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05 Mar 2017 - 09 Mar 2017
20 Mar 2017 - 23 Mar 2017
12 Apr 2017 - 14 Apr 2017

Genomics/Proteomics

Image: A photomicrograph of a mouse macrophage of extending pseudopodia to engulf two particles, possibly pathogens (Photo courtesy of Wikimedia Commons).

HDL Increases Macrophage Immune Response

While high-density lipoproteins (HDL) protect against atherosclerosis by inhibiting inflammation in the endothelial and smooth muscle cells that comprise the arterial wall, in immune macrophages HDL instead increases the inflammatory response. More...
01 Dec 2016
Image: The neuromuscular junction is the synapse where motor neurons communicate with muscle to initiate voluntary movement. A healthy neuromuscular junction (yellow) is characterized by perfect apposition between the motor neuron (green) and nicotinic acetylcholine receptors on the muscle (red). This synapse is damaged early in ALS, a change believed to contribute the onset and progression of the disease (Photo courtesy of the Virginia Tech Carilion Research Institute).

Faulty Protein Interaction Disrupts Neuromuscular Junctions and Triggers ALS

Humans and mice are protected from developing amyotrophic lateral sclerosis (ALS) by the action of muscle fibers that secrete and concentrate the fibroblast growth factor binding protein 1 (FGFBP1) at neuromuscular junctions. More...
01 Dec 2016
Image: A micrograph of cells in the thymus, an organ located just above the heart that trains immune T-cells to defend the body against viruses and bacteria (Photo courtesy of the Walter and Eliza Hall Institute).

Study Explains How Protein Complex Mediates T-cell Development

A recent paper extended our understanding of how T-cells develop into critical components of the immune system that are able to fight off pathogens without going out of control and triggering an autoimmune response. More...
30 Nov 2016
Image: Two fluorescent microscopy images of intestinal organoids growing in synthetic hydrogels (Photo courtesy of N. Gjorevski, Ecole Polytechnique Fédérale de Lausanne).

Synthetic Hydrogel System for Growth of Intestinal Organoids

A process for using artificial hydrogel matrices to grow miniature organs (organoids) derived from stem cell precursors was described in a recent paper. More...
30 Nov 2016
Image: The structural model of IL-10 (Photo courtesy of Wikimedia Commons).

Anti-inflammatory Cytokine Prevents Development of Insulin Resistance in Model

The anti-inflammatory cytokine interleukin 10 (IL-10) was found to prevent the age-related development of insulin resistance in the muscles of a genetically engineered mouse model. More...
29 Nov 2016
Image: A photomicrograph of neurons growing in culture. The colors highlight the human tau protein in green, a structural component in red, and the DNA inside the cell nucleus in blue (Photo courtesy of Dr. Lars Ittner, University of New South Wales).

Phosphorylation of Tau Protein Inhibits Amyloid-beta Toxicity in Alzheimer’s Model

A team of Australian Alzheimer's disease (AD) researchers have presented evidence suggesting that phosphorylation of tau protein in the early stages of the disease acts to protect against the toxicity of amyloid-beta (Abeta) plaques, and that this protective effect disappears as the disease progresses. More...
29 Nov 2016
Image: A fibroblast undergoing ferroptosis (Photo courtesy of Helmholtz Zentrum München).

Blocking the Acsl14 Enzyme Prevents Ferroptosis-Linked Cell Death

Inhibiting the enzyme Acsl4 (acyl-CoA synthetase long-chain family member 4), which is involved in fatty acid metabolism, has been postulated to be a viable therapeutic approach to preventing ferroptosis-related diseases. More...
25 Nov 2016


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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