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Genomics/Proteomics

Image: To adhere to catheters and start urinary tract infections, bacteria extend microscopic fibers with sticky proteins at their ends. Researchers have developed a vaccine that blocks the EbpA protein, visible as a white bulge above, and stops infections in mice (Photo courtesy of Dr. John Heuser, Washington University School of Medicine).

Blocking Binding of Bacteria to Fibrinogen Prevents Biofilm Formation and Catheter-Associated Bladder Infection in Mice

A team of molecular microbiologists has identified and targeted a critical step in biofilm formation and developed a vaccine that prevents catheter-associated urinary tract infections in mice.  More...
30 Sep 2014
Image: Illustration of the apoER2 receptor protein shows the structure of the entire protein in detail (Photo courtesy of Wikimedia Commons).

Risk of Cardiovascular Disease Linked to Apolipoprotein E Variants

The apoE4 variant form of circulating apolipoprotein E leads to increased risk of cardiovascular disease by blocking binding of the normal apoE3 form to the apoliprotein E receptor 2 in the membranes of endothelial cells lining the walls of blood vessels and by interacting with the receptor without stimulating production of anti-inflammatory nitric oxide.   More...
29 Sep 2014

MicroRNA Mimic Shown to Reverse Effects of Pulmonary Fibrosis

A potential new treatment that reverses the effects of pulmonary fibrosis, a respiratory disease in which scars develop in the lungs and greatly suppress breathing, is being assessed by scientists.  More...
29 Sep 2014
Image: Formation of circRNA—in this case circMbl—competes with the process of linear splicing (Photo courtesy of The Hebrew University of Jerusalem).

New Findings Implicate Circular RNA in the Development of Neurodegenerative Diseases

A recent paper described new findings that shed light on the production and function of circular RNA molecules in animal neuronal tissue.  More...
28 Sep 2014

Activating Gene Slows the Aging Process by “Remote Control”

Biologists have identified a gene that can delay the aging process when triggered remotely in vital organs. The life scientists, working with fruit flies, switched on a gene called AMPK, which is a major energy sensor in cells.   More...
28 Sep 2014

Large Genetic Study Identifies New Prostate Cancer Loci

Data obtained during a large genetic screening study have added 23 new genetic variants to the known loci linked to development of prostate cancer.  More...
21 Sep 2014
Image: Investigators identified individual unlabeled proteins by the weak shadow that the biomolecules produce when they scatter laser light (Photo courtesy of the Max Planck Institute for the Science of Light).

Laser Scattering Technique Detects Single Molecules

A recent paper described a novel technique for the label-free detection of single biomolecules such as tumor markers, proteins, or RNA fragments.  More...
21 Sep 2014


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
 
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