Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC

Vegetable Compound Found to Protect Against Radiation

By BiotechDaily International staff writers
Posted on 28 Oct 2013
Researchers have reported that a compound found in cruciferous vegetable such as cauliflower, cabbage, and broccoli shields rats and mice from lethal doses of radiation.

Their study, published October 15, 2013, in the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS) suggests the compound, already demonstrated to be safe for humans, may protect healthy tissues during radiotherapy for cancer treatment and prevent or lessen sickness caused by radiation exposure.

The compound, known as DIM (3,3'-diindolylmethane), previously has been found to have cancer preventive properties. “DIM has been studied as a cancer prevention agent for years, but this is the first indication that DIM can also act as a radiation protector,” stated the study’s corresponding author, Eliot Rosen, MD, PhD, of Georgetown University Lombardi Comprehensive Cancer Center (Washington DC, USA).

The scientists irradiated rats in the study with lethal doses of gamma ray radiation. The animals were then treated with a daily injection of DIM for two weeks, starting 10 minutes after the radiation exposure. The result was amazing, according to Dr. Rosen, a professor of oncology, biochemistry, cell and molecular biology, and radiation medicine. “All of the untreated rats died, but well over half of the DIM-treated animals remained alive 30 days after the radiation exposure.”

Dr. Rosen added that DIM also provided protection whether the first injection was administered 24 hours before or up to 24 hours after radiation exposure. “We also showed that DIM protects the survival of lethally irradiated mice,” Dr. Rosen said. Furthermore, irradiated mice treated with DIM had less reduction in red blood cells, white blood cells and platelets—side effects often seen in patients undergoing radiation treatment for cancer.

Dr. Rosen noted that this study revealed two potential uses of the compound. “DIM could protect normal tissues in patients receiving radiation therapy for cancer, but could also protect individuals from the lethal consequences of a nuclear disaster.”

Rosen and study coauthors Saijun Fan, PhD, and Milton Brown, MD, PhD, are co-inventors on a patent application that has been filed by Georgetown University for the use of DIM and DIM-related compounds as radioprotectors.

Related Links:
Georgetown University Lombardi Comprehensive Cancer Center



Channels

Genomics/Proteomics

view channel
Image: Transmission electron micrograph of norovirus particles in feces (Photo courtesy of Wikimedia Commons).

Norovirus Interacts with Gut Bacteria to Establish a Persistent Infection That Can Be Blocked by Interferon Lambda

A team of molecular microbiologists and virologists has found that norovirus requires an intimate interaction with certain gut bacteria to establish a persistent infection, and that the infective process... Read more

Drug Discovery

view channel

Curcumin Used to Treat Alzheimer’s Disease

Curcumin, a natural substance found in the spice turmeric, has been used by many Asian cultures for centuries. Now, new research suggests that a close chemical analog of curcumin has properties that may make it useful as a treatment for Alzheimer’s disease. “Curcumin has demonstrated ability to enter the brain, bind... Read more

Biochemistry

view channel
Image: Induced pluripotent stem (iPS) cells, which act very much like embryonic stem cells, are shown growing into heart cells (blue) and nerve cells (green) (Photo courtesy of Gladstone Institutes/Chris Goodfellow).

Methodology Devised to Improve Stem Cell Reprogramming

In a study that provides scientists with a critical new determination of stem cell development and its role in disease, researchers have established a first-of-its-kind approach that outlines the stages... Read more

Therapeutics

view channel
Image: Cancer cells infected with tumor-targeted oncolytic virus (red). Green indicates alpha-tubulin, a cell skeleton protein. Blue is DNA in the cancer cell nuclei (Photo courtesy of Dr. Rathi Gangeswaran, Bart’s Cancer Institute).

Innovative “Viro-Immunotherapy” Designed to Kill Breast Cancer Cells

A leading scientist has devised a new treatment that employs viruses to kill breast cancer cells. The research could lead to a promising “viro-immunotherapy” for patients with triple-negative breast cancer,... Read more

Lab Technologies

view channel
Image: MIT researchers have designed a microfluidic device that allows them to precisely trap pairs of cells (one red, one green) and observe how they interact over time (Photo courtesy of Burak Dura, MIT).

New Device Designed to See Communication between Immune Cells

The immune system is a complicated network of many different cells working together to defend against invaders. Effectively combating an infection depends on the interactions between these cells.... Read more

Business

view channel

Program Designed to Provide High-Performance Computing Cluster Systems for Bioinformatics Research

Dedicated Computing (Waukesha, WI, USA), a global technology company, reported that it will be participating in the Intel Cluster Ready program to deliver integrated high-performance computing cluster solutions to the life sciences market. Powered by Intel Xeon processors, Dedicated Computing is providing a range of... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.