Features | Partner Sites | Information | LinkXpress
Sign In
BioConferenceLive
JIB
GLOBETECH PUBLISHING

An Organism's Genetic Background Influences how Mutant Genes Are Expressed

By BiotechDaily International staff writers
Posted on 19 Aug 2013
Image: By focusing on fruit fly wings and a genetic mutation that alters them, Michigan State University researchers demonstrated the influence of wild type genetic background was actually quite common  (Photo courtesy of Michigan State University).
Image: By focusing on fruit fly wings and a genetic mutation that alters them, Michigan State University researchers demonstrated the influence of wild type genetic background was actually quite common (Photo courtesy of Michigan State University).
Expression of a phenotype caused by a mutation in a gene or set of genes is heavily influenced by interactions among the other genes that make up the genome of the organism.

Investigators at Michigan State University (East Lansing, USA) worked with the fruit fly Drosophila melanogaster, an intensively studied model system for human genetic interactions.

They focused on a genetic mutation that alters the shape of fruit fly wings and discovered that about 75% of the time the individual fly's wild type genetic background affected the expression of the mutated gene. This finding was published in the August 1, 2013, online edition of the journal PLOS Genetics.

"It has been known for a while that genetic mutations can modify each other's effects," said senior author Dr. Ian Dworkin, associate professor of zoology at Michigan State University. "And we also know that the subtle differences in an individual's genome—what scientists call wild type genetic background—also affects how mutations are manifested."

Many disorders with a suspected genetic component, such as cancer, asthma, or Parkinson's disease, have been linked to interactions between more than one set of genes. "Is it just the two pairs of genes that are interacting?" asked Dr. Dworkin. "Or is it that the two genes are interacting and then many other genes are modifying that reaction? This will help us understand how much complexity is involved."

Related Links:

Michigan State University




comments powered by Disqus

Channels

Drug Discovery

view channel
Image: Molecular rendering of the crystal structure of parkin (Photo courtesy of Wikimedia Commons).

Cinnamon Feeding Blocks Development of Parkinson's Disease in Mouse Model

A team of neurological researchers has identified a molecular mechanism by which cinnamon acts to protect neurons from damage caused by Parkinson's disease (PD) in a mouse model of the syndrome.... Read more

Therapeutics

view channel
Image: This type of electronic pacemaker could become obsolete if induction of biological pacemaker cells by gene therapy proves successful (Photo courtesy of Wikimedia Commons).

Gene Therapy Induces Functional Pacemaker Cells in Pig Heart Failure Model

Cardiovascular disease researchers working with a porcine heart failure model have demonstrated the practicality of using gene therapy to replace implanted electronic pacemakers to regulate heartbeat.... Read more

Lab Technologies

view channel
Image: A one-year-old baby sits in a brain scanner, called magnetoencephalography (MEG)—a noninvasive approach to measuring brain activity. The baby listens to speech sounds such as “da” and “ta” played over headphones while researchers record her brain responses (Photo courtesy of the Institute for Learning & Brain Sciences at the University of Washington).

Brain Scanner Shows Infants’ Brains Rehearse Speech Sounds Months Before Their First Words

New research in 7- and 11-month-old infants revealed that speech sounds stimulate brain regions that coordinate and plan motor movements for speech. The new study suggests that babies’ brains begin establishing... Read more

Business

view channel

Cancer Immunotherapy Sector Predicted to Surge to USD 9 Billion Across Major Pharma Through 2022

The immunotherapy market will experience substantial growth through 2022, increasing from USD 1.1 billion in 2012 to nearly USD 9 billion in 2022 (corresponding to 23.8% annual growth) in the United Kingdom, United States, France, Germany, Italy, Spain, and Japan, according to recent market research. This notable growth... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.