Features | Partner Sites | Information | LinkXpress
Sign In
PZ HTL SA
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

Antiautoimmune Drug Treatment Combined with Bone Marrow Transplant Cures Mouse Model of Type I Diabetes

By BiotechDaily International staff writers
Posted on 12 Jun 2013
Treatment with a drug to block autoimmune attack combined with transplantation of adult bone marrow cells or purified bone marrow progenitor cells restored the population of insulin-producing pancreatic beta cells and cured a mouse model of type I diabetes.

Investigators at the University of Missouri (Columbia, USA) had previously shown that a peptide drug (Ig-GAD2 ) comprising a 14 amino acid sequence isolated from the enzyme glutamic acid decarboxylase, induced immune modulation in hyperglycemic mice that was able to control pancreatic inflammation, stimulate beta-cell regeneration, and prevent type I diabetes progression. However, this treatment was unable to reverse the course of the disease despite eradication of inflammatory immune cells from the pancreas.

In a paper published in the May 28, 2013, online edition of the journal Diabetes the investigators reported that the reason for this failure was linked to damage done by autoimmune attack to the capillaries that supply blood to the pancreas. To repair this damage they injected diabetic rats with either bone marrow cells or purified bone marrow progenitor cells in combination with Ig-GAD2.

The investigators reported that when the mice received bone marrow cells together with Ig-GAD2, in addition to immune modulation there was concomitant formation of new beta- and endothelial cells in the pancreas. The new beta cells were of host origin while the donor bone marrow cells gave rise to the endothelial cells. On the other hand, transfer of purified bone marrow endothelial progenitors instead of whole bone marrow cells sustained both beta- and endothelial cell formation and reversal of diabetes.

Related Links:
University of Missouri




Channels

Genomics/Proteomics

view channel
Image: Biopsy of small bowel showing celiac disease manifested by blunting of villi, crypt hyperplasia, and lymphocyte infiltration of crypts (Photo courtesy of Wikimedia Commons).

Reduced Elafin Levels Associated with Celiac Disease Bowel Inflammation

Levels of the enzyme elafin, an endogenous serine protease inhibitor, were lower in the small intestinal epithelium of patients with active celiac disease (CD) as compared to similar tissue from control patients.... Read more

Biochemistry

view channel

Mitochondrial Cause of Aging Can Be Reversed

Researchers have found a cause of aging in lab animals that can be reversed, possibly providing an avenue for new treatments for age-related diseases including type 2 diabetes, cancer, muscle wasting, and inflammatory diseases. The researchers plan to begin human trials late 2014. The study, which was published December... Read more

Therapeutics

view channel

Cytokine Identified That Causes Mucositis in Cancer Therapy Patients

The action of the cytokine interleukin 1-beta (IL-1beta) has been found to underlie the onset of mucositis, a common, severe side effect of chemotherapy and irradiation of cancer patients. Mucositis occurs as a result of cell death in reaction to chemo- or radiotherapy. The mucosal lining of the mouth becomes thin, may... Read more

Business

view channel

Analytical Sciences Trade Fair Declared a Rousing Success

Organizers of this year's 24th "analytica" biosciences trade fair have reported significant increases in both the number of visitors and exhibitors compared to the 2012 event. The analytica trade fair for laboratory technology, analysis, and biotechnology has been held at the Munich (Germany) Trade Fair Center every... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.