SFAs), omega-6 polyunsaturated FAs (PUFAs), or omega-6 PUFAs supplemented with omega-3 PUFAs. OA was induced by destabilizing the medial meniscus. Wound healing was evaluated using an ear punch. OA, synovitis, and wound healing were determined histologically, while bone changes were measured using microCT (computerized tomography).

Results published in the July 10, 2014, online edition of the journal Annals of the Rheumatic Diseases revealed that OA was significantly associated with dietary fatty acid content and serum adipokine levels, but not with body weight. Furthermore, spontaneous activity of the mice was independent of OA development. Small amounts of omega-3 PUFAs (8% by kilocalorie) in a high-fat diet were sufficient to mitigate injury-induced OA. Omega-3 PUFAs significantly enhanced wound repair, while SFAs or omega-6 PUFAs independently increased OA severity, ossification, and scar tissue formation.

“Our results suggest that dietary factors play a more significant role than mechanical factors in the link between obesity and osteoarthritis,” said senior author Dr. Farshid Guilak, professor of orthopedic surgery at Duke University. “While omega-3 fatty acids are not reversing the injury, they appear to slow the progression of arthritis in this group of mice. In fact, omega-3 fatty acids eliminated the detrimental effects of obesity in obese mice. A great next step would be to do a clinical study to look at effect of omega-3 fatty acids post-injury.”


Related Links:
Duke University



Channels

Drug Discovery

view channel
Image: A new micelle delivery system for the protective polyphenols resveratrol and quercetin (mRQ) may have value in cancer chemotherapy (Photo courtesy of Oregon State University).

Micelles Containing Resveratrol and Quercetin Reverse Doxorubicin Cardiotoxicity

Cancer researchers blocked the toxic effects of the cancer drug doxorubicin (DOX) by administering it together with the plant antioxidants resveratrol and quercetin. Although in use for more than 40... Read more

Lab Technologies

view channel
Image: The Leica DM2500 LED Microscope for clinical laboratories and research applications (Photo courtesy of Leica Microsystems).

New LED Microscope Completes Line of Clinical and Research Tools

A popular microscope used for both clinical and research applications is now available with LED illumination. The Leica (Wetzlar, Germany) DM2500 and DM2500 LED microscopes represent a class of tools... Read more

Business

view channel

Teva Buys Allergan Generic Business Unit

Teva Pharmaceutical Industries (Petah Tikva, Israel) has bought the Allergan (Irvine, CA, USA) generic drugs business for USD 40.5 billion in cash and stock, solidifying its position as the world's largest generic drug maker. Under the terms of the agreement, Teva will pay USD 33.75 billion in cash and USD 6.... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.