Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

05 Mar 2017 - 09 Mar 2017
20 Mar 2017 - 23 Mar 2017
12 Apr 2017 - 14 Apr 2017

Intranasal Antibody Gene Transfer in Mice and Ferrets Protects Against Influenza Infection

By BiotechDaily International staff writers
Posted on 13 Jun 2013
Image
Image
Image: Senior author Dr. James M. Wilson (Photo courtesy of the University of Pennsylvania).
Image: Senior author Dr. James M. Wilson (Photo courtesy of the University of Pennsylvania).
ADVERTISEMENT
SARTORIUS AG
Transmission of the influenza virus was blocked in animal models by a gene therapy technique that introduced a neutralizing antibody gene directly into the cells lining the nose and respiratory system.

Investigators at the University of Pennsylvania (Philadelphia, USA) worked with mouse and ferret influenza models. To protect these animals against influenza A infection the investigators used a modified adeno-associated virus (AAV) vector to deliver the gene that encodes the broadly neutralizing monoclonal anti-influenza antibody FI6 directly into the nasopharyngeal mucosa of the mice and ferrets.

Test animals were exposed to lethal quantities of three strains of influenza serotype H5N1 and two strains of serotype H1N1, all of which were associated with historic human pandemics (including the H1N1 1918 "Spanish flu" pandemic).

The investigators reported in the May 29, 2013, online edition of the journal Science Translational Medicine that intranasal delivery of the FI6 gene afforded complete protection against influenza infection in both the mouse and ferret model systems.

“The experiments described in our paper provide critical proof-of-concept in animals about a technology platform that can be deployed in the setting of virtually any pandemic or biological attack for which a neutralizing antibody exists or can be easily isolated,” said senior author Dr. James. M. Wilson, professor of pathology and laboratory medicine at the University of Pennsylvania. “Further development of this approach for pandemic flu has taken on more urgency in light of the spreading infection in China of the lethal bird strain of H7N9 virus in humans.”


Related Links:
University of Pennsylvania



Channels

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Business

view channel

Collaborative Agreement to Aid in Setting Guidelines for Evaluating Potential Ebola Therapy

Cooperation between an Israeli biopharmaceutical company and medical branches of the US government is designed to set ground rules for continued evaluation of an experimental therapy for Ebola virus disease. RedHill Biopharma Ltd. (Tel Aviv, Israel), a biopharmaceutical company primarily focused on development and c... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.