Features | Partner Sites | Information | LinkXpress
Sign In
JIB
BioConferenceLive
GLOBETECH PUBLISHING

Biodegradable Nanoparticles Maintain Glucose Balance in Mouse Diabetes Model

By BiotechDaily International staff writers
Posted on 30 May 2013
Image: Senior author Dr. Daniel G. Anderson (Photo courtesy of Massachusetts Institute of Technology).
Image: Senior author Dr. Daniel G. Anderson (Photo courtesy of Massachusetts Institute of Technology).
Diabetes researchers have developed an acid-degradable polymeric "nanonetwork" made up of nanoparticles loaded with insulin that can detect elevated glucose levels in the blood of diabetics and then release the hormone to return glucose levels to normal.

Investigators at the Massachusetts Institute of Technology (Cambridge, USA) adapted nanotechnology techniques that they had developed for anticancer drug delivery to address the problem of maintaining the glucose balance in diabetes patients.

They prepared a gel-like structure containing a mixture of oppositely charged nanoparticles that by attracting each other could maintain the integrity of the gel and prevent individual nanoparticles from becoming detached. Each nanoparticle was a dextran sphere containing insulin and an enzyme capable of converting glucose to gluconic acid. The structure of the dextran sphere allowed glucose to diffuse freely, so when sugar levels in the blood were elevated, the enzyme produced large quantities of gluconic acid, lowering the pH of the local environment. The acidic environment caused the dextran spheres to disintegrate, releasing insulin into the bloodstream.

The nanoparticle gel was tested in a Type I diabetes mouse model. Results published in the May 2, 2013, online edition of the journal ACS Nano revealed that a single subcutaneous injection of the gel corrected glucose imbalance and maintained normal blood-sugar levels in the animals for an average of 10 days. As the particles were mostly composed of polysaccharides, they were biocompatible and eventually degraded in the body.

“Insulin really works, but the problem is people do not always get the right amount of it. With this system of extended release, the amount of drug secreted is proportional to the needs of the body,” said senior author Dr. Daniel Anderson, associate professor of chemical engineering at the Massachusetts Institute of Technology.

Related Links:

Massachusetts Institute of Technology



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: Microcomputed tomography images (top) and histology images (bottom) of the knees of mice fed a very high fat diet containing omega-3 fatty acid supplement (left) or only omega-6 fatty acids (right) after a knee injury. The omega-6 diet showed abnormal bone remodeling and calcified tissue formation in the joint (white arrow). The omega-6 diet also showed significant loss of cartilage (red staining, yellow arrowhead) and increased joint inflammation (Photo courtesy of Duke University).

Dietary Omega-3 Fatty Acids Moderate Severity of Osteoarthritis in a Mouse Model

Researchers working with an osteoarthritis (OA) obese mouse model found that the fat content of the animals' diet contributed more to the development or arrest of OA than did body weight.... Read more

Therapeutics

view channel

Vaccine Being Developed for Heart Disease Close to Reality

The world’s first vaccine for heart disease is becoming a possibility with researchers demonstrating significant arterial plaque reduction in concept testing in mice. Klaus Ley, MD, from the La Jolla Institute for Allergy and Immunology (LA Jolla, CA, USA), and a vascular immunology specialist, is leading the vaccine... Read more

Business

view channel

A Surge in IPOs Revitalize Investments for the Global Pharma and Biotech

Anti-infective drugs, oncology, and pharmaceutical contract laboratories attract the most investment up to now. The intensified private equity and venture capital (PEVC) deal activity in the global healthcare industry during the recession years, 2008–2010, witnessed a waning post-2010. However, the decline in deals... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.