Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING
JIB

Misuse of Antibiotics May Spur Bacterial Acquisition of Drug Resistance

By BiotechDaily International staff writers
Posted on 18 Mar 2013
Petri dish with bacterial colonies growing in a hazardous substrate (Photo courtesy of Dr. Mohammed Bakkali, Department of Genetics, University of Granada).
Petri dish with bacterial colonies growing in a hazardous substrate (Photo courtesy of Dr. Mohammed Bakkali, Department of Genetics, University of Granada).
A recent paper reviewed the scientific literature regarding acquisition of drug resistance by bacteria and advanced the theory that in most cases resistance is transferred by uptake of DNA that had been released by resistant organisms that had been broken open by the stress of antibiotic treatment.

The author, Dr. Mohammed Bakkali, professor of genetics at the University of Granada (Spain) reviewed some of the literature on bacterial acquisition of drug resistance and discussed four hypotheses on how and why bacteria take up DNA. He argued in the February 5, 2013, online edition of the journal Archives of Microbiology that DNA uptake by bacteria is an accidental by-product of bacterial adhesion and twitching motility. Adhesion and motility are generally increased in stressful conditions, which may explain why bacteria increase DNA uptake in these conditions.

This hypothesis has significant clinical implications and finds further support from the fact that antibiotics sometimes fail to eliminate the targeted bacterium while inevitably causing stress to others. The widespread misuse of antibiotics may thus not only be selecting for resistant strains, but may also be causing bacteria to take up more DNA with the consequent increase in the chances of acquiring drug resistance and virulence.

"Our current indiscriminate use of antibiotics not only selects the resistant bacteria, but also means that the bacteria take up more DNA, due to their increased motility in response to the stress that the antibiotic subjects them to," said Dr. Bakkali. "In this way, the nonresistant bacteria become resistant completely by accident on ingesting this DNA and can even become much more virulent, partly due to the stress we subject them to when we make an abusive use of antibiotics."

Related Links:

University of Granada



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: Differences in the structure of a small lung artery (top row) and heart cross section (lower row) of rodents without disease (far left column); with pulmonary hypertension (middle) and a diseased rodent treated with the HDL peptide (right). Note the much narrowed lung artery, and thick walls and larger chamber of the heart in the diseased animal and improvements with 4F peptide treatment (Photo courtesy of UCLA - University of California, Los Angeles).

Apolipoprotein A-1 Mimetic Peptide Reverses Pulmonary Hypertension in Rodent Models

A small peptide that mimics the activity of apolipoprotein A-1 (apo A-1), the main protein component of the high density lipoproteins (HDL), counteracted the effects of oxidized lipids and alleviated symptoms... Read more

Therapeutics

view channel
Image: Hair follicle (blue) being attacked by T cells (green) (Photo courtesy of Christiano Lab/Columbia University Medical Center).

Hair Restoration Method Clones Patients’ Cells to Grow New Hair Follicles

Researchers have developed of a new hair restoration approach that uses a patient’s cells to grow new hair follicles. In addition, the [US] Food and Drugs Administration (FDA) recently approved a new drug... Read more

Lab Technologies

view channel
Image: Leica Microsystems launches the inverted research microscope platform Leica DMi8 (Photo courtesy of Leica Microsystems).

New Inverted Microscope Designed to Readily Adapt to Changing Research Demands

A new inverted microscope for biotech and other life science laboratories was designed to readily accommodate modifications and upgrades to allow it to keep current with changing research demands and interests.... Read more

Business

view channel

Partnership Established to Decode Bowel Disease

23andMe (Mountain View, CA,USA), a personal genetics company, is collaborating with Pfizer, Inc. (New York, NY, USA), in which the companies will seek to enroll 10,000 people with inflammatory bowel disease (IBD) in a research project designed to explore the genetic factors associated with the onset, progression, severity,... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.