Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Positively Charged Anticancer Nanoparticles Accumulate in the Acidic Microenvironment of a Tumor

By BiotechDaily International staff writers
Posted on 24 Jul 2013
Print article
Nanoparticles containing an anticancer drug within a weak polybase sphere accumulate inside tumors where the acidic environment promotes their retention and induces swelling, which enhances delivery of the chemotherapeutic load.

Investigators at Purdue University (West Lafayette, IN, USA) coined the term "pH phoresis" to describe the tendency of nanoparticles composed of weak polybases (such as polyamines) to migrate to areas of negative charge when exposed to a pH gradient.

Furthermore, in regions of lower pH—such as in the pH 6.5-6.9 microenvironment surrounding a tumor—increased protonation of the amines in the shell cause them to repel each other, which forces the particles to expand in size. Doubling the size of the particles would, in theory, result in a similar increase in the efficiency of drug delivery to tumors.

"This phenomenon, which we term pH phoresis, may provide a useful mechanism for improving the delivery of drugs to cancer cells in solid tumor tissues," said first author Dr. You-Yeon Won, associate professor of chemical engineering at Purdue University. "Such an effect would be a game changer by delivering the proper dose of anticancer drugs inside tumor cells. This pH phoresis concept also could be combined readily within other established drug-delivery methodologies, making it potentially practical for medical application."

Related Links:
Purdue University




Print article

Channels

Business

view channel

Purchase Agreement to Boost Ebola Vaccine Development

A deal to help boost development of a vaccine to protect against Ebolavirus infection was finalized at the recent Davos Conference in Switzerland. Gavi (Geneva, Switzerland), the global alliance for vaccines and immunizations, announced that it would spend five million USD to purchase the Ebola vaccine under development... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.