Features | Partner Sites | Information | LinkXpress
Sign In
PZ HTL SA
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

European-Funded Research Project Seeks Molecular Basis for Chronic Pain

By BiotechDaily International staff writers
Posted on 26 Nov 2013
A consortium of research institutions and medical centers will be participating in a four-year program funded by the European commission that aims at exploring and defining molecular mechanisms underlying chronic pain.

One out of five Europeans suffers from chronic pain, a syndrome that can induce anxiety and depression and greatly impair the quality of life. It has been estimated that treatment of chronic pain costs the European national health systems up 1.5%–3% of their gross domestic product (GDP) each year.

The recently announced six million euro "ncRNAPain" project will be a cooperative effort of 11 universities, medical centers, and research institutes in seven countries (Austria, the Czech Republic, Denmark, France, Germany, Israel, and the United Kingdom.

The researchers, including those at the Hebrew University of Jerusalem (Israel), will focus on pain-regulating noncoding ribonucleic acids (ncRNAs). They will be seeking to identify and validate specific ncRNAs that could serve as basis for the development of new drugs for pain prevention and relief.

Dr. Hermona Soreq, professor of molecular neuroscience at The Hebrew University of Jerusalem, said, “MicroRNAs (a form of ncRNAs) are a new finding. They are only known for less than 20 years, but it is already clear that they have an important surveillance job, controlling many genes. They do that by wrapping around gene products, the RNA, and reducing their option to get translated into proteins. Furthermore, they block an entire series of genes, all involved in a pathway, so they work like general dimmers of electricity, so to speak, not blackening out but shadowing. We know about many hundreds of microRNAs, and a large part of those are unique to humans (so mouse tests will not be useful).”

“The new group is about microRNAs involved in pain—an important phenomenon which is often regarded as a symptom, whereas it should be taken more seriously as a phenomenon on its own merit and treated as such. This is especially the case in advanced ages, which also implies that its impact will increase with life expectancy prolongation,” said Dr. Soreq. “What we want to do is to combine sequencing tests in human blood cells with efforts to block excess microRNAs. There are many partners involved, including pain clinician specialists, but also basic researchers. We hope to gain new diagnostic biomarkers and find new targets for therapeutic interference.”

Related Links:

The Hebrew University of Jerusalem



Channels

Genomics/Proteomics

view channel
Image: Biopsy of small bowel showing celiac disease manifested by blunting of villi, crypt hyperplasia, and lymphocyte infiltration of crypts (Photo courtesy of Wikimedia Commons).

Reduced Elafin Levels Associated with Celiac Disease Bowel Inflammation

Levels of the enzyme elafin, an endogenous serine protease inhibitor, were lower in the small intestinal epithelium of patients with active celiac disease (CD) as compared to similar tissue from control patients.... Read more

Biochemistry

view channel

Mitochondrial Cause of Aging Can Be Reversed

Researchers have found a cause of aging in lab animals that can be reversed, possibly providing an avenue for new treatments for age-related diseases including type 2 diabetes, cancer, muscle wasting, and inflammatory diseases. The researchers plan to begin human trials late 2014. The study, which was published December... Read more

Therapeutics

view channel

Cytokine Identified That Causes Mucositis in Cancer Therapy Patients

The action of the cytokine interleukin 1-beta (IL-1beta) has been found to underlie the onset of mucositis, a common, severe side effect of chemotherapy and irradiation of cancer patients. Mucositis occurs as a result of cell death in reaction to chemo- or radiotherapy. The mucosal lining of the mouth becomes thin, may... Read more

Business

view channel

Analytical Sciences Trade Fair Declared a Rousing Success

Organizers of this year's 24th "analytica" biosciences trade fair have reported significant increases in both the number of visitors and exhibitors compared to the 2012 event. The analytica trade fair for laboratory technology, analysis, and biotechnology has been held at the Munich (Germany) Trade Fair Center every... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.