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Image: The photo shows a mouse pancreatic islet as seen by light microscopy. Beta cells can be recognized by the green insulin staining. Glucagon is labeled in red and the nuclei in blue (Photo courtesy of Wikimedia Commons).

Regenerative Potential Is a Trait of Mature Tissues, Not an Innate Feature of Newly Born Cells

Diabetes researchers have found that the ability of insulin-producing beta cells to replicate and respond to elevated glucose concentrations is absent in very young animals and does not appear until after weaning.  More...
25 Mar 2015
Image: Comparing sections of cortex from a control mouse (left) to a mouse with a presenilin-1 mutation (right). The dashed line indicates the surface of the brain. Presenilin-1 mutations decrease gamma-secretase activity and cause features of neurodegeneration, including shrinkage of the cortex, as shown above (Photo courtesy of Dr. Raymond Kelleher and Dr. Jie Shen, Harvard Medical School).

Presenilin Gene Mutation Linked to Familial form of Alzheimer's Disease

Results obtained in studies using a genetically engineered mouse model of hereditary Alzheimer's disease pointed to the importance of reduced gamma-secretase activity caused by a mutation in the presenilin gene.  More...
24 Mar 2015

The Captureseq Technique Is More Accurate for Low Expressing Genes and Long Non-Coding RNAs

The powerful new CaptureSeq technique for gene analysis was shown to be superior for detecting and quantifying genes with low expression while showing little technical variation and accurately measured differential expression of long non-coding RNAs.  More...
24 Mar 2015
Image: The Mseek technique uses enzymes to purify mitochondrial DNA by deleting the nuclear DNA, leaving behind the pure mitochondrial DNA to be sequenced (Photo courtesy of the Middle East Molecular Biology Society).

New Tool Facilitates Study of Mitochondrial DNA Variation

A new tool has been developed that enables researchers to study mitochondrial heteroplasmy and which will aid them in achieving better understanding of its impact on health and disease.  More...
17 Mar 2015

Two Proteins Critical for Circadian Cycles Protect Cells from Mutations

Scientists have discovered that two proteins critical for maintaining healthy day-night cycles also have an unexpected role in DNA repair and protecting cells against genetic mutations that could lead to cancer and other diseases.   More...
17 Mar 2015

Experimental Brain Cancer Drug Disrupts Intracellular Endosome Activity

Cancer researchers have described the mechanism by which the low molecular weight compound 5-Benzylglycinyl-amiloride disrupts the internal regulation of brain cancer cells in a manner that triggers the pathway for programmed cell death.   More...
16 Mar 2015
Image: Photomicrograph of mouse embryonic cells that have been programmed to overexpress Higd1a protein (shown in green). This protein slows down the metabolism of cancer cells, allowing them to hibernate and survive long-term (Photo courtesy of the University of California, San Francisco).

Oxygen Deprivation Activates Tumor Survival Genes in Solid Tumors

A possible new approach for treating reoccurring tumors would target the protein hypoxia-inducible gene domain family member 1A.  More...
15 Mar 2015

BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
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