Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
PZ HTL SA

Loss of Tumor Suppressor Gene Promotes Breast Cancer Metastasis into the Lungs

By BiotechDaily International staff writers
Posted on 08 Jun 2014
Image: Graphic explaining the consequences of the loss of function of RARRES3 for breast cancer lung metastasis (Photo courtesy of the Institute for Research in Biomedicine).
Image: Graphic explaining the consequences of the loss of function of RARRES3 for breast cancer lung metastasis (Photo courtesy of the Institute for Research in Biomedicine).
Cancer researchers have found that loss of a specific tumor suppressor gene promotes the metastasis of breast cancer cells into the lungs.

Investigators at the Institute for Research in Biomedicine (Barcelona, Spain) characterized the biological activity of RARRES3 (retinoic acid receptor responder protein 3), a recently identified metastasis suppressor gene whose reduced expression in primary breast tumors identifies a subgroup of patients more likely to develop lung metastasis. This work was carried out on samples from mice and in cell lines, and then was validated in 580 samples from human primary breast cancer tumors.

Results published in the May 27, 2014, online edition of the journal EMBO Molecular Medicine revealed that the loss of function of the RARRES3 gene in primary breast tumor cells promoted metastasis to the lung. RARRES3 downregulation engaged metastasis-initiating capabilities by facilitating adhesion of the tumor cells to the lung parenchyma. In addition, impaired tumor cell differentiation due to the loss of RARRES3 phospholipase A1/A2 activity also contributed to lung metastasis.

Looking at the results from the other direction, it was clear that the investigators had shown that RARRES3 blocked adhesion to the lung parenchyma and, second, the phospholipase activity of RARRES3 stimulated differentiation attributes, thus blunting metastasis-initiating functions at the lung required for the breast cancer cells to establish a lesion.

"RARRES3 is suppressed in estrogen receptor-negative (ER-) breast cancer tumors, thus stimulating the later invasion of the cancer cells and conferring them a greater malignant capacity," said senior author Dr. Roger Gomis, head of the growth control and cancer metastasis laboratory at the Institute for Research in Biomedicine. "The transformation of a normal cell into an invasive tumor cell is not just about acquiring capacities but equally important is the loss of certain genes, such as RARRES3."

Related Links:

Institute for Research in Biomedicine



RANDOX LABORATORIES
BIOSIGMA S.R.L.
SLAS - Society for Laboratory Automation and Screening
comments powered by Disqus

Channels

Drug Discovery

view channel

Omega 3 Found to Improve Behavior in Children with ADHD

Supplements of the fatty acids omega 3 and 6 can help children and adolescents who have a specific kind of have attention deficit hyperactivity disorder (ADHD). Moreover, these findings indicate that a customized cognitive training program can improve problem behavior in children with ADHD. Statistics show that 3%–6%... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Lab Technologies

view channel

e-Incubator Technology Provides Real-Time Imaging of Bioengineered Tissues in a Controlled Unit

A new e-incubator, an innovative miniature incubator that is compatible with magnetic resonance imaging (MRI), enables scientists to grow tissue-engineered constructs under a controlled setting and to study their growth and development in real time without risk of contamination or damage. Offering the potential to test... Read more

Business

view channel

Two Industry Partnerships Initiated to Fuel Neuroscience Research

Faster, more complex neural research is now attainable by combining technology from two research companies. Blackrock Microsystems, LLC (Salt Lake City, UT, USA), a developer of neuroscience research equipment, announced partnerships with two neuroscience research firms—PhenoSys, GmbH (Berlin, Germany) and NAN Instruments, Ltd.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.