Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

Enhanced Natural Killer Cell Activity Could Counter Influenza Virus Immune Response Evasion

By BiotechDaily International staff writers
Posted on 04 Jun 2013
Influenza viruses use their neuraminidase (NA) proteins to escape natural killer (NK) cell killing by impairing the NK cells' NKp46 surface receptor recognition of the viruses.

Investigators at the Hebrew University of Jerusalem (Israel) considered an additional function for neuraminidase in influenza virus infectivity that was linked to the role of NK cells in controlling influenza infection.

The investigators described in the April 18, 2013, issue of the journal Cell Reports an immune-evasion mechanism of influenza viruses that was mediated by the NA protein. By using various NA blockers, they showed that NA removed sialic acid residues from NKp46, and that this led to reduced recognition of HA. Furthermore, they provided in vivo and in vitro evidence for the existence of this NA-mediated, NKp46-dependent immune-evasion mechanism and demonstrated that NA inhibitors, which are commonly used for the treatment of influenza infections, were useful not only as blockers of virus budding but also as boosters of NKp46 recognition.

Influenza viruses mutate and change NA structure so that drugs directed at NA can no longer bind this protein. Nonetheless, this type of widely used drug has the effect of boosting NK cell activity, enabling them to better eliminate the influenza virus. The investigators stress, therefore, that efforts should be focused on developing effective new drugs that would maintain and enhance NK cell activity, without inducing changes in viral NA protein structure.




comments powered by Disqus

Channels

Drug Discovery

view channel

Molecule in Green Tea Used as Carrier for Anticancer Proteins

A molecule that is a key ingredient in green tea can be employed as a carrier for anticancer proteins, forming a stable and effective therapeutic nanocomplex. This new discovery could help to construct better drug-delivery systems. Some cancer treatments depend on medication comprising the therapeutic drug and a carrier... Read more

Lab Technologies

view channel
Image: The UC Santa Cruz Ebola Genome Portal contains links to the newly created Ebola browser and to scientific literature on the deadly virus (Photo courtesy of UCSC).

Ebola Genome Browser Now Online to Help Scientists’ Respond to Crisis

A US genomics institute has just released a new Ebola genome browser to help international researchers develop a vaccine and antiserum to help stop the spread of the Ebolavirus. The investigators led... Read more

Business

view channel

Interest in Commercial Applications for Proteomics Continues to Grow

Increasing interest in the field of proteomics has led to a series of agreements between private proteomic companies and academic institutions as well as deals between pharmaceutical companies and novel proteomics innovator biotech companies. Proteomics is the study of the structure and function of proteins.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.