Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

Five Major Psychiatric Disorders Share Common Genetics

By BiotechDaily International staff writers
Posted on 04 Apr 2013
Autism, attention deficit-hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder, and schizophrenia all share common genetic underpinnings, according to a new study.

Researchers at Massachusetts General Hospital (MGH; Boston, USA) analyzed genome-wide single-nucleotide polymorphism (SNP) data for the five disorders in 33,332 cases and 27,888 controls of European ancestry. The researchers characterized the cross-disorder effects of significant loci—previously identified for bipolar disorder and schizophrenia—and used polygenic risk-score analysis to examine the effects from a broader set of common variants. Pathway analyses were then used to establish the biological associations underlying the genetic overlap for the five disorders.

The results showed that SNPs on chromosomes 3p21 and 10q24, and SNPs within two L-type voltage-gated calcium channel subunits (CACNA1C and CACNB2), surpassed the cutoff for genome-wide significance in the primary analysis. Model selection supported the effects of these loci for several disorders, and polygenic risk scores showed cross-disorder associations, notably among adult-onset disorders. Pathway analysis supported a role for calcium channel signaling genes for all five disorders, and SNPs with evidence of cross-disorder association were enriched for expression quantitative trait loci (eQTL) markers in the brain. The study was published early online on February 28, 2013, in the Lancet.

“Our results suggest that voltage-gated calcium signaling, and, more broadly, calcium-channel activity, could be an important biological process in psychiatric disorders,” concluded lead author Jordan Smoller, MD, ScD, and colleagues. “The calcium-channel gene CACNA1C has been previously linked to bipolar disorder, schizophrenia, and major depressive disorder, as well as to Timothy syndrome, a developmental disorder that can include autism. The other calcium-channel gene has been linked to bipolar disorder in people of Han Chinese ethnicity.”

A SNP is a DNA sequence variation occurring when a single nucleotide in the genome differs between paired chromosomes, such as two sequenced DNA fragments from different individuals. SNPs occur in noncoding regions more frequently than in coding regions, or where natural selection is acting and fixating the allele of the SNP that constitutes the most favorable genetic adaptation; for example, affecting how humans develop diseases and how they respond to pathogens, chemicals, drugs, vaccines, and other agents.

Related Links:

Massachusetts General Hospital




comments powered by Disqus

Channels

Drug Discovery

view channel

Molecule in Green Tea Used as Carrier for Anticancer Proteins

A molecule that is a key ingredient in green tea can be employed as a carrier for anticancer proteins, forming a stable and effective therapeutic nanocomplex. This new discovery could help to construct better drug-delivery systems. Some cancer treatments depend on medication comprising the therapeutic drug and a carrier... Read more

Biochemistry

view channel

Discovery of Pain Receptor on T-cells Could Help Treat Autoimmune Disorders

Researchers have discovered that T-cells are activated by a pain receptor. The new findings revealed that the receptor helps control intestinal inflammation in mice and that its activity can be adjusted, providing a potential new target for treating certain autoimmune disorders, such as Crohn’s disease and possibly multiple... Read more

Lab Technologies

view channel
Image: Yale West Campus is organized into research institutes and core facilities — all designed to promote collaboration and interdisciplinary dialogue (Photo courtesy of Yale University).

American and European Partners Establish a Microscopy Center of Excellence

A prominent American university has announced a partnership agreement with a major European producer of microscopes and imaging tools that will establish a center for the use of cutting-edge imaging technologies... Read more

Business

view channel

Interest in Commercial Applications for Proteomics Continues to Grow

Increasing interest in the field of proteomics has led to a series of agreements between private proteomic companies and academic institutions as well as deals between pharmaceutical companies and novel proteomics innovator biotech companies. Proteomics is the study of the structure and function of proteins.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.