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Genomics/Proteomics

Image: Blocking the activity of HSP101 may imprison the malaria parasite inside its protective vacuole within the red blood cell. In the electron micrograph, the malaria parasites appear in blue and uninfected red blood cells are shown in red (Photo courtesy of the [US] National Institute of Allergy and Infectious Diseases).

Heat Shock Protein Plays Critical Role in Malaria Parasite Protein Trafficking

A pair of recent papers described the molecular operators that enable the malaria parasite Plasmodium falciparum to export a large variety of proteins across the parasitophorous vacuolar membrane within which the parasite resides into the cytoplasm of the infected red blood cell. More...
29 Jul 2014

Molecular Pathway Decreases Cell Adhesion and Initiates Metastasis

A recent paper outlined a molecular pathway that enables lung cancer cells to migrate away from the site of the primary tumor and become established in other parts of the body.  More...
28 Jul 2014
Image: Microcomputed tomography images (top) and histology images (bottom) of the knees of mice fed a very high fat diet containing omega-3 fatty acid supplement (left) or only omega-6 fatty acids (right) after a knee injury. The omega-6 diet showed abnormal bone remodeling and calcified tissue formation in the joint (white arrow). The omega-6 diet also showed significant loss of cartilage (red staining, yellow arrowhead) and increased joint inflammation (Photo courtesy of Duke University).

Dietary Omega-3 Fatty Acids Moderate Severity of Osteoarthritis in a Mouse Model

Researchers working with an osteoarthritis obese mouse model found that the fat content of the animals' diet contributed more to the development or arrest of OA than did body weight. More...
22 Jul 2014

Cinnamon Feeding Blocks Development of Parkinson's Disease in Mouse Model

A team of neurological researchers has identified a molecular mechanism by which cinnamon acts to protect neurons from damage caused by Parkinson's disease (PD) in a mouse model of the syndrome. More...
22 Jul 2014
Image: Scanning electron micrograph of cultured human neuron from induced pluripotent stem cell (Photo courtesy of the University of California, San Diego).

Induced Stem Cells Show Genetic Abnormalities Not Found in Embryonic Stem Cells

All stem cells are not created equal: genomic evaluation revealed that the genome of stem cells generated from adult cells differed considerably from that of "gold standard" human embryonic stem cells.  More...
15 Jul 2014

Bacterial Populations Rapidly Evolve a Time-linked Tolerance to Antibiotics

A team of molecular microbiologists has found that some types of bacteria develop tolerance towards antibiotic treatment by "learning" how to time the length of exposure to the drug and evolving an extended period of dormancy that protects the organisms from the effects of the antibiotic.   More...
14 Jul 2014
Image: Human gastrointestinal cells from patients were engineered to express insulin (fluorescent green) in the laboratory (Photo courtesy of Columbia University).

Deletion of the FOXO1 Gene Transforms Intestinal Cells into Insulin Producers

After having demonstrated that gut endocrine progenitor cells of mice could be differentiated into glucose-responsive, insulin-producing cells by elimination of the transcription factor FOXO1, diabetes researchers have extended these findings by obtaining similar results with human gut endocrine progenitor and serotonin-producing cells.  More...
13 Jul 2014


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
 
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