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10 Oct 2016 - 12 Oct 2016
12 Nov 2016 - 16 Nov 2016


Image: A digitally colorized scanning electron micrograph (SEM) showing a blue-colored human neutrophil interacting with two pink-colored, rod-shaped Klebsiella pneumoniae bacteria (Photo courtesy of the NIAID).

Siderophores Induce Pneumonia-Promoting Changes in Lung Tissue

Siderophores, which are small, high-affinity iron chelating compounds secreted by some types of microorganisms, were found to act directly on the host to induce inflammatory cytokines and to aid in bacterial dissemination. More...
26 Sep 2016
Image: Lung cancer cells (Photo courtesy of SPL).

Novel Class of Nanoparticle Drug Transporters Selectively Target Lung Cancer Cells

A novel class of nanoparticles is able to deliver siRNA-based drugs selectively to lung cancer cells without harming normal cells. More...
26 Sep 2016
Image: A photomicrograph of bone marrow aspirate showing acute myeloid leukemia (AML) (Photo courtesy of Wikimedia Commons).

Inhibiting Enzyme Activity Overcomes Cell Differentiation Blockade

Inhibition of the enzyme dihydroorotate dehydrogenase (DHODH) was found to stimulate differentiation of acute myeloid leukemia (AML) cells, which reduced the cancer cell burden and promoted survival in human and mouse models. More...
26 Sep 2016

New Standardized Whole Genomes Released to Improve Quality Control

Researchers have expanded the set of tools for more accurate next generation sequencing (NGS) analysis of genomes by developing 4 additional reference materials (RMs) to run as controls for assessing performance of the equipment, chemistry, and data analysis being used. More...
26 Sep 2016
Image: Comparison of the structures of insulin in Conus geographus (red/white) and in humans (blue/white and green). The green B-chain terminal segment is absent in the C. geographus insulin (Photo courtesy of Dr. Mike Lawrence).

Snail Insulin Serves as Drug Development Model

A form of insulin isolated from a type of carnivorous marine snail lacks the segment of the B region that causes the protein to aggregate, which decreases the amount of time required by the hormone to influence glucose levels by a factor of three. More...
22 Sep 2016
Image: Researchers have discovered that the drug pioglitazone, used to treat diabetes, shows some ability to halt the overexpression of the protein NAF-1, which has been associated with the proliferation of breast cancer (Photo courtesy of Fang Bai, Rice University).

Stabilizing Iron-Sulfur Transport Clusters Reduces Size and Aggressiveness of Tumors

An international team of cancer researchers has identified a protein that, when overexpressed, enabled breast tumors to better withstand oxidative stress thereby becoming much larger and more aggressive. More...
21 Sep 2016
Image: A photo and a schematic illustration for a nanofluidic diffraction grating. Label-free signals based on a diffraction intensity change were attributed to amplification of DNA molecules, such as human papillomavirus and tubercle bacilli (Photo courtesy of Takao Yasui, Nagoya University).

Nanofluidic Diffraction Grating Technique for DNA Amplification May Replace PCR

A team of Japanese biophysicists suggests replacing the RT-PCR (real time polymerase chain reaction) technique with a rapid label-free detection method for real-time DNA amplification using a nanofluidic diffraction grating. More...
21 Sep 2016

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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