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11 Jun 2017 - 15 Jun 2017
19 Jun 2017 - 22 Jun 2017
New products on world’s medical product marketplace:


Image: Neisseria gonorrhoeae infection in human endocervical tissue is visualized by immunofluorescence microscopy. Bacterial (red) colonization causes columnar endocervical epithelial cells to shed and lose the barrier function, which allows bacteria to enter the endocervical tissue. For this image frozen tissue sections were stained for immunofluorescence with specific antibodies to the apical junctional protein ZO1 (green), N. gonorrhoeae (red), and the nuclear dye DAPI (blue) (Photo courtesy of Dr. Liang-Chun Wang, Department of Cell biology and Molecular Genetics, University of Maryland).

Tissue Model Used to Show Molecular Basis for Infection

A team of molecular microbiologists has explained the mechanism by which Neisseria gonorrhoeae, the bacterium that causes the urinary tract infection gonorrhea, invades and colonizes female genital tissues. More...
27 Apr 2017
Image: Cardiomyocytes from patients with Duchenne muscular dystrophy (DMD) corrected by CRISPR-Cpf1 reframing during stemness (right) show restored dystrophin expression (red), compared to uncorrected cells (left) (Photo courtesy of Science Advances).

Modified CRISPR Gene Editing Technique Repairs Dystrophin Mutation

Researchers used an alternative form of the CRISPR/Cas9 genome editing system to correct a mutation in heart cells derived from Duchenne muscular dystrophy patient skin cells and in a mouse model of the disease. More...
26 Apr 2017
Image: Lipid nanoprobes (blue, green, and yellow colored) spontaneously insert themselves into lipid bilayer of three extracellular vesicles. The cargo content of extracellular vesicles includes proteins, DNA, and RNA. The lipid nanoprobe-labeled extracellular vesicles are captured onto the surface of a magnetic bead (black, bottom) through interaction with conjugated avidin molecules (red) (Photo courtesy of Xin Zou / Pennsylvania State University).

Lipid Nanoprobe Method Enables Rapid Isolation of Extracellular Vesicles

A novel method reduces the amount time required to isolate extracellular vesicles (EVs) from culture media or blood plasma from hours to 15 minutes and does not require bulky or expensive equipment. More...
25 Apr 2017
Image: Human stem cells derived from skin samples have been induced to form tiny, three-dimensional, brain-like cultures that behave similarly to cells in the human midbrain (Photo courtesy of the University of Luxembourg).

Novel Organoid Culture System Used for Brain Cell Research

Brain cells - derived from pluripotent stem cells - growing in culture assemble into three-dimensional (3D), brain-like structures (organoids) that can serve as an experimental model system for studies into the cellular biology of the normal and diseased brain. More...
24 Apr 2017
Image: A micrograph of a mouse heart section showing human progenitor cells that formed functional human blood vessels. Purple color signifies human blood vessels, red staining signifies the blood vessels of the mouse that received the human cell implants (Photo courtesy of Dr. Jalees Rehman, University of Illinois).

Progenitor Cells Show Promise for Repairing Heart Attack Damage

Intermediate progenitor cells can be induced to develop into either endothelial cells (the type of cell that lines the walls of blood vessels) or into erythroblasts (the type of cells that mature into red blood cells) depending on the level of the transcription factor SOX17. More...
21 Apr 2017
Image: Circulating white blood cells, commonly referred to as leukocytes (large yellow clusters), can be seen lining an inflamed vessel wall along with leukosomes (small yellow speckles). Leukosomes, designed to mimic white blood cells, go unnoticed as they accumulate at the inflamed vessel (purple background), allowing them to concentrate their therapeutic payload at the target site (Photo courtesy of Houston Methodist Hospital).

Study Explains How Drug Carriers Interact with Immune System

Researchers seeking to develop nanoparticle-based drug delivery systems have determined how a specialized class of nanoparticles called leukosomes avoids immune system response in a mouse model system. More...
20 Apr 2017
Image: Human EPS cells (green) can be detected in both the embryonic part (left) and extra-embryonic parts (placenta and yolk sac, right) of a mouse embryo (Photo courtesy of the Salk Institute for Biological Studies).

New Chemical Cocktail Enables Study of Totipotent Stem Cells

A team of developmental molecular biologists has formulated a chemical cocktail that enables the derivation of stem cells with unique functional and molecular features from mice and humans including the ability to maintain a state of totipotency that allows them to develop into extra-embryonic tissues such as placenta. More...
19 Apr 2017

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BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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