Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
PZ HTL SA

Verteporfin Blocks Growth of Deadly Eye Melanoma

By BiotechDaily International staff writers
Posted on 08 Jun 2014
Image: An untreated uveal melanoma tumor (left) covers entire eye of a mouse. A tumor treated with verteporfin (right) is much smaller and much of the structure of the mouse\'s eye is visible (Photo courtesy of UCSD - University of California, San Diego).
Image: An untreated uveal melanoma tumor (left) covers entire eye of a mouse. A tumor treated with verteporfin (right) is much smaller and much of the structure of the mouse\'s eye is visible (Photo courtesy of UCSD - University of California, San Diego).
Simultaneous mutations in two G-protein encoding genes that cause the overexpression of a carcinogenic protein have been linked to the development of uveal melanoma, a deadly cancer of the colored areas of the eye.

Uveal melanoma is a rare cancer that is usually treated by surgical removal of the eye. However, uveal melanoma can spread to the liver, in which case patients typically die within two to eight months after diagnosis.

Genome studies have shown that a mutation in either the GNAQ (guanine nucleotide binding protein, q polypeptide) or GNA11 (guanine nucleotide-binding protein subunit alpha-11) genes, which encode the proteins Gq or G11, respectively, are found in about 70% of uveal melanoma tumors.

In the current study, which was published in the May 29, 2014, online edition of the journal Cancer Cell, investigators at the University of California, San Diego (USA) revealed that that these mutations cause the G-proteins to become permanently activated, which results in overexpression of the Yes-associated protein (YAP). Overexpression of YAP protein induces uncontrolled cell growth and inhibits cell death, triggering cancer development. Furthermore, treatment of uveal melanoma tumors with the YAP inhibitor drug verteporfin blocked tumor growth of cells containing Gq/G11 mutations.

“The beauty of our study is its simplicity,” said senior author Dr. Kun-Liang Guan, professor of pharmacology at the University of California, San Diego. “The genetics of this cancer are very simple and our results have clear implications for therapeutic treatments for the disease. We have a cancer that is caused by a very simple genetic mechanism, and we have a drug that works on this mechanism. The clinical applications are very direct.”

Related Links:

University of California, San Diego



comments powered by Disqus

Channels

Drug Discovery

view channel
Image: The nano-cocoon drug delivery system is biocompatible, specifically targets cancer cells, can carry a large drug load, and releases the drugs very quickly once inside the cancer cell. Ligands on the surface of the \"cocoon\" trick cancer cells into consuming it. Enzymes (the “worms\" in this image) inside the cocoon are unleashed once inside the cell, destroying the cocoon and releasing anticancer drugs into the cell (Photo courtesy of Dr. Zhen Gu, North Carolina State University).

Novel Anticancer Drug Delivery System Utilizes DNA-Based Nanocapsules

A novel DNA-based drug delivery system minimizes damage to normal tissues by utilizing the acidic microenvironment inside cancer cells to trigger the directed release of the anticancer drug doxorubicin (DOX).... Read more

Lab Technologies

view channel

Experimental Physicists Find Clues into How Radiotherapy Kills Cancer Cells

A new discovery in experimental physics has implications for a better determination of the process in which radiotherapy destroys cancer cells. Dr. Jason Greenwood from Queen’s University Belfast (Ireland) Center for Plasma Physics collaborated with scientists from Italy and Spain on the work on electrons, and published... Read more

Business

view channel

Interest in Commercial Applications for Proteomics Continues to Grow

Increasing interest in the field of proteomics has led to a series of agreements between private proteomic companies and academic institutions as well as deals between pharmaceutical companies and novel proteomics innovator biotech companies. Proteomics is the study of the structure and function of proteins.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.