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06 Jun 2016 - 09 Jun 2016
22 Jun 2016 - 24 Jun 2016
04 Jul 2016 - 06 Jul 2016


Image: A dark field photomicrograph showing the spirochete bacterium Borrelia burgdorferi, the pathogen responsible for causing Lyme disease (Photo courtesy of the CDC).

Statins May Help Block Transmission of Lyme Disease

A recent study found that treatment with cholesterol-lowering statins reduced the number of Borrelia burgdorferi bacteria in rodents, which helped to block transmission of Lyme disease. More...
27 May 2016
Image: A fluorescent micrograph of glioblastoma cells (Photo courtesy of the International School of Advanced Studies).

Novel Gene Therapy Approach Kills Glioblastoma Tumors in Vitro and in VivoNovel Gene Therapy Approach Kills Glioblastoma Tumors in Vitro and in Vivo

Gene therapy to increase expression of the enzyme Emx2 (Homeobox protein Emx2) in glioblastoma multiforme (GBM) tumor cells was shown to destroy the cancer in vitro and prevent its recurrence in vivo. More...
27 May 2016
Image: Follicular helper T-cells (TFH cells, shown in blue) play a crucial role in the maturation of antibody-producing B-cells (shown in green). Activated B-cells give rise germinal centers (shown in red), where mature B-cells proliferate and produce highly specific antibodies against pathogens. Top left: normal germinal center in a mouse tonsil. All others: Germinal centers fail to form when the interaction between ICOS and TBK1 is interrupted (Photo courtesy of Dr. Kok-Fai Kong, La Jolla Institute for Allergy and Immunology).

Molecular Pathway Controlling High-affinity Antibody Production Identified

A molecular pathway has been identified that controls formation of follicular helper T-cells (TFH cells) germinal centers and production of high-affinity antibodies through interaction with the inducible costimulator ICOS via the kinase TBK1 (TANK-binding kinase 1). More...
19 May 2016
Image: A photomicrograph showing multiple myeloma cells in the bone marrow (Photo courtesy of the University of Miami School of Medicine).

New Multiple Myeloma Mouse Model Should Advance Drug Development Efforts

A recently developed multiple myeloma mouse model is expected to aid in understanding the pathology of the disease and serve as a platform for preclinical testing of potential therapeutic agents. More...
18 May 2016
Image: Researchers have shown how controlling cholesterol metabolism in pancreatic cancer cells reduces metastasis to other organs, pointing to a potential new treatment. Findings showed a higher number of metastatic lesions in organs of untreated and treated mice, shown at top and bottom, respectively (Photo courtesy of Dr. Junjie Li, Purdue University).

Inhibition of Cholesterol Esterification Suppresses Growth of Pancreatic Cancer Cells

A team of cancer researchers has suggested that controlling cholesterol metabolism within tumor cells represents a novel approach towards treating the disease. More...
18 May 2016
Image: A structural model of the cathepsin S (CTSS) protein (Photo courtesy of Wikimedia Commons).

Protein Imbalance Linked to Presence of Biomarker in Tears of Sjögren’s Syndrome Patients

Increased expression of cathepsin S (CTSS) activity has emerged as a unique biomarker in the tears of Sjögren’s syndrome (SS) patients. More...
17 May 2016
Image: Molecular structure of factor H bound to C3b. In order to avoid self-attack, regulatory proteins such as factor H bind with C3b, a central component of the enzyme C3 convertase, to help the immune system recognize the body’s own tissue and keep complement in check (Photo courtesy of the University of Pennsylvania School of Medicine).

Antibodies against Complement Factor H Selectively Destroy Tumor Cells

Cancer researchers have identified and produced a monoclonal antibody that destroys tumor cells by blocking the activity of the protective protein complement factor H (CFH). More...
17 May 2016

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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