Features | Partner Sites | Information | LinkXpress
Sign In
PZ HTL SA
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC

Omega-3 Fatty Acid Derivative Slows Tumor Growth by Blocking Formation of New Blood Vessels

By BiotechDaily International staff writers
Posted on 18 Apr 2013
A metabolite derived from an omega-3 fatty acid slows tumor growth by blocking the development of new blood vessels (angiogenesis).

Investigators at the University of California, Davis (USA) worked with cancer cell cultures and mouse cancer models to examine the effects of omega-3 and omega-6 fatty acids on tumor growth.

They reported in the April 3, 2013, online edition of the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS) that epoxy docosapentaenoic acid (EDP), a compound produced by the human body from the fish oil omega-3 fatty acid docosahexaenoic acid (DHA), inhibited primary tumor growth and metastasis by up to nearly 70%. The blocking of tumor growth was shown in a mouse cancer model to be due to EDP-mediated inhibition of vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2)-induced angiogenesis. In cancer cell cultures, EDP also suppressed the endothelial cell migration needed for new blood vessels.

In contrast, epoxyeicosatrienoic acids (EETs), metabolites of the omega-6 fatty acid arachidonic acid (ARA), slightly increased angiogenesis and tumor progression in mice.

“EDP works by a different mechanism than many current anticancer drugs that block angiogenesis,” said first author Dr. Guodong Zhang, a postdoctoral cancer researcher at the University of California, Davis. “Our investigation opens up a new understanding of the pathways by which omega-3 fatty acids exert their biologic effects. As far as we know, EDPs are the first signaling lipids that have been discovered to have such potent anticancer effects. Researchers may be able to use EDPs as structural targets to develop stable analogs as anticancer agents.”

Related Links:
University of California, Davis



comments powered by Disqus

Channels

Drug Discovery

view channel
Image: Disruption and removal of malaria parasites by the experimental drug (+)-SJ733 (Photo courtesy of the University of California, San Francisco).

Experimental Antimalaria Drug Induces the Immune System to Destroy Infected Red Blood Cells

An experimental drug for the treatment of malaria was found to induce morphological changes in infected erythrocytes that enabled the immune system to recognize and eliminate them. Investigators at... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Business

view channel

R&D Partnership Initiated to Reduce Development Time for New Drugs

nanoPET Pharma, GmbH (Berlin, Germany) signed an open-ended framework contract with the international pharmaceutical company Boehringer Ingelheim (Ridgefield, CT, USA). By developing customized contrast agents for research in both basic and preclinical studies, nanoPET Pharma will contribute to the enhancement of Boehringer... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.