Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
PZ HTL SA
GLOBETECH PUBLISHING LLC

Cholesterol Inhibitor Blocks Breast Cancer Growth in Mouse Model

By BiotechDaily International staff writers
Posted on 02 Jul 2014
Image: Space-filling model of the cholesterol molecule (Photo courtesy of Wikimedia Commons).
Image: Space-filling model of the cholesterol molecule (Photo courtesy of Wikimedia Commons).
A low molecular weight drug that inhibits cholesterol biosynthesis was found to block the growth of breast tumors by modifying the ratio of proliferative and antiproliferative estrogen receptors.

Investigators at the University of Missouri (Columbia, USA) used breast cancer cell cultures for in vitro studies and BT-474 breast tumor xenografts in nude mice for in vivo studies of tumor progression. They treated these animals with the drug RO 48-8071, a small-molecule inhibitor of oxidosqualene cyclase (OSC, a key enzyme in cholesterol biosynthesis).

Results published in the July 2014 issue of the journal Breast Cancer Research and Treatment revealed that in vitro exposure of estrogen receptor (ER)-positive human breast cancer cells to pharmacological levels of RO 48-8071 reduced cell viability. Administration of RO 48-8071 to mice with BT-474 tumor xenografts prevented tumor growth, with no apparent toxicity.

At the molecular level it was determined that RO 48-8071 degraded the proliferative alpha estrogen receptor (ERalpha) while concomitantly inducing the antiproliferative protein ERbeta. Chemical inhibition or genetic knockdown of ERbeta prevented RO 48-8071-induced loss of cell viability. Importantly, RO 48-8071 had no effect on the viability of normal human mammary cells.

“Cholesterol is a molecule found in all animal cells and serves as a structural component of cell membranes,” said senior author Dr. Salman Hyder, professor of biomedical sciences at the University of Missouri. “Because tumor cells grow rapidly they need to synthesize more cholesterol. Scientists working to cure breast cancer often seek out alternative targets that might slow or stop the progression of the disease, including the elimination of the cancerous cells. In our study, we targeted the production of cholesterol in cancer cells leading to death of breast cancer cells.”

Related Links:

University of Missouri



comments powered by Disqus

Channels

Drug Discovery

view channel
Image: Disruption and removal of malaria parasites by the experimental drug (+)-SJ733 (Photo courtesy of the University of California, San Francisco).

Experimental Antimalaria Drug Induces the Immune System to Destroy Infected Red Blood Cells

An experimental drug for the treatment of malaria was found to induce morphological changes in infected erythrocytes that enabled the immune system to recognize and eliminate them. Investigators at... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Business

view channel

R&D Partnership Initiated to Reduce Development Time for New Drugs

nanoPET Pharma, GmbH (Berlin, Germany) signed an open-ended framework contract with the international pharmaceutical company Boehringer Ingelheim (Ridgefield, CT, USA). By developing customized contrast agents for research in both basic and preclinical studies, nanoPET Pharma will contribute to the enhancement of Boehringer... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.