Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
PZ HTL SA

Liposomes Expand Cancer Drug's Bioavailability and Potency in Mouse Model

By BiotechDaily International staff writers
Posted on 16 May 2013
Image: First author Dr. Carey Anders (Photo courtesy of the University of North Carolina, Lineberger Comprehensive Cancer Center).
Image: First author Dr. Carey Anders (Photo courtesy of the University of North Carolina, Lineberger Comprehensive Cancer Center).
Encapsulation of the anticancer drug doxorubicin (doxo) within PEGylated liposomes increased the compound's intracranial tumor bioavailability, extended its lifetime in circulation, and improved the survival rate of mice bearing intercranial triple negative breast tumors.

Investigators at the University of North Carolina (Chapel Hill, USA) sought to decrease the toxicity of doxo and increase the length of time it could circulate in the blood by enclosing the drug within PEGylated liposomes.

The investigators inoculated athymic mice intracerebrally with triple negative breast cancer cells that expressed the enzyme luciferase. They then treated some of the animals with doxo ecapslulated in PEGylated liposomes (PLD) or with free doxo (NonL-doxo). Efficacy of the treatment was assessed by survival of the animals and detection of bioluminescence.

Results published in the May 1, 2013, issue of the journal PLOS ONE revealed that treatment with PLD resulted in a 1,500-fold higher plasma and 20-fold higher intracranial tumor bioavailability compared with NonL-doxo. In addition, PLD was detected in plasma and intracranial tumors 96 hours following treatment compared to the drug being undetectable in plasma and tumors after 24 hours in the NonL-doxo animals. Survival rates for the PLD treated mice were significantly prolonged as compared NonL-doxo.

Related Links:

University of North Carolina


comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: This novel, flexible film that can react to light is a promising step toward an artificial retina (Photo courtesy of the American Chemical Society).

Novel Nanofilm May Be Artificial Retina Precursor

Researchers have used advanced nanotechnology techniques to develop a light-sensitive film that has potential for future artificial retina applications. Investigators at the Hebrew University of Jerusalem... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Business

view channel

R&D Partnership Initiated to Reduce Development Time for New Drugs

nanoPET Pharma, GmbH (Berlin, Germany) signed an open-ended framework contract with the international pharmaceutical company Boehringer Ingelheim (Ridgefield, CT, USA). By developing customized contrast agents for research in both basic and preclinical studies, nanoPET Pharma will contribute to the enhancement of Boehringer... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.