Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
BioConferenceLive

Metallopolymers Protect Penicillin-Like Antibiotics from Bacterial Beta-Lactamase

By BiotechDaily International staff writers
Posted on 12 May 2014
Image: MRSA (in yellow) is vulnerable to a new polymer-antibiotic combination (Photo courtesy of the [US] National Institute of Allergy and Infectious Diseases).
Image: MRSA (in yellow) is vulnerable to a new polymer-antibiotic combination (Photo courtesy of the [US] National Institute of Allergy and Infectious Diseases).
Novel drug combinations that unite classical penicillin-like antibiotics with metallopolymers effectively kill bacteria, including "superbugs" such as MRSA (methicillin-resistant Staphylococcus aureus) that had developed beta-lactamase enzyme-based resistance to the antibiotics.

Metallopolymers are a class of polymers with metal atoms either in the backbone or at the side chain. These polymers exhibit many unprecedented properties and functions that conventional organic polymers usually lack. Among metallopolymers, metallocene-containing polymers have attracted significant attention due to their unique electrochemical, catalytic, and optical properties. Metallocene-containing polymers are widely used for redox active systems as recognition of ions and sugars and modification of electrodes.

MRSA, a complex of multi-drug-resistant Gram-positive bacterial strains, has proven especially problematic in both hospital and community settings by deactivating conventional beta-lactam antibiotics, including penicillins, cephalosporins, and carbapenems, through various mechanisms, resulting in increased mortality rates and hospitalization costs.

To correct this problem, investigators at the University of South Carolina (Columbia, USA) developed an improved class of beta-lactam antibiotics by conjugating classical penicillin-like antibiotics to cobaltocenium metallopolymers.

They reported in the March 17, 2014, online edition of the Journal of the American Chemical Society that these combinations exhibited a synergistic effect against MRSA by efficiently inhibiting activity of beta-lactamase and effectively lysing bacterial cells. Various conventional beta-lactam antibiotics, including penicillin-G, amoxicillin, ampicillin, and cefazolin, were protected from beta-lactamase hydrolysis via the formation of unique ion-pairs between their carboxylate anions and cationic cobaltocenium moieties.

"Instead of developing new antibiotics, here we ask the question, "Can we recycle the old antibiotics"? With traditional antibiotics like penicillin G, amoxicillin, ampicillin, and so on, can we give them new life"? In the United States every year, around 100,000 patients die of bacteria-induced infections," said senior author Dr. Chuanbing Tang, professor of chemistry and biochemistry at the University of South Carolina. "And the problem is increasing because bacteria are building resistance. It is a really, really big problem, not only for individual patients, but also for society."

Related Links:

University of South Carolina



comments powered by Disqus

Channels

Therapeutics

view channel
Image: This type of electronic pacemaker could become obsolete if induction of biological pacemaker cells by gene therapy proves successful (Photo courtesy of Wikimedia Commons).

Gene Therapy Induces Functional Pacemaker Cells in Pig Heart Failure Model

Cardiovascular disease researchers working with a porcine heart failure model have demonstrated the practicality of using gene therapy to replace implanted electronic pacemakers to regulate heartbeat.... Read more

Lab Technologies

view channel
Image: Neurons (greenish yellow) attach to silk-based scaffold (blue) creating functional networks throughout the scaffold pores (dark areas) (Photo courtesy of Tufts University).

Functional 3D Brain-Like Tissue Model Bioengineered

Researchers recently reported on the development of the first complex, three-dimensional (3D) model comprised of brain-like cortical tissue that displays biochemical and electrophysiologic responses, and... Read more

Business

view channel

Global Computational Biology Sector Expected to Reach over USD 4 Billion by 2020

The global market for computational biology is expected to reach USD 4.285 billion by 2020 growing at a compound annual growth rate (CAGR) of 21.1%, according to new market research. Steady surge in the usage and application of computational biology for bioinformatics R&D programs designed for sequencing genomes... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.