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Genomics/Proteomics

Advanced Gene Profiling Technique Highlights Genetic Differences between Low and High Responders to the Rubella Vaccine

A set of 27 genes have been identified that are expressed differently in individuals that display low or high immune responses following vaccination with a standard rubella vaccine. More...
16 May 2013
Image: Senior author Dr. Gregory Poland (Photo courtesy of the Mayo Clinic).

Silencing the HMGA1 Gene Blocks Metastasis in Breast Cancer

Blocking the activity of the protein encoded by the HMGA1 gene in breast cancer cells renders them less aggressive and diminishes their ability to metastasize. More...
15 May 2013
Image

Genome of the Lone Star Virus Quickly Unmasked by Ultradeep Gene Sequencing

Virologist have used next generation "ultradeep" gene sequencing and analysis coupled with de novo synthesis of the viral genome to assign a unique example of the Lone Star virus to the bunyavirus family of tick-borne viruses. More...
13 May 2013
Image: Senior author Dr. Charles Chiu (Photo courtesy of Susan Merrell, University of California, San Francisco).

A Molecular Hinge Allows Transport Proteins to Move Neurotransmitters Across Brain Cell Membranes

An international team of molecular biologists has developed a model that shows how components of a protein transport complex act as a molecular hinge to move neurotransmitters across brain cell membranes. More...
13 May 2013
Image: Senior author Dr. Shimon Schuldiner (Photo courtesy of the Hebrew University of Jerusalem).

Molecular Signaling in the Hypothalamus Modulates the Aging Process

A recent paper linked the aging process to molecular signals produced in the hypothalamus, a small region of the brain that is responsible for maintaining normal function for numerous bodily processes, including blood pressure, body temperature, and glucose levels. More...
13 May 2013
Image: Senior author Dr. Dongsheng Cai (Photo courtesy of Albert Einstein College of Medicine, Yeshiva University).

Mutation That Blocks p53-Mediated DNA Repair Identified in Multiple Types of Cancer

A mutation in the protein phosphatase, Mg2+/Mn2+ dependent, 1D gene results in production of a C-terminally truncated form of the protein Wip1, which is a stable inhibitor of the p53 tumor suppressor. More...
13 May 2013
Image: Researchers tracked down mutations in the phosphatase Wip1 in cancer cells that enhance the protein’s ability to shut down p53 and stymie the DNA damage repair process. The panel shows how cells respond to a dose of radiation that normally stops cells from dividing. The top row shows the cells one hour after the radiation, and the bottom row shows them 17 hours afterward. Cells with truncated Wip1 (left column) progress normally toward the point of cell division (orange nuclei), but most cells lacking truncated Wip1 (right column) fail to progress (red nuclei) (Photo courtesy of  Dr. Indra Shaltiel, The Netherlands Cancer Institute).

Silencing the HMGA1 Gene Blocks Metastasis in Breast Cancer

Blocking the activity of the protein encoded by the HMGA1 gene in breast cancer cells renders them less aggressive and diminishes their ability to metastasize. More...
13 May 2013
Image: Senior author Dr. Linda Resar (Photo courtesy of Johns Hopkins University).
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BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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20 Jul 2013 - 24 Jul 2013


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