Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC

Omega-3 Fatty Acid Derivative Slows Tumor Growth by Blocking Formation of New Blood Vessels

By BiotechDaily International staff writers
Posted on 18 Apr 2013
A metabolite derived from an omega-3 fatty acid slows tumor growth by blocking the development of new blood vessels (angiogenesis).

Investigators at the University of California, Davis (USA) worked with cancer cell cultures and mouse cancer models to examine the effects of omega-3 and omega-6 fatty acids on tumor growth.

They reported in the April 3, 2013, online edition of the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS) that epoxy docosapentaenoic acid (EDP), a compound produced by the human body from the fish oil omega-3 fatty acid docosahexaenoic acid (DHA), inhibited primary tumor growth and metastasis by up to nearly 70%. The blocking of tumor growth was shown in a mouse cancer model to be due to EDP-mediated inhibition of vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2)-induced angiogenesis. In cancer cell cultures, EDP also suppressed the endothelial cell migration needed for new blood vessels.

In contrast, epoxyeicosatrienoic acids (EETs), metabolites of the omega-6 fatty acid arachidonic acid (ARA), slightly increased angiogenesis and tumor progression in mice.

“EDP works by a different mechanism than many current anticancer drugs that block angiogenesis,” said first author Dr. Guodong Zhang, a postdoctoral cancer researcher at the University of California, Davis. “Our investigation opens up a new understanding of the pathways by which omega-3 fatty acids exert their biologic effects. As far as we know, EDPs are the first signaling lipids that have been discovered to have such potent anticancer effects. Researchers may be able to use EDPs as structural targets to develop stable analogs as anticancer agents.”

Related Links:
University of California, Davis



Channels

Drug Discovery

view channel
Image: Star-like glial cells in red surround alpha-beta plaques in the cortex of a mouse with a model of Alzheimer\'s disease (Photo courtesy of Strittmatter laboratory/Yale University).

Experimental Cancer Drug Reverses Symptoms in Mouse Model of Alzheimer's Disease

An experimental, but clinically disappointing drug for treatment of cancer has been found to be extremely effective in reversing the symptoms of Alzheimer's disease (AD) in a mouse model.... Read more

Biochemistry

view channel
Image:  Model depiction of a novel cellular mechanism by which regulation of cryptochromes Cry1 and Cry2 enables coordination of a protective transcriptional response to DNA damage caused by genotoxic stress (Photo courtesy of the journal eLife, March 2015, Papp SJ, Huber AL, et al.).

Two Proteins Critical for Circadian Cycles Protect Cells from Mutations

Scientists have discovered that two proteins critical for maintaining healthy day-night cycles also have an unexpected role in DNA repair and protecting cells against genetic mutations that could lead... Read more

Business

view channel

NanoString and MD Anderson Collaborate on Development of Novel Multi-Omic Expression Profiling Assays for Cancer

The University of Texas MD Anderson Cancer Center (Houston, TX, USA) and NanoString Technologies, Inc. (Seattle, WA, USA) will partner on development of a revolutionary new type of assay—simultaneously profiling gene and protein expression, initially aiming to discover and validate biomarker signatures for immuno-oncology... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.