Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING
PZ HTL SA

Five Major Psychiatric Disorders Share Common Genetics

By BiotechDaily International staff writers
Posted on 04 Apr 2013
Autism, attention deficit-hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder, and schizophrenia all share common genetic underpinnings, according to a new study.

Researchers at Massachusetts General Hospital (MGH; Boston, USA) analyzed genome-wide single-nucleotide polymorphism (SNP) data for the five disorders in 33,332 cases and 27,888 controls of European ancestry. The researchers characterized the cross-disorder effects of significant loci—previously identified for bipolar disorder and schizophrenia—and used polygenic risk-score analysis to examine the effects from a broader set of common variants. Pathway analyses were then used to establish the biological associations underlying the genetic overlap for the five disorders.

The results showed that SNPs on chromosomes 3p21 and 10q24, and SNPs within two L-type voltage-gated calcium channel subunits (CACNA1C and CACNB2), surpassed the cutoff for genome-wide significance in the primary analysis. Model selection supported the effects of these loci for several disorders, and polygenic risk scores showed cross-disorder associations, notably among adult-onset disorders. Pathway analysis supported a role for calcium channel signaling genes for all five disorders, and SNPs with evidence of cross-disorder association were enriched for expression quantitative trait loci (eQTL) markers in the brain. The study was published early online on February 28, 2013, in the Lancet.

“Our results suggest that voltage-gated calcium signaling, and, more broadly, calcium-channel activity, could be an important biological process in psychiatric disorders,” concluded lead author Jordan Smoller, MD, ScD, and colleagues. “The calcium-channel gene CACNA1C has been previously linked to bipolar disorder, schizophrenia, and major depressive disorder, as well as to Timothy syndrome, a developmental disorder that can include autism. The other calcium-channel gene has been linked to bipolar disorder in people of Han Chinese ethnicity.”

A SNP is a DNA sequence variation occurring when a single nucleotide in the genome differs between paired chromosomes, such as two sequenced DNA fragments from different individuals. SNPs occur in noncoding regions more frequently than in coding regions, or where natural selection is acting and fixating the allele of the SNP that constitutes the most favorable genetic adaptation; for example, affecting how humans develop diseases and how they respond to pathogens, chemicals, drugs, vaccines, and other agents.

Related Links:

Massachusetts General Hospital




Channels

Drug Discovery

view channel
Image: Chitosan is derived from the shells of shrimp and other sea crustaceans, including Alaskan pink shrimp, pictured here (Photo courtesy of NOAA - [US] National Oceanic and Atmospheric Administration).

Chitosan Treatment Clears the Way for Antibiotics to Eliminate Recurrent Urinary Tract Infections

Recurrent urinary tract infection was successfully resolved in a mouse model by treatment with the exfoliant chitosan followed by a round of antibiotics. Bacterial urinary tract infection (UTI), most... Read more

Biochemistry

view channel

Mitochondrial Cause of Aging Can Be Reversed

Researchers have found a cause of aging in lab animals that can be reversed, possibly providing an avenue for new treatments for age-related diseases including type 2 diabetes, cancer, muscle wasting, and inflammatory diseases. The researchers plan to begin human trials late 2014. The study, which was published December... Read more

Therapeutics

view channel

Cytokine Identified That Causes Mucositis in Cancer Therapy Patients

The action of the cytokine interleukin 1-beta (IL-1beta) has been found to underlie the onset of mucositis, a common, severe side effect of chemotherapy and irradiation of cancer patients. Mucositis occurs as a result of cell death in reaction to chemo- or radiotherapy. The mucosal lining of the mouth becomes thin, may... Read more

Lab Technologies

view channel
Image: Diagram of the apparatus for testing drug solubility (Photo courtesy of the University of Huddersfield).

Novel Apparatus Mimics the Human Digestive System for Oral Drug Studies

A team of British drug developers has created an instrument that mimics the human digestive system, which will allow them to accurately determine how orally-administered medications are dissolved and then absorbed.... Read more

Business

view channel

Analytical Sciences Trade Fair Declared a Rousing Success

Organizers of this year's 24th "analytica" biosciences trade fair have reported significant increases in both the number of visitors and exhibitors compared to the 2012 event. The analytica trade fair for laboratory technology, analysis, and biotechnology has been held at the Munich (Germany) Trade Fair Center every... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.