Features Partner Sites Information LinkXpress
Sign In
Demo Company

Yogurt Probiotics Used to Fight Cancer

By BiotechDaily International staff writers
Posted on 04 Apr 2013
Print article
Probiotics, similar to those found in yogurt, which are found to enhance digestive health, are now being considered as a possible weapon to be used in the war against cancer.

This is the focus of investigators from the Cancer Institute of New Jersey (New Brunswick, USA), a Center of Excellence of the University of Medicine and Dentistry of New Jersey (UMDNJ)-Robert Wood Johnson Medical School, who are studying the effectiveness of probiotics as they relate to the outcomes of bone marrow transplant for blood cancer patients.

Some patients with lymphoma, leukemia, and myeloma are treated with an allogeneic bone marrow transplant where the donor is a blood relative or is unrelated but has the same tissue type. Donated cells can generate an immune attack against cancer cells in the patient, but they can also attack normal healthy cells and tissues. This attack, known as graft-versus-host disease (GVHD), is one of the key problems of transplantation and occurs in the gastrointestinal (GI) tract in 25%–40% of patients who undergo the allogeneic procedure.

When the GI tract breaks down, bacteria in the colon can invade the body and cause nasty infections that trigger the immune system. GVHD can then advance to the liver and other organs. Probiotics are known to decrease the growth of specific types of bacteria. Investigators from the Cancer Institute of New Jersey, who have already determined the probiotic Lactobacillus GG is safe in relation to GVHD, are now exploring its effectiveness as part of the PERFECT (Probiotic Enteric Regimen For Easing Complications of Transplant) trial. The research is being led by Roger Strair, MD, PhD, chief of hematologic alignancies/hematopoietic stem cell transplantation at the Cancer Institute of New Jersey.

“By further exploring the effects of probiotics on graft-versus-host-disease, we may be able to identify methods of preventing infection. We are grateful for their support,” noted Dr. Strair, professor of medicine at UMDNJ-Robert Wood Johnson Medical School.

Related Links:
Cancer Institute of New Jersey

Print article



view channel
Image: Left: Green actin fibers create architecture of the cell. Right: With cytochalasin D added, actin fibers disband and reform in the nuclei (Photo courtesy of the University of North Carolina).

Actin in the Nucleus Triggers a Process That Directs Stem Cells to Mature into Bone

A team of cell biologists has discovered why treatment of mesenchymal stem cells (MSCs) with the mycotoxin cytochalasin D directs them to mature into bone cells (osteoblasts) rather than into fat cells... Read more


view channel

Molecular Light Shed on “Dark” Cellular Receptors

Scientists have created a new research tool to help find homes for orphan cell-surface receptors, toward better understanding of cell signaling, developing new therapeutics, and determining causes of drug side-effects. The approach may be broadly useful for discovering interactions of orphan receptors with endogenous, naturally... Read more

Lab Technologies

view channel
Image: The new ambr 15 fermentation micro-bioreactor system was designed to enhance microbial strain screening applications (Photo courtesy of Sartorius Stedim Biotech).

New Bioreactor System Streamlines Strain Screening and Culture

Biotechnology laboratories working with bacterial cultures will benefit from a new automated micro bioreactor system that was designed to enhance microbial strain screening processes. The Sartorius... Read more


view channel

Purchase of Biopharmaceutical Company Will Boost Development of Nitroxyl-Based Cardiovascular Disease Drugs

A major international biopharmaceutical company has announced the acquisition of a private biotech company that specializes in the development of drugs for treatment of cardiovascular disease. Bristol-Myers Squibb Co. (New York, NY, USA) has initiated the process to buy Cardioxyl Pharmaceuticals Inc. (Chapel Hill, NC, USA).... Read more
Copyright © 2000-2015 Globetech Media. All rights reserved.