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Genomics/Proteomics

Image: An activated PTEN dimer that contains two non-mutant proteins (A) can transform the functional lipid (D) on the cellular membrane (E) into a chemical form that tunes down cancer predilection. Dimers that contain a mutated protein (B) or PTEN monomers cannot transform the functional lipid (Photo courtesy of Carnegie Mellon University).

PTEN Requires a Stable Dimer Configuration to Effectively Suppress Tumor Growth

Molecular structural analysis has shown that the PTEN tumor suppressor can function effectively only when two wild-type alleles are present to form a stable dimer that can act on lipids in the cell membrane.  More...
01 Sep 2015

Monkeys Protected from MERS Infection by Synthetic DNA Vaccine

A synthetic DNA vaccine directed against the Middle East Respiratory Syndrome's spike protein was found to completely protect rhesus macaques from developing pneumonia after having been exposed to the live virus.  More...
01 Sep 2015
Image: Researchers engineered cultured cells to contain a red marker that moves into the nucleus upon HCV infection. Nothing happened when normal cells were exposed to HCV (top), but when the researchers expressed the protein SEC14L2, some nuclei changed color from blue to purple (bottom) (Photo courtesy of Laboratory of Virology and Infectious Disease at The Rockefeller University).

DNA Found That Enables Growth of Wild-Type Hepatitis C Virus in Cell Cultures

A team of molecular virologists has found that the overexpression of a particular DNA in liver cancer cells enables these cells to maintain the growth of wild-type Hepatitis C virus in culture.  More...
31 Aug 2015
Image: Liver-on-chip device and microscopic image of bionic liver (Photo courtesy of Dr. Yaakov Nahmias, The Hebrew University of Jerusalem).

Novel Microreactor Enables Evaluation of Drug Toxicity on the Liver

A novel three-dimensional microreactor capable of maintaining metabolically active liver cells in vitro for over 28 days under stable oxygen gradients that mimic the in vivo microenvironment of the liver was used to determine why the painkiller acetaminophen causes damage to this organ.  More...
26 Aug 2015
Image: Researchers used Time-lapse Imaging Microscopy In Nanowell Grids (TIMING) to demonstrate that CD4+ CD19-chimeric antigen receptor (CAR+) T-cells participate in multi-killing of tumor cells with slower kinetics of killing than CD8+CAR+T cells but high motility subgroups of both T-cell subsets have similar kinetics (Photo courtesy of the University of Houston).

Novel Algorithms Allow Automated Monitoring of Individual Cell-to-Cell Interactions

A novel combination of microscopy, time-lapse video recording, and analytical algorithms enables tracking of individual cell-to-cell interactions, which will boost research towards cancer immunotherapy treatments.  More...
25 Aug 2015
Image: Skin cells (keratinocytes) treated with an agent that activates TLR3 (dsRNA) can turn on important regeneration proteins, like Wnt7b (green) (Photo courtesy of Johns Hopkins University).

Molecular Pathway Leads to Skin and Hair Regeneration After Injury

The ability of the skin to regenerate after injury has been linked to stimulation of Toll-Like Receptor 3 by double-stranded RNA released by the damaged skin.  More...
25 Aug 2015
Image: Cells with a nucleus (labeled blue), were originally human fibroblasts, some of which have been converted to neurons that produce serotonin (green) while others have been converted to produce another neuron-specific protein. Yellows, greens, and other colors result from overlapping labels (Photo courtesy of Dr. Jian Feng, University at Buffalo).

Method for In Vitro Neuron Culture Will Advance Serotonin Research

A method has been developed that enables human serotonin-producing neurons, generated from transformed fibroblasts, to be grown in culture for use as a tool for research and drug discovery on many serotonin-related mental disorders.  More...
24 Aug 2015


BioResearch's Genomics/Proteomics channel brings the latest research news on the proteome, the epigenome, metabolomics, their tools and methods.
 
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