Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA

Antiautoimmune Drug Treatment Combined with Bone Marrow Transplant Cures Mouse Model of Type I Diabetes

By BiotechDaily International staff writers
Posted on 12 Jun 2013
Treatment with a drug to block autoimmune attack combined with transplantation of adult bone marrow cells or purified bone marrow progenitor cells restored the population of insulin-producing pancreatic beta cells and cured a mouse model of type I diabetes.

Investigators at the University of Missouri (Columbia, USA) had previously shown that a peptide drug (Ig-GAD2 ) comprising a 14 amino acid sequence isolated from the enzyme glutamic acid decarboxylase, induced immune modulation in hyperglycemic mice that was able to control pancreatic inflammation, stimulate beta-cell regeneration, and prevent type I diabetes progression. However, this treatment was unable to reverse the course of the disease despite eradication of inflammatory immune cells from the pancreas.

In a paper published in the May 28, 2013, online edition of the journal Diabetes the investigators reported that the reason for this failure was linked to damage done by autoimmune attack to the capillaries that supply blood to the pancreas. To repair this damage they injected diabetic rats with either bone marrow cells or purified bone marrow progenitor cells in combination with Ig-GAD2.

The investigators reported that when the mice received bone marrow cells together with Ig-GAD2, in addition to immune modulation there was concomitant formation of new beta- and endothelial cells in the pancreas. The new beta cells were of host origin while the donor bone marrow cells gave rise to the endothelial cells. On the other hand, transfer of purified bone marrow endothelial progenitors instead of whole bone marrow cells sustained both beta- and endothelial cell formation and reversal of diabetes.

Related Links:
University of Missouri




Channels

Genomics/Proteomics

view channel
Image: Pulsed near infrared light (shown in red) is shone onto a tumor (shown in white) that is encased in blood vessels. The tumor is imaged by photoacoustic tomography via the ultrasound emission (shown in blue) from the gold nanotubes (Photo courtesy of Jing Claussen (iThera Medical, Germany)).

Gold Nanotubes Are Novel Agents for Cancer Diagnosis and Treatment

Cancer researchers have produced a highly defined class of gold nanotubes that are suitable for use in animals as in vivo imaging nanoprobes, photothermal conversion agents, and drug delivery vehicles.... Read more

Biochemistry

view channel

Possible New Target Found for Treating Brain Inflammation

Scientists have identified an enzyme that produces a class of inflammatory lipid molecules in the brain. Abnormally high levels of these molecules appear to cause a rare inherited eurodegenerative disorder, and that disorder now may be treatable if researchers can develop suitable drug candidates that suppress this enzyme.... Read more

Lab Technologies

view channel
Image: The FLUOVIEW FVMPE-RS Gantry microscope (Photo courtesy of Olympus).

New Multiphoton Laser Scanning Microscope Configurations Expand Research Potential

Two new configurations of a state-of-the-art multiphoton laser scanning microscope extend the usefulness of the instrument for examining rapidly occurring biological events and for obtaining images from... Read more

Business

view channel

Roche Acquires Signature Diagnostics to Advance Translational Research

Roche (Basel, Switzerland) will advance translational research for next generation sequencing (NGS) diagnostics by leveraging the unique expertise of Signature Diagnostics AG (Potsdam, Germany) in biobanks and development of novel NGS diagnostic assays. Signature Diagnostics is a privately held translational oncology... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.