Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

Low-Toxicity Anticancer Agent Proves Effective Against a Variety of Cancers

By BiotechDaily International staff writers
Posted on 08 Apr 2013
Researchers have discovered that the small chemical molecule FL118, a new formulation of a promising anticancer agent, is even more effective in controlling two kinds of cancer than an older version of the compound proved to be six months earlier. Further findings also suggest that the agent may successfully treat other solid tumors as well.

In their earlier research, a team led by Fengzhi Li, PhD, associate professor of oncology in Roswell Park Cancer Institute’s (RPCI; Buffalo, NY, USA) department of pharmacology and therapeutics, demonstrated that FL118 eliminated human colon and head-and-neck tumors in animal models without relapse but was limited in that it could be delivered only by intraperitoneal (IP) administration. This new study, to be published in the April 8, 2013, issue of the American Journal of Translational Research, compares the earlier formulation of the agent to a new version that can also be administered intravenously, adapting it to a much wider potential clinical application.

Comparing the antitumor effectiveness and therapeutic index, or relative toxicity, of FL118 in its new intravenous (IV) formulation with the earlier form, the researchers found that maximum tolerated dose increased three- to seven-fold, depending on dosing regimen. While the original formulation contained Tween 80 or polysorbate 80, a solvent typically included in drug formulations, the agent in its new composition is free of Tween 80, resulting in significantly lower toxicity.

FL118 is a targeted therapy that selectively inhibits the expression of four major cancer-survival gene products: survivin, XIAP, Mcl-1, and/or cIAP2. Whereas both studies assessed the compound’s effectiveness against models of head-and-neck and colon tumors, other research from Dr. Li’s lab suggests that mesothelioma, ovarian, and pancreatic cancers, and potentially other solid tumors, may also be good targets for treatment with FL118.

“This work represents a significant move forward,” noted Dr. Li, senior author on the study. “We’re targeting four of the most resilient and pervasive cancer survival mechanisms, and because the findings from preclinical testing have been so striking, we’re anxious to see FL118 tested in the clinical setting.”

The study’s findings were published online April 2, 2013, in the journal PLOS ONE.

Related Links:

Roswell Park Cancer Institute


comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: A leukemia cell coated with antibody is marked for destruction by activated natural killer cells (Photo courtesy of the University of Southern California).

Leukemia Cells Are Killed in Culture by Immune Cells Grown from the Same Patient

Immune system natural killer (NK) cells were isolated from leukemia patients, expanded in culture, and then shown in an in vitro system to attack and destroy cancer cells from the original cell donors.... Read more

Therapeutics

view channel
Image: Liver cells regenerated in mice treated with a new drug (right) compared with a control group (center) after partial liver removal. Healthy liver cells are shown at left (Photo courtesy of Marshall et al, 2014, the Journal of Experimental Medicine).

New Drug Triggers Liver Regeneration After Surgery

Investigators have revealed that an innovative complement inhibitor decreases complement-mediated liver cell death, and actually stimulates postsurgery liver regrowth in mice. Liver cancer often results... Read more

Lab Technologies

view channel

White-Matter Deficits Found in Codeine-Containing Cough Syrup Users

A magnetic resonance imaging (MRI) study of chronic users of codeine-containing cough syrups (CCS) has found deficits in specific regions of brain white matter and linked these changes with increased impulsivity in codeine-containing cough syrup users. These findings were consistent with findings from earlier research of... Read more

Business

view channel

Partnership Established to Decode Bowel Disease

23andMe (Mountain View, CA,USA), a personal genetics company, is collaborating with Pfizer, Inc. (New York, NY, USA), in which the companies will seek to enroll 10,000 people with inflammatory bowel disease (IBD) in a research project designed to explore the genetic factors associated with the onset, progression, severity,... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.