Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
PZ HTL SA

Immune System Regulator Allows Inflammatory Response While Preventing Autoimmune Attack

By BiotechDaily International staff writers
Posted on 18 Jun 2013
Image: Schematic of balance between tolerance and inflammation mediated by BACH2 (Photo courtesy of the US National Institutes of Health).
Image: Schematic of balance between tolerance and inflammation mediated by BACH2 (Photo courtesy of the US National Institutes of Health).
The BACH2 (BTB and CNC homology 1, basic leucine zipper transcription factor 2) gene was shown recently to encode for a protein that acts as a master immune system regulator by enabling inflammatory response to disease causing agents on the one hand and by preventing a hyper-inflammatory response and autoimmune attack on the other.

Genetic polymorphisms within a single locus encoding the BACH2 transcription factor are associated with numerous autoimmune and allergic diseases including asthma, Crohn’s disease, celiac disease, vitiligo, multiple sclerosis, and type I diabetes. The BACH2 protein is normally found on the surface of CD4+ T-cells. These cells play a dual role within the immune system with some populations of CD4+ T-cells activating immune responses, while others, regulatory T-cells (Tregs), function to limit immune responses. An in-depth study of how the BACH2 regulatory factor controls the balance between the two types of immune response was conducted by investigators at the [US] National Institutes of Health (Bethesda, MD, USA).

The investigators worked with a genetically engineered mouse line that permitted silencing or activation of BACH2. They found that the loss of the BACH2 gene in CD4+ T-cells caused them to become inflammatory, even in situations that would normally result in the formation of protective regulatory cells. Mice lacking the BACH2 gene generated large numbers of inflammatory cells, and the animals died of autoimmune diseases within the first few months of life. Insertion of the BACH2 gene via gene therapy into BACH2-deficient cells restored their ability to produce regulatory cells.

"Although genes have been found that play specific roles in either inflammatory cells or regulatory cells, BACH2 regulates the choice between the two cell types, resulting in its critical role in maintaining the immune system’s healthy balance," said senior author Dr. Nicholas P. Restifo, an investigator at the [US] National Institutes of Health. "It is apt that the gene shares its name with the famous composer Bach, since it orchestrates many components of the immune response, which, like the diverse instruments of an orchestra, must act in unison to achieve symphonic harmony."

The study was published in the June 2, 2013, online edition of the journal Nature.

Related Links:

[US] National Institutes of Health



SLAS - Society for Laboratory Automation and Screening
BIOSIGMA S.R.L.
RANDOX LABORATORIES
comments powered by Disqus

Channels

Drug Discovery

view channel

Omega 3 Found to Improve Behavior in Children with ADHD

Supplements of the fatty acids omega 3 and 6 can help children and adolescents who have a specific kind of have attention deficit hyperactivity disorder (ADHD). Moreover, these findings indicate that a customized cognitive training program can improve problem behavior in children with ADHD. Statistics show that 3%–6%... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Lab Technologies

view channel
Image: On target: When researchers introduced nanobodies they made to cells engineered to express a tagged version of a protein in skeletal fibers known as tubulin (red), the nanobodies latched on. The cells above have recently divided (Photo courtesy of Rockefeller University).

Turning Antibodies into Precisely Tuned Nanobodies

New technology has the potential to create nanobodies making them much more accessible than antibodies for all sorts of research. Antibodies control the process of recognizing and zooming in on molecular... Read more

Business

view channel

Two Industry Partnerships Initiated to Fuel Neuroscience Research

Faster, more complex neural research is now attainable by combining technology from two research companies. Blackrock Microsystems, LLC (Salt Lake City, UT, USA), a developer of neuroscience research equipment, announced partnerships with two neuroscience research firms—PhenoSys, GmbH (Berlin, Germany) and NAN Instruments, Ltd.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.