Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING
JIB

Genomic Studies Reveal Links Between Prostate Cancer and Cardiovascular Disease

By BiotechDaily International staff writers
Posted on 13 May 2014
Image: Micrograph of normal prostatic glands and those with prostate adenocarcinoma (upper right portion of image) (Photo courtesy of Wikimedia Commons).
Image: Micrograph of normal prostatic glands and those with prostate adenocarcinoma (upper right portion of image) (Photo courtesy of Wikimedia Commons).
A large-scale statistical evaluation of genomic studies linked to either prostate cancer (PCA) or cardiovascular disease (CVD) risk identified 17 genetic loci that link prostate cancer to risk of developing CVD.

Investigators at Oslo University (Norway) and their colleagues at the University of California, San Diego (USA) applied a genetic epidemiology method based on conjunction false discovery rate (FDR) that combined summary statistics from different genome-wide association studies (GWAS), and allowed identification of genetic overlap between two phenotypes. FDR is a statistical method used in multiple hypotheses testing to correct for multiple comparisons. In a list of findings, FDR procedures are designed to control the expected proportion of incorrectly rejected null hypotheses.

The investigators evaluated summary statistics from large, multicenter GWA studies of PCA (n = 50,000) and CVD risk factors (n = 200,000). CVD risk factors included triglycerides (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, systolic blood pressure, body mass index, waist-hip ratio, and type II diabetes.

Results published in the April 30, 2014, online edition of the International Journal of Epidemiology revealed that the strongest association between PCA and CVD risk was conditional on LDL and TG. In contrast, the investigators found only weak enrichment conditional on HDL or conditional on the other traits investigated. Conjunction FDR identified altogether 17 loci; 10 loci were associated with PCA and LDL, three loci were associated with PCA and TG and additionally four loci were associated with PCA, LDL, and TG jointly.

"It is fair to say that risk relationships of various sorts have been proposed between prostate cancer and cardiovascular disease, although not comorbidity per se," said contributing author Dr. Ian G. Mills, researcher in the prostate cancer group at the University of Oslo. "There is a lack of consistency across cohorts, however, in size and direction of effects, depending on cardiovascular risk factor considered. The significant risk association with LDL cholesterol and triglycerides versus the other traits at a genetic level was novel and unexpected."

Related Links:

Oslo University
University of California, San Diego



comments powered by Disqus

Channels

Drug Discovery

view channel

Ibuprofen May Restore Immune Function in Older Individuals

New research suggests that macrophages from the lungs of old mice respond differently to infections than those of young mice, and ibuprofen given to the mice reversed these changes. New research using lab mice suggests that the solution to more youthful immune function might already be a common over-the-counter pain reliever.... Read more

Therapeutics

view channel
Image: Hair follicle (blue) being attacked by T cells (green) (Photo courtesy of Christiano Lab/Columbia University Medical Center).

Hair Restoration Method Clones Patients’ Cells to Grow New Hair Follicles

Researchers have developed of a new hair restoration approach that uses a patient’s cells to grow new hair follicles. In addition, the [US] Food and Drugs Administration (FDA) recently approved a new drug... Read more

Lab Technologies

view channel
Image: Leica Microsystems launches the inverted research microscope platform Leica DMi8 (Photo courtesy of Leica Microsystems).

New Inverted Microscope Designed to Readily Adapt to Changing Research Demands

A new inverted microscope for biotech and other life science laboratories was designed to readily accommodate modifications and upgrades to allow it to keep current with changing research demands and interests.... Read more

Business

view channel

Collaboration of Mayo Clinic and IBM Cognitive Computer Devised to Improve Clinical Trial Research

The Mayo Clinic (Rochester, MN, USA) and IBM (Armonk, NY, USA) recently announced plans to pilot Watson, the IBM cognitive computer, to match patients more rapidly with suitable clinical trials. A proof-of-concept phase is currently ongoing, with the intent to introduce it into clinical use in early 2015.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.