Features Partner Sites Information LinkXpress
Sign In
Advertise with Us


12 Nov 2016 - 16 Nov 2016
16 Nov 2016 - 19 Nov 2016

Protein Found to Play Key Role in Long Life

By BiotechDaily International staff writers
Posted on 02 Oct 2013
Print article
Image: The structure of the sirtuin protein Sirt1 (Photo courtesy of Shin-ichiro Imai/Washington University in St. Louis).
Image: The structure of the sirtuin protein Sirt1 (Photo courtesy of Shin-ichiro Imai/Washington University in St. Louis).
The process behind the functioning of a specific protein already believed to play a role in longevity has recently been established to do just that, lengthen lifespan.

Developmental biologist Dr. Shin-ichiro Imai, from Washington University in St. Louis (MO, USA), discovered that instead of delaying the aging process, the protein works in the brain to delay the onset of aging, thus extending youth and adding those energetic years onto one’s life span.

The researchers engineered lab mice that expressed higher than normal levels of Sirt1 in their brain and saw a substantial extension in the animals’ life spans. The scientists specifically found that Sirt1 plays a vital role in protecting against age-related declines in skeletal muscle, physical activity, body temperature, oxygen consumption, and quality of sleep. The start of the disease process in mice trigger to contract cancer was also delayed.

This new finding could help researchers better determine how to extend the life span of other mammals, including humans. The result is published September 3, 2013, in the journal Cell Metabolism.

Related Links:
Washington University in St. Louis

Print article


Drug Discovery

view channel
Image: Positive alpha-synuclein staining of a Lewy body from a patient with Parkinson\'s disease (Photo courtesy of Wikimedia Commons).

Bifunctional Dimer Drugs Prove Effective in Parkinson's Disease Yeast Model

A team of Canadian neurodegenerative disease researchers used a yeast model system to identify novel drug compounds that were able to block the misfolding of alpha- synuclein (AS) protein, which characterizes... Read more


view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more


view channel

Collaborative Agreement to Aid in Setting Guidelines for Evaluating Potential Ebola Therapy

Cooperation between an Israeli biopharmaceutical company and medical branches of the US government is designed to set ground rules for continued evaluation of an experimental therapy for Ebola virus disease. RedHill Biopharma Ltd. (Tel Aviv, Israel), a biopharmaceutical company primarily focused on development and c... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.