Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Events

10 May 2016 - 16 May 2016
11 May 2016 - 13 May 2016

Stabilized Nanosponge Particles Sequester and Neutralize Toxins in the Bloodstream

By BiotechDaily International staff writers
Posted on 23 Apr 2013
Print article
Image: Nanosponge Cross Section. Engineers at the University of California, San Diego have invented a "nanosponge" capable of safely removing a broad class of dangerous toxins from the bloodstream, including toxins produced by MRSA (methicillin-resistant Staphylococcus aureus), E Coli, poisonous snakes, and bees. The nanosponges are made of a biocompatible polymer core wrapped in a natural red blood cell membrane (Photo courtesy of Zhang Research Lab, UC San Diego Jacobs School of Engineering).
Image: Nanosponge Cross Section. Engineers at the University of California, San Diego have invented a "nanosponge" capable of safely removing a broad class of dangerous toxins from the bloodstream, including toxins produced by MRSA (methicillin-resistant Staphylococcus aureus), E Coli, poisonous snakes, and bees. The nanosponges are made of a biocompatible polymer core wrapped in a natural red blood cell membrane (Photo courtesy of Zhang Research Lab, UC San Diego Jacobs School of Engineering).
Image: Nanosponge TEM (Transmission electron microscopy) image demonstrated that the nanosponges are approximately 85 nanometers in diameter (Photo courtesy of Zhang Research Lab, UC San Diego Jacobs School of Engineering).
Image: Nanosponge TEM (Transmission electron microscopy) image demonstrated that the nanosponges are approximately 85 nanometers in diameter (Photo courtesy of Zhang Research Lab, UC San Diego Jacobs School of Engineering).
Novel "nanosponges" comprising a biocompatible nanoparticle core coated with fragments of natural red blood cell membranes are able to absorb and neutralize a wide range of pore-forming toxins.

Investigators at the University of California, San Diego (UCSD; USA) had previously used the 85-nanometer diameter nanosponges to deliver chemotherapeutic drugs directly to tumors. The red blood cell membrane coating rendered the nanoparticles invisible to immune system response.

In the current study nanosponges were used to sequester and neutralize toxins circulating in the bloodstream of a mouse model. Results published in the April 14, 2013, online edition of the journal Nature Nanotechnology revealed that preinoculation with nanosponges enabled survival of 89% of mice challenged with a lethal dose of MRSA alpha-hemolysin toxin. Treatment with nanosponges after administration of the lethal dose of toxin resulted in 44% survival. Administering nanosponges and alpha-hemolysin toxin simultaneously at a toxin-to-nanosponge ratio of 70:1 neutralized the toxin and caused no discernible harm to the animals.

In these experiments, the nanosponges were found to have a half-life of 40 hours in the blood circulation of the mice. Eventually the animals' livers metabolized both the nanosponges and the sequestered toxins, with the liver suffering no apparent damage.

"This is a new way to remove toxins from the bloodstream," said senior author Dr. Liangfang Zhang, professor of nanoengineering at UCSD. "Instead of creating specific treatments for individual toxins, we are developing a platform that can neutralize toxins caused by a wide range of pathogens, including MRSA and other antibiotic resistant bacteria."

Related Links:
University of California, San Diego



Print article

Channels

Genomics/Proteomics

view channel
Image: A confocal microscopy image of human fibroblasts derived from embryonic stem cells. The nuclei appear in blue, while smaller and more numerous mitochondria appear in red (Photo courtesy of Dr. Shoukhrat Mitalipov, Oregon Health & Science University).

Stem Cells Derived from Older Individuals May Carry Unsafe Mitochondrial DNA Mutations

Induced pluripotent stem cells (iPSCs) derived from the skin fibroblasts of older individuals have a likelihood of harboring mitochondrial DNA mutations, which may render them unfit for clinical applications.... Read more

Biochemistry

view channel
Image: A space-filling model of the anticonvulsant drug carbamazepine (Photo courtesy of Wikimedia Commons).

Wastewater May Contaminate Crops with Potentially Dangerous Pharmaceuticals

Reclaimed wastewater used to irrigate crops is contaminated with pharmaceutical residues that can be detected in the urine of those who consumed such produce. Investigators at the Hebrew University... Read more

Lab Technologies

view channel

Huge Modifiable Biomedical Database to Be Available on the Wikidata Site

Genome researchers are exploiting the power of the open Internet community Wikipedia database to create a comprehensive resource for geneticists, molecular biologists, and other interested life scientists. While efficiency in generating scientific data improves almost daily, applying meaningful relationships between... Read more

Business

view channel

DNA Synthesis Specialists Acquire Advanced Software Design Capabilities

An American biotech firm that develops and produces synthetic DNA has established an international presence by purchasing an Israeli genetic design software company. Twist Bioscience Corporation (San Francisco, CA, USA), a company specializing in rapid, high-quality DNA synthesis, announced that Genome Compiler Corporation... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.