Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC

Grape Seed Extract Increases Effectiveness of Chemotherapy While Alleviating Damaging Side Effects

By BiotechDaily International staff writers
Posted on 25 Feb 2014
Image: Grape seed extract may represent a new therapeutic option to alleviate damage caused by chemotherapy to intestinal tissues while reducing the viability of colon cancer cells (Photo courtesy of Nutritional Outlook).
Image: Grape seed extract may represent a new therapeutic option to alleviate damage caused by chemotherapy to intestinal tissues while reducing the viability of colon cancer cells (Photo courtesy of Nutritional Outlook).
Australian cancer researchers have shown that grape seed extract can alleviate some of the damage caused by chemotherapy for colon cancer while increasing the effectiveness of the treatment.

Grape seed extract is used as a folk or traditional remedy for conditions related to the heart and blood vessels, such as atherosclerosis, high blood pressure, high cholesterol, and poor circulation; complications related to diabetes, such as nerve and eye damage; vision problems, such as macular degeneration; swelling after an injury or surgery; cancer prevention; and wound healing. Previous work with cancer cells found that compounds in grape seed extract created an environment that was unfavorable for cancer cell growth.

Investigators at the University of Adelaide (Australia) worked with commercially available grape seed extract that was composed of tannins extracted from the grape seeds that had been freeze-dried and powdered. The extract was tested in laboratory studies using colon cancer cells grown in culture and in a rat cancer model.

Results published in the January 21, 2014, online edition of the journal PLOS ONE revealed that the grape seed extract increased the growth-inhibitory effects of chemotherapy (5-Fluorouracil) on colon cancer cells in culture by 26%. In the animal model the extract showed no side effects on healthy intestinal tissue at concentrations of up to 1,000 milligrams per kilogram. Co-treatment with the extract decreased chemotherapy-induced inflammation by up to 55% and significantly decreased intestinal damage compared to the chemotherapy control.

"This is the first study showing that grape seed can enhance the potency of one of the major chemotherapy drugs in its action against colon cancer cells," said first author Dr. Amy Cheah, a researcher at the University of Adelaide. "Our research also showed that in laboratory studies grape seed taken orally significantly reduced inflammation and tissue damage caused by chemotherapy in the small intestine, and had no harmful effects on noncancerous cells. Unlike chemotherapy, grape seed appears to selectively act on cancer cells and leave healthy cells almost unaffected."

"Our experimental studies have shown that grape seed extract reduced chemotherapy-induced inflammation and damage and helped protect healthy cells in the gastrointestinal tract," said Dr. Cheah. "While this effect is very promising, we were initially concerned that grape seed could reduce the effectiveness of the chemotherapy. In contrast, we found that grape seed extract not only aided the ability of chemotherapy to kill cancer cells, but was also more potent than the chemotherapy we tested at one concentration."

Related Links:

University of Adelaide



Channels

Genomics/Proteomics

view channel
Image: Transmission electron micrograph of norovirus particles in feces (Photo courtesy of Wikimedia Commons).

Norovirus Interacts with Gut Bacteria to Establish a Persistent Infection That Can Be Blocked by Interferon Lambda

A team of molecular microbiologists and virologists has found that norovirus requires an intimate interaction with certain gut bacteria to establish a persistent infection, and that the infective process... Read more

Biochemistry

view channel

Possible New Target Found for Treating Brain Inflammation

Scientists have identified an enzyme that produces a class of inflammatory lipid molecules in the brain. Abnormally high levels of these molecules appear to cause a rare inherited eurodegenerative disorder, and that disorder now may be treatable if researchers can develop suitable drug candidates that suppress this enzyme.... Read more

Therapeutics

view channel
Image: Cancer cells infected with tumor-targeted oncolytic virus (red). Green indicates alpha-tubulin, a cell skeleton protein. Blue is DNA in the cancer cell nuclei (Photo courtesy of Dr. Rathi Gangeswaran, Bart’s Cancer Institute).

Innovative “Viro-Immunotherapy” Designed to Kill Breast Cancer Cells

A leading scientist has devised a new treatment that employs viruses to kill breast cancer cells. The research could lead to a promising “viro-immunotherapy” for patients with triple-negative breast cancer,... Read more

Lab Technologies

view channel
Image: MIT researchers have designed a microfluidic device that allows them to precisely trap pairs of cells (one red, one green) and observe how they interact over time (Photo courtesy of Burak Dura, MIT).

New Device Designed to See Communication between Immune Cells

The immune system is a complicated network of many different cells working together to defend against invaders. Effectively combating an infection depends on the interactions between these cells.... Read more

Business

view channel

Program Designed to Provide High-Performance Computing Cluster Systems for Bioinformatics Research

Dedicated Computing (Waukesha, WI, USA), a global technology company, reported that it will be participating in the Intel Cluster Ready program to deliver integrated high-performance computing cluster solutions to the life sciences market. Powered by Intel Xeon processors, Dedicated Computing is providing a range of... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.