Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

Polyphenol-Rich Cocoa Extracts Protect Against Alzheimer's Disease

By BiotechDaily International staff writers
Posted on 08 Jul 2014
Image: Dutch process cocoa (left) compared to natural cocoa (right) (Photo courtesy of Wikimedia Commons).
Image: Dutch process cocoa (left) compared to natural cocoa (right) (Photo courtesy of Wikimedia Commons).
A recent paper suggested that flavonol-rich cocoa extracts interfere with the processes that lead to the development of Alzheimer's disease.

Alzheimer's disease (AD) is characterized by pathological aggregates of amyloid peptide-beta (Abeta) and tau protein. Currently available therapies ease AD symptoms but do not slow progression of the disease.

Previous studies have reported that polyphenol-rich diets reduce the risk for developing AD. In the present study, investigators at the Icahn School of Medicine at Mount Sinai (New York, NY, USA) evaluated the AD disease-modifying effects of cocoa, a rich source of flavanols, which are a class of polyphenols.

The investigators tested the effects of three different cocoa extracts (Natural, Dutched, and Lavado), on Abeta42 and Abeta40 oligomerization, using the photo-induced cross-linking of unmodified proteins technique. To assess the effects of cocoa extracts on synaptic function, they measured long term potentiation in mouse brain hippocampal slices exposed to oligomeric Abeta.

Results published in the June 23, 2014, online edition of the Journal of Alzheimer’s Disease revealed that cocoa extracts were effective in preventing the oligomerization of Abeta, with Lavado extract being most effective. Lavado extract, but not Dutched extract, was effective in restoring the long term potentiation response reduced by oligomeric Abeta. The Dutch process lowers acidity, increases solubility, enhances color, and smoothes flavor. Compared to other processes, Dutch process chocolate contains lower amounts of flavonols.

“Our data suggest that Lavado cocoa extract prevents the abnormal formation of Abeta into clumped oligomeric structures, to prevent synaptic insult and eventually cognitive decline,” said senior author Dr. Giulio Maria Pasinetti, professor of neurology at the Icahn School of Medicine at Mount Sinai. “Given that cognitive decline in Alzheimer’s disease is thought to start decades before symptoms appear, we believe our results have broad implications for the prevention of Alzheimer’s disease and dementia.”

“There have been some inconsistencies in medical literature regarding the potential benefit of cocoa polyphenols on cognitive function,” said Dr. Pasinetti. “Our finding of protection against synaptic deficits by Lavado cocoa extract, but not Dutched cocoa extract, strongly suggests that polyphenols are the active component that rescue synaptic transmission, since much of the polyphenol content is lost by the high alkalinity in the Dutching process.”

Related Links:

Icahn School of Medicine at Mount Sinai



comments powered by Disqus

Channels

Drug Discovery

view channel

Ibuprofen May Restore Immune Function in Older Individuals

New research suggests that macrophages from the lungs of old mice respond differently to infections than those of young mice, and ibuprofen given to the mice reversed these changes. New research using lab mice suggests that the solution to more youthful immune function might already be a common over-the-counter pain reliever.... Read more

Therapeutics

view channel
Image: Hair follicle (blue) being attacked by T cells (green) (Photo courtesy of Christiano Lab/Columbia University Medical Center).

Hair Restoration Method Clones Patients’ Cells to Grow New Hair Follicles

Researchers have developed of a new hair restoration approach that uses a patient’s cells to grow new hair follicles. In addition, the [US] Food and Drugs Administration (FDA) recently approved a new drug... Read more

Lab Technologies

view channel
Image: Leica Microsystems launches the inverted research microscope platform Leica DMi8 (Photo courtesy of Leica Microsystems).

New Inverted Microscope Designed to Readily Adapt to Changing Research Demands

A new inverted microscope for biotech and other life science laboratories was designed to readily accommodate modifications and upgrades to allow it to keep current with changing research demands and interests.... Read more

Business

view channel

Collaboration of Mayo Clinic and IBM Cognitive Computer Devised to Improve Clinical Trial Research

The Mayo Clinic (Rochester, MN, USA) and IBM (Armonk, NY, USA) recently announced plans to pilot Watson, the IBM cognitive computer, to match patients more rapidly with suitable clinical trials. A proof-of-concept phase is currently ongoing, with the intent to introduce it into clinical use in early 2015.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.