Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

10 Oct 2016 - 12 Oct 2016
12 Nov 2016 - 16 Nov 2016

Blocking Constant Interferon Signaling Allows the Immune System to Clear Chronic Viral Infections

By BiotechDaily International staff writers
Posted on 23 Apr 2013
Print article
Blocking constant Type I interferon (IFN-I) signaling in mice diminished chronic immune activation and immune suppression and enabled the animals' immune system to rejuvenate and ultimately clear persistent viral infections.

Interferons (IFNs) are glycoprotein cytokines made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. They allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. Interferons were named after their ability to "interfere" with viral replication within host cells. IFNs have other functions: they activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T-lymphocytes; and they increase the ability of uninfected host cells to resist new viral infection. Certain symptoms, such as aching muscles and fever, are related to the production of IFNs during infection. While Type I interferons (IFN-I) are critical for antiviral immunity, chronic IFN-I signaling is associated with hyperimmune activation and disease progression in persistent infections.

Investigators at the University of California, Los Angeles (USA) injected mice suffering from chronic viral infections with an antibody that temporarily blocked IFN-I activity.

They reported in the April 12, 2013, issue of the journal Science that the blockade of IFN-I signaling diminished chronic immune activation and immune suppression, restored lymphoid tissue architecture, and increased immune parameters associated with control of virus replication, ultimately facilitating clearance of the persistent infection. The accelerated control of persistent infection induced by blocking IFN-I signaling required CD4 T-cells and was associated with enhanced IFN-gamma production.

“When cells confront viruses, they produce Type I interferons, which trigger the immune system’s protective defenses and sets off an alarm to notify surrounding cells,” said senior author Dr. David Brooks, assistant professor of microbiology, immunology, and molecular genetics at the University of California, Los Angeles. “Type-I interferon is like the guy in the watch tower yelling, "Red alert,” when the marauders try to raid the castle.”

“What we saw was entirely illogical,” said Dr. Brooks. “We had blocked something critical for infection control and expected the immune system to lose the fight against infection. Instead, the temporary break in IFN-I signaling improved the immune system’s ability to control infection. Our next task will be to figure out why and how to harness it for therapies to treat humans.”

Related Links:
University of California, Los Angeles



Print article

Channels

Drug Discovery

view channel
Image: Ginger is the source of a novel class of nanolipid transport vector (Photo courtesy of Georgia State University).

Ginger-Derived Doxorubicin-Loaded Nanovectors as Drug Delivery for Cancer Therapy

A novel type of nanoparticle drug transport system based on lipids isolated from ginger was used to deliver the toxic chemotherapeutic agent doxorubicin (Dox) to colon cancer cells with minimal damage... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Business

view channel

Collaborative Agreement to Aid in Setting Guidelines for Evaluating Potential Ebola Therapy

Cooperation between an Israeli biopharmaceutical company and medical branches of the US government is designed to set ground rules for continued evaluation of an experimental therapy for Ebola virus disease. RedHill Biopharma Ltd. (Tel Aviv, Israel), a biopharmaceutical company primarily focused on development and c... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.