Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING
JIB

Polyphenol-Rich Cocoa Extracts Protect Against Alzheimer's Disease

By BiotechDaily International staff writers
Posted on 08 Jul 2014
Image: Dutch process cocoa (left) compared to natural cocoa (right) (Photo courtesy of Wikimedia Commons).
Image: Dutch process cocoa (left) compared to natural cocoa (right) (Photo courtesy of Wikimedia Commons).
A recent paper suggested that flavonol-rich cocoa extracts interfere with the processes that lead to the development of Alzheimer's disease.

Alzheimer's disease (AD) is characterized by pathological aggregates of amyloid peptide-beta (Abeta) and tau protein. Currently available therapies ease AD symptoms but do not slow progression of the disease.

Previous studies have reported that polyphenol-rich diets reduce the risk for developing AD. In the present study, investigators at the Icahn School of Medicine at Mount Sinai (New York, NY, USA) evaluated the AD disease-modifying effects of cocoa, a rich source of flavanols, which are a class of polyphenols.

The investigators tested the effects of three different cocoa extracts (Natural, Dutched, and Lavado), on Abeta42 and Abeta40 oligomerization, using the photo-induced cross-linking of unmodified proteins technique. To assess the effects of cocoa extracts on synaptic function, they measured long term potentiation in mouse brain hippocampal slices exposed to oligomeric Abeta.

Results published in the June 23, 2014, online edition of the Journal of Alzheimer’s Disease revealed that cocoa extracts were effective in preventing the oligomerization of Abeta, with Lavado extract being most effective. Lavado extract, but not Dutched extract, was effective in restoring the long term potentiation response reduced by oligomeric Abeta. The Dutch process lowers acidity, increases solubility, enhances color, and smoothes flavor. Compared to other processes, Dutch process chocolate contains lower amounts of flavonols.

“Our data suggest that Lavado cocoa extract prevents the abnormal formation of Abeta into clumped oligomeric structures, to prevent synaptic insult and eventually cognitive decline,” said senior author Dr. Giulio Maria Pasinetti, professor of neurology at the Icahn School of Medicine at Mount Sinai. “Given that cognitive decline in Alzheimer’s disease is thought to start decades before symptoms appear, we believe our results have broad implications for the prevention of Alzheimer’s disease and dementia.”

“There have been some inconsistencies in medical literature regarding the potential benefit of cocoa polyphenols on cognitive function,” said Dr. Pasinetti. “Our finding of protection against synaptic deficits by Lavado cocoa extract, but not Dutched cocoa extract, strongly suggests that polyphenols are the active component that rescue synaptic transmission, since much of the polyphenol content is lost by the high alkalinity in the Dutching process.”

Related Links:

Icahn School of Medicine at Mount Sinai



comments powered by Disqus

Channels

Drug Discovery

view channel

Molecule in Green Tea Used as Carrier for Anticancer Proteins

A molecule that is a key ingredient in green tea can be employed as a carrier for anticancer proteins, forming a stable and effective therapeutic nanocomplex. This new discovery could help to construct better drug-delivery systems. Some cancer treatments depend on medication comprising the therapeutic drug and a carrier... Read more

Lab Technologies

view channel
Image: The UC Santa Cruz Ebola Genome Portal contains links to the newly created Ebola browser and to scientific literature on the deadly virus (Photo courtesy of UCSC).

Ebola Genome Browser Now Online to Help Scientists’ Respond to Crisis

A US genomics institute has just released a new Ebola genome browser to help international researchers develop a vaccine and antiserum to help stop the spread of the Ebolavirus. The investigators led... Read more

Business

view channel

Interest in Commercial Applications for Proteomics Continues to Grow

Increasing interest in the field of proteomics has led to a series of agreements between private proteomic companies and academic institutions as well as deals between pharmaceutical companies and novel proteomics innovator biotech companies. Proteomics is the study of the structure and function of proteins.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.