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10 May 2016 - 16 May 2016
11 May 2016 - 13 May 2016

Drug Discovery

X-ray Crystallography Study May Lead to New Drugs to Block Cancer Metastasis

Cancer researchers expect that the structure of the enzyme P-Rex1 (PIP3-dependent Rac exchanger 1), which was recently established by X-ray crystallography, will lead to development of a new generation of cancer chemotherapeutic agents to block the processes leading to metastasis. More...
28 Apr 2016
Image: Altered caudal fin morphology following paclitaxel injection into larval zebrafish at 2 dpf. (A) Morphological changes (arrows) in the fin fold 1 hour after injection with 10 µM paclitaxel (insets show higher magnification). (B) Fin damage (arrows) 3 hour after paclitaxel injection. (C) Vehicle controls with undamaged fins 4 hour postinjection. (Scale bar, 200 µm.) hpinj = hours postinjection. (Image courtesy of Lisse TS et al, 2016, PNAS.)

Study Identifies Mechanism Underlying a Form of Sensory Nerve Damage

Researchers have discovered a mechanism that underlies induction of peripheral neuropathy (PN) by the chemotherapeutic agent paclitaxel, raising the prospects for developing treatments for this and possibly also for certain other forms of PN. The work may also lead to companion diagnostics to identify patients who would benefit from these new therapies. More...
27 Apr 2016

Genomics Makeup of Colorectal Tumors Predicts Immune Response

A study based on whole-exome sequencing and immune response finds that colorectal cancers (CRCs) heavily bedecked with tumor-related neoantigens are likely to be permeated with disease-fighting white blood cells (WBCs). The discovery helps sharpen research into therapies that make tumors more vulnerable to such an attack and into companion diagnostics. More...
27 Apr 2016
Image: A micrograph of eosinophilic esophagitis (EoE), H&E stain. Characteristic features are present: Abundant eosinophils—criteria vary; one common definition is: > 20 eosinophils/0.24 mm2; Papillae are elongated; papillae reach into the top 1/3 of the epithelial layer; Basal cell hyperplasia; > 3 cells thick or >15% of epithelial thickness; Spongiosis (Photo courtesy of Wikimedia).

Pathway Implicated in Development of Eosinophilic Esophagitis

Scientists have identified a protein whose dysfunction appears to be involved in causing the tissue damage in patients with eosinophilic esophagitis (EoE). The finding may lead to improved pathology analysis, diagnostics, and specific drug therapies for patients. More...
26 Apr 2016

Enzyme-Loaded Magnetic Nanoparticles Suitable for Therapeutic and Industrial Applications

Members of a novel class of nano-sized transport vessels are composed of only two biocompatible components: an enzyme and magnetite nanoparticles. More...
25 Apr 2016

Cholesterol Analogs Block Growth of Tuberculosis Bacteria

Analogs of cholesterol that have been modified by the addition of non- degradable side chains have been shown to inhibit the growth of Mycobacterium tuberculosis, the bacterium that causes tuberculosis (TB).  More...
21 Apr 2016
Image: A cutaway illustration of the nanogel drug delivery system. The small particle can carry multiple drug agents to a specific target, such as the site of a tumor (Photo courtesy of Nicolle Rager Fuller, [US] National Science Foundation).

Novel Nanogel Drug Delivery System to Undergo Preliminary Clinical Trials

A novel nanogel drug delivery system designed to deliver multiple drugs with different chemical properties is to be tested in a first phase of clinical trials.  More...
21 Apr 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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