Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Five Major Psychiatric Disorders Share Common Genetics

By BiotechDaily International staff writers
Posted on 04 Apr 2013
Print article
Autism, attention deficit-hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder, and schizophrenia all share common genetic underpinnings, according to a new study.

Researchers at Massachusetts General Hospital (MGH; Boston, USA) analyzed genome-wide single-nucleotide polymorphism (SNP) data for the five disorders in 33,332 cases and 27,888 controls of European ancestry. The researchers characterized the cross-disorder effects of significant loci—previously identified for bipolar disorder and schizophrenia—and used polygenic risk-score analysis to examine the effects from a broader set of common variants. Pathway analyses were then used to establish the biological associations underlying the genetic overlap for the five disorders.

The results showed that SNPs on chromosomes 3p21 and 10q24, and SNPs within two L-type voltage-gated calcium channel subunits (CACNA1C and CACNB2), surpassed the cutoff for genome-wide significance in the primary analysis. Model selection supported the effects of these loci for several disorders, and polygenic risk scores showed cross-disorder associations, notably among adult-onset disorders. Pathway analysis supported a role for calcium channel signaling genes for all five disorders, and SNPs with evidence of cross-disorder association were enriched for expression quantitative trait loci (eQTL) markers in the brain. The study was published early online on February 28, 2013, in the Lancet.

“Our results suggest that voltage-gated calcium signaling, and, more broadly, calcium-channel activity, could be an important biological process in psychiatric disorders,” concluded lead author Jordan Smoller, MD, ScD, and colleagues. “The calcium-channel gene CACNA1C has been previously linked to bipolar disorder, schizophrenia, and major depressive disorder, as well as to Timothy syndrome, a developmental disorder that can include autism. The other calcium-channel gene has been linked to bipolar disorder in people of Han Chinese ethnicity.”

A SNP is a DNA sequence variation occurring when a single nucleotide in the genome differs between paired chromosomes, such as two sequenced DNA fragments from different individuals. SNPs occur in noncoding regions more frequently than in coding regions, or where natural selection is acting and fixating the allele of the SNP that constitutes the most favorable genetic adaptation; for example, affecting how humans develop diseases and how they respond to pathogens, chemicals, drugs, vaccines, and other agents.

Related Links:

Massachusetts General Hospital




Print article

Channels

Drug Discovery

view channel
Image: A scanning electron microscope (SEM) image of methicillin-resistant Staphylococcus aureus bacteria (Photo courtesy of the CDC).

Drug Combination Cures MRSA Infection While Preventing Development of Resistance

Treatment with a combination comprising the well-known antibiotic cefdinir and the experimental drug TXA709 cured mice of drug-resistant staphylococcal infections while reducing the development of resistance.... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Lab Technologies

view channel
Image: A three-dimensional printer adapted for stem cell production (Photo courtesy of Nano Dimension).

Israeli Developers Demonstrate Prototype Three-Dimensional Bioprinter

Two Israeli companies have combined efforts in the development of three-dimensional printer technology for the production of stem cells. The three-dimensional print electronics developer Nano Dimension... Read more

Business

view channel

Acquisition to Boost Development of Drugs for Neurogenic Conditions

According to a recent announcement, a privately held biotechnology/drug development company is to be acquired by one of the major pharmaceutical manufacturers. The drug manufacturer Merck & Co. (Kenilworth, NJ, USA) has agreed to pay 500 million USD up front for Afferent Pharmaceuticals (San Mateo, CA, USA) and up... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.