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Genomics/Proteomics

Image: A team of scientists has discovered an organic ‘smart’ biodegradable nanoparticle, named PEARL, that uses light and heat in a controlled manner to target and destroy tumors with bigger precision (Photo courtesy of the University Health Network).

Smart Nanoparticles Deliver Selective Heating to Kill Tumors

Cancer researchers have demonstrated a novel type of "smart" nanoparticle that can destroy a tumor through selective heating while causing minimal damage to surrounding normal tissues. More...
28 Jul 2016
Image: An atomic-level structural model of coxsackievirus B3 polymerase, which is responsible for making copies of the virus genome. The researchers replaced the orange phenylalanine 364 that is found in two different positions, with the turquoise tryptophan that is larger and covers both positions without needing to move. This causes fewer mutations to be made and reduces the ability of the virus to replicate and cause disease (Photo courtesy of Dr. Olve Peersen, Colorado State University).

RNA Polymerase Mutation Stabilizes Live Virus Vaccines

A team of molecular virologists has developed a more effective method for attenuating the replicative capabilities of the coxsackievirus and is using this platform to develop a vaccine for it and other positive-sense single-stranded RNA viruses, a group that includes poliovirus, dengue, and Zika. More...
28 Jul 2016
Image: Cells labeled to identify proteins that regulate the expression of a genetic switch for T-cells. On the right, T-cells where the switch is activated glow in yellow. On the left, the rainbow pattern, a hierarchical cluster analysis, tells investigators which genes are controlled by the switch. The horizontal stripes are the genes. If they stripes turn red going from left to right, it means they are turning on; if they turn blue, the genes are turning off (Photo courtesy of the California Institute of Technology).

Multitiered Molecular Control Mechanism Regulates T-cell Genetic Switch

Three distinct molecular processes act in a stage-specific manner to provide a multitiered system for regulating the T-cell developmental gene BCL11B (B-cell CLL/Lymphoma 11B). More...
27 Jul 2016
Image: Mitochondrial DNA (green spots) is found at points where mitochondria (blue) are in contact with the endoplasmic reticulum (red) (Photo courtesy of Dr. Samantha Lewis, University of California, Davis).

Mitochondrial Replication Mechanism Identified

The mechanism that controls division of mitochondria and replication of mitochondrial DNA (mtDNA) during the process of mitosis has been shown to be localized at sites where the mitochondria are in contact with the endoplasmic reticulum (ER). More...
26 Jul 2016
Image: In the mouse spleen, lymphoid tissue (purple) is responsible for launching an immune response to blood-born antigens, while red pulp (pink) filters the blood. Mutations in the C9ORF72 gene, the most common mutation found in ALS patients, can inflame lymphoid tissue and contribute to immune system dysfunction (Photo courtesy of Dr. Dan Mordes, Eggan Laboratory, Harvard Stem Cell Institute).

Loss-of-Function Mutation Causes ALS in Mouse Model

Neurological disease researchers working with a mouse model of amyotrophic lateral sclerosis (ALS) have shown that the condition is critically linked to a loss-of-function mutation in the C9ORF72 (chromosome 9 open reading frame 72) gene. More...
25 Jul 2016
Image: A strong biglycan signal (red) was detected in the tumor blood vessel area of a metastatic case (right) but was barely detected in the tumor tissues of a non-metastatic case (left) (Photo courtesy of Maishi N. et al., Scientific Reports).

Biglycan in the Tumor Microenvironment May Act As Metastasis Trigger

A small proteoglycan secreted from endothelial cells within the tumor microenvironment has been linked to the likelihood of the primary tumor metastasizing and freeing cells to travel to other parts of the body. More...
25 Jul 2016

Common Circulating Cell Clusters in Cancer Patients Characterized Anew

In a study of blood samples from colorectal cancer patients, researchers have now discovered the source of these cells and that they are not malignant, potentially opening up a new path to detect and inhibit the spread of cancer. More...
25 Jul 2016


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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