Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
JIB
GLOBETECH PUBLISHING

An Organism's Genetic Background Influences how Mutant Genes Are Expressed

By BiotechDaily International staff writers
Posted on 19 Aug 2013
Image: By focusing on fruit fly wings and a genetic mutation that alters them, Michigan State University researchers demonstrated the influence of wild type genetic background was actually quite common  (Photo courtesy of Michigan State University).
Image: By focusing on fruit fly wings and a genetic mutation that alters them, Michigan State University researchers demonstrated the influence of wild type genetic background was actually quite common (Photo courtesy of Michigan State University).
Expression of a phenotype caused by a mutation in a gene or set of genes is heavily influenced by interactions among the other genes that make up the genome of the organism.

Investigators at Michigan State University (East Lansing, USA) worked with the fruit fly Drosophila melanogaster, an intensively studied model system for human genetic interactions.

They focused on a genetic mutation that alters the shape of fruit fly wings and discovered that about 75% of the time the individual fly's wild type genetic background affected the expression of the mutated gene. This finding was published in the August 1, 2013, online edition of the journal PLOS Genetics.

"It has been known for a while that genetic mutations can modify each other's effects," said senior author Dr. Ian Dworkin, associate professor of zoology at Michigan State University. "And we also know that the subtle differences in an individual's genome—what scientists call wild type genetic background—also affects how mutations are manifested."

Many disorders with a suspected genetic component, such as cancer, asthma, or Parkinson's disease, have been linked to interactions between more than one set of genes. "Is it just the two pairs of genes that are interacting?" asked Dr. Dworkin. "Or is it that the two genes are interacting and then many other genes are modifying that reaction? This will help us understand how much complexity is involved."

Related Links:

Michigan State University




comments powered by Disqus

Channels

Drug Discovery

view channel
Image: Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells (Photo courtesy of the University of Texas, Austin).

Experimental Drug Kills Cancer Cells by Interfering with Their Ion Transport Mechanism

An experimental anticancer drug induces cells to enter a molecular pathway leading to apoptosis by skewing their ion transport systems to greatly favor the influx of chloride anions. To promote development... Read more

Therapeutics

view channel
Image: Liver cells regenerated in mice treated with a new drug (right) compared with a control group (center) after partial liver removal. Healthy liver cells are shown at left (Photo courtesy of Marshall et al, 2014, the Journal of Experimental Medicine).

New Drug Triggers Liver Regeneration After Surgery

Investigators have revealed that an innovative complement inhibitor decreases complement-mediated liver cell death, and actually stimulates postsurgery liver regrowth in mice. Liver cancer often results... Read more

Lab Technologies

view channel

White-Matter Deficits Found in Codeine-Containing Cough Syrup Users

A magnetic resonance imaging (MRI) study of chronic users of codeine-containing cough syrups (CCS) has found deficits in specific regions of brain white matter and linked these changes with increased impulsivity in codeine-containing cough syrup users. These findings were consistent with findings from earlier research of... Read more

Business

view channel

Partnership Established to Decode Bowel Disease

23andMe (Mountain View, CA,USA), a personal genetics company, is collaborating with Pfizer, Inc. (New York, NY, USA), in which the companies will seek to enroll 10,000 people with inflammatory bowel disease (IBD) in a research project designed to explore the genetic factors associated with the onset, progression, severity,... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.