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Genomics/Proteomics

Image: Lipopolysaccharides (LPS) are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond. They are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals (Photo courtesy of Wikimedia Commons).

Elevated Levels of IgG2 Antibodies Protect Some Types of Gram-Negative Bacteria

The finding that an overabundance of a certain class of antibodies protects some bacteria from the effects of antibiotics has marked implications for our understanding of the protection generated by natural infections and for the design of vaccines, which should avoid inducing such inhibitory antibodies.  More...
27 Aug 2014

Partnership Established to Decode Bowel Disease

23andMe, a personal genetics company, is collaborating with Pfizer, in which the companies will seek to enroll 10,000 people with inflammatory bowel disease in a research project designed to explore the genetic factors associated with the onset, progression, severity, and response to treatments for IBD.  More...
25 Aug 2014
Image: Microscopic view of a section of mouse brain shows tiny clusters of tumor cells growing along existing brain blood vessels (Photo courtesy of the University of Michigan).

Brain Tumors Grow by Tapping Preexisting Blood Vessels for Nutrients

Findings from a new study on how tumors grow and spread in the brain may cause cancer researchers to rethink treatment options based on drugs that block angiogenesis.  More...
24 Aug 2014
Image: The presence of p45 (green staining) and p75 (red staining) indicates that motor neurons increase both p45 and p75 expression after sciatic nerve injury in an animal (Photo courtesy of the Salk Institute for Biological Studies).

Blocking Nerve Growth Factor Receptor Enables Human Nervous System Regeneration

The mystery of why the human nervous system is unable to regenerate may have been at least partially solved with the identification of a protein called p75 that seems to block the repair of damaged nerve cells.   More...
20 Aug 2014
Image: In mice whose brain tumor cells (in green) could not make galectin-1, the body’s immune system was able to recognize and attack the cells, causing them to die. In this microscope image, the orange areas show where tumor cells had died in just the first three days after the tumor was implanted in the brain. Six days later, the tumor had been eradicated (Photo courtesy of the University of Michigan).

Surface Protein Protects Brain Tumor Cells from Immune Attack

Malignant glioma brain tumor cells suppress the natural killer cell immune response by over expressing the surface protein galectin-1, and suppression of this protein renders the tumor cells susceptible to destruction by the immune system.   More...
19 Aug 2014
Image: Extension of human axons into host adult rat white matter and gray matter three months after spinal cord injury and transplantation of human induced pluripotent stem cell-derived neurons. Green fluorescent protein identifies human graft-derived axons, myelin (red) indicates host rat spinal cord white matter and blue marks host rat gray matter (Photo courtesy of UCSD – University of California, San Diego School of Medicine).

Grafted Human Stem Cells Experience Drastic Growth in Spinal Cords of Rats

Scientists have reported that neurons derived from human induced pluripotent stem cells and grafted into rats after a spinal cord injury produced cells with tens of thousands of axons extending virtually the entire length of the animals’ central nervous system.  More...
18 Aug 2014
Image: Using CRISPR to silence the E6 gene in Human Papilloma Virus, researchers were able to restart the cervical carcinoma cell\'s natural self-destruct mechanisms, including the gene p53. Similar results were obtained against the HPV-E7 gene, turning on the carcinoma\'s Rb gene (Photo courtesy of Duke University).

Gene Therapy Reactivates Cell Death Pathways in Cervical Cancer Cells

A team of molecular virologists has presented evidence demonstrating the possibility of developing anticancer therapies based on viral vectors that transfect carcinoma cells with RNA-protein complexes capable of reactivating genes in the cancer cells that cause cell cycle arrest and eventual cell death.  More...
18 Aug 2014


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
 
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