Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC
PZ HTL SA

Compound Enhances Skeletal Tissue Regeneration

By BiotechDaily International staff writers
Posted on 08 Apr 2013
New cutting-edge research revealed how a novel low-molecular-weight compound enhances ectopic bone formation and fracture repair.

The study, by investigators from conducted by the Atlanta Veterans Affairs Medical Center (GA, USA) and Emory University School of Medicine (Atlanta, GA, USA), was conducted to design and evaluate small molecules that could enhance recombinant human bone morphogenetic protein-2 (rhBMP-2) responsiveness. The investigation used two models to assess the ability of a small synthetic molecule to optimize bone formation in a rodent ectopic model and to determine whether an injection of that molecule accelerate callus formation in a rodent femoral fracture model.

The findings revealed that a single dose of the small molecule enhanced bone healing in the ectopic model combined with the occurrence of low-dose exogenous rhBMP-2, and in the femoral fracture model with the presence of only naturally occurring BMPs. The study’s findings, published in March 6, 2013, in the Journal of Bone and Joint Surgery.

SkelRegen, LLC (West Chester, PA, USA) is the first company to focus on newly identified small molecules that target different aspects of the skeletal tissue formation pathway. The study’s findings serves as additional confirmation that by following established procedures, SkelRegen continues to work on research to regenerate bone from scratch. “While our work on skeletal tissue regeneration is far from complete, this study exemplifies that research is continuing and SkelRegen technology is at the forefront,” said Stephen LaNeve, SkelRegen’s cofounder and CEO. “Our partnership with Emory University makes it possible for us to be part of such revolutionary work.”

Boden, SkelRegen’s cofounder and chief medical, science and technology officer, said, “The process was long and arduous and would not have been possible without the computational design work of the Emory/VA team led by Sree Sangadala, PhD But, ultimately these results further demonstrate how bone regeneration with small molecules will transform musculoskeletal care.”

SkelRegen identified not one, but multiple small molecules that are osteoinductive and target different features of the skeletal tissue formation pathway. All of the compounds are inexpensive to manufacture and many of the compounds are clear for other uses by the US Food and Drug Administration (FDA), therefore, they already have acceptable safety and toxicity profiles.

Related Links:

Atlanta Veterans Affairs Medical Center
Emory University School of Medicine
Regen



BIOSIGMA S.R.L.
RANDOX LABORATORIES
SLAS - Society for Laboratory Automation and Screening
comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: The Human Protein Atlas is tissue-based map of the human proteome (Photo courtesy of the Human Protein Atlas).

Open Source Tissue-Based Map of the Human Proteome Launched

Constructed with 13 million annotated images, an interactive database has been created to show the distribution of proteins in all major tissues and organs of the human body. Ten years after the completion... Read more

Biochemistry

view channel

Blocking Enzyme Switch Turns Off Tumor Growth in T-Cell Acute Lymphoblastic Leukemia

Researchers recently reported that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated 25% of the 500 US adolescents and young adults diagnosed yearly with this aggressive disease fail to respond to... Read more

Lab Technologies

view channel

e-Incubator Technology Provides Real-Time Imaging of Bioengineered Tissues in a Controlled Unit

A new e-incubator, an innovative miniature incubator that is compatible with magnetic resonance imaging (MRI), enables scientists to grow tissue-engineered constructs under a controlled setting and to study their growth and development in real time without risk of contamination or damage. Offering the potential to test... Read more

Business

view channel

Two Industry Partnerships Initiated to Fuel Neuroscience Research

Faster, more complex neural research is now attainable by combining technology from two research companies. Blackrock Microsystems, LLC (Salt Lake City, UT, USA), a developer of neuroscience research equipment, announced partnerships with two neuroscience research firms—PhenoSys, GmbH (Berlin, Germany) and NAN Instruments, Ltd.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.