Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

10 May 2016 - 16 May 2016
11 May 2016 - 13 May 2016

Positively Charged Anticancer Nanoparticles Accumulate in the Acidic Microenvironment of a Tumor

By BiotechDaily International staff writers
Posted on 24 Jul 2013
Print article
Nanoparticles containing an anticancer drug within a weak polybase sphere accumulate inside tumors where the acidic environment promotes their retention and induces swelling, which enhances delivery of the chemotherapeutic load.

Investigators at Purdue University (West Lafayette, IN, USA) coined the term "pH phoresis" to describe the tendency of nanoparticles composed of weak polybases (such as polyamines) to migrate to areas of negative charge when exposed to a pH gradient.

Furthermore, in regions of lower pH—such as in the pH 6.5-6.9 microenvironment surrounding a tumor—increased protonation of the amines in the shell cause them to repel each other, which forces the particles to expand in size. Doubling the size of the particles would, in theory, result in a similar increase in the efficiency of drug delivery to tumors.

"This phenomenon, which we term pH phoresis, may provide a useful mechanism for improving the delivery of drugs to cancer cells in solid tumor tissues," said first author Dr. You-Yeon Won, associate professor of chemical engineering at Purdue University. "Such an effect would be a game changer by delivering the proper dose of anticancer drugs inside tumor cells. This pH phoresis concept also could be combined readily within other established drug-delivery methodologies, making it potentially practical for medical application."

Related Links:
Purdue University




Print article

Channels

Genomics/Proteomics

view channel
Image: A confocal microscopy image of human fibroblasts derived from embryonic stem cells. The nuclei appear in blue, while smaller and more numerous mitochondria appear in red (Photo courtesy of Dr. Shoukhrat Mitalipov, Oregon Health & Science University).

Stem Cells Derived from Older Individuals May Carry Unsafe Mitochondrial DNA Mutations

Induced pluripotent stem cells (iPSCs) derived from the skin fibroblasts of older individuals have a likelihood of harboring mitochondrial DNA mutations, which may render them unfit for clinical applications.... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Lab Technologies

view channel

Huge Modifiable Biomedical Database to Be Available on the Wikidata Site

Genome researchers are exploiting the power of the open Internet community Wikipedia database to create a comprehensive resource for geneticists, molecular biologists, and other interested life scientists. While efficiency in generating scientific data improves almost daily, applying meaningful relationships between... Read more

Business

view channel

DNA Synthesis Specialists Acquire Advanced Software Design Capabilities

An American biotech firm that develops and produces synthetic DNA has established an international presence by purchasing an Israeli genetic design software company. Twist Bioscience Corporation (San Francisco, CA, USA), a company specializing in rapid, high-quality DNA synthesis, announced that Genome Compiler Corporation... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.