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Drug Discovery

Image: S-649266 has more robust antibacterial activity than established antibiotics against multidrug-resistant bacteria (Photo courtesy of Shionogi).

Novel Antibiotic Shows Potential for Broad Range of Infections

The emergence of bacterial resistance to known antibacterial agents is becoming a major challenge in treating the infection caused by multi drug resistant bacteria.   More...
23 Sep 2014

Ibuprofen May Restore Immune Function in Older Individuals

New research suggests that macrophages from the lungs of old mice respond differently to infections than those of young mice, and ibuprofen given to the mice reversed these changes.  More...
17 Sep 2014
Image: The five stages of biofilm development: (1) Initial attachment, (2) Irreversible attachment, (3) Maturation I, (4) Maturation II, and (5) Dispersion. Each stage of development in the diagram is paired with a photomicrograph of a developing P. aeruginosa biofilm. All photomicrographs are shown to same scale (Photo courtesy of Wikimedia Commons).

Ionic Liquids Disperse Bacterial Biofilms and Increase Antibiotic Susceptibility

The ionic liquid choline-geranate was shown to effectively eliminate the protective biofilm generated by bacteria such as Salmonella enterica and Pseudomonas aeruginosa and to significantly increase the susceptibility of these microorganisms to antibiotic treatment.  More...
16 Sep 2014

Apolipoprotein A-1 Mimetic Peptide Reverses Pulmonary Hypertension in Rodent Models

A small peptide that mimics the activity of apolipoprotein A-1, the main protein component of the high density lipoproteins, counteracted the effects of oxidized lipids and alleviated symptoms of pulmonary arterial hypertension in a population of laboratory animals.   More...
14 Sep 2014

Synthetic Virus Designed to Enhance Delivery of New Generation of Pharmaceutical Agents

Dutch scientists have effectively developed an artificial virus that may be used for the delivery of a new generation of pharmaceutical agents, consisting of large biomolecules, by packaging them in a natural manner and delivering them to diseased cells.   More...
10 Sep 2014

Mutation Reducing Fatty Acid-Binding Protein Activity Lowers Heart Attack Risk

A team of Finnish cardiovascular disease researchers found that a mutation generating a low-expression variant of fatty acid-binding protein 4, reduced the risk of heart attack and stroke.    More...
08 Sep 2014

New ELISA Kit Measures Drug-Induced DNA Breaks

A gamma H2AX pharmacodynamic assay kit for the study of double strand DNA breaks through the detection of the phosphorylated histone, gamma-H2AX, is now available for drug developers as well as biotech and other life science researchers.  More...
07 Sep 2014


The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
 
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