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Drug Discovery

Image: Researchers have attached two drugs—TRAIL and Dox—onto graphene strips. TRAIL is most effective when delivered to the external membrane of a cancer cell, while Dox is most effective when delivered to the nucleus, so the researchers designed the system to deliver the drugs sequentially, with each drug hitting a cancer cell where it will do the most damage (Photo courtesy of Dr. Zhen Gu, North Carolina State University).

Anticancer Drug Delivery System Utilizes Graphene Strip Transporters

The ongoing search by cancer researchers for targeted drug delivery systems has generated a novel approach that uses graphene strips to transport simultaneously the anticancer agents TRAIL and Dox.  More...
20 Jan 2015

Blueberries Shown to Pack Big Heart Health Benefits

Just one cup of blueberries per day could be the enough to reduce blood pressure and arterial stiffness, both of which are linked with cardiovascular disease.   More...
20 Jan 2015
Image: Disc-shaped microparticles use monocytes to get to their destination (Photo courtesy of the University of California, Santa Barbara).

Novel Drug Delivery System Capitalizes on Monocytes' Ability to Penetrate Areas of Inflammation

A novel experimental drug delivery system is based on disc-shaped polymeric microparticles that are attached to monocytes, white blood cells that possess a unique ability to target and penetrate into sites of inflammation.  More...
18 Jan 2015
Image: Mycobacterium tuberculosis (stained red) in sputum from a human patient (Photo courtesy of the CDC - US Centers for Disease Control and Prevention).

Combining Drugs Reduces Toxicity of Key Anti-Tuberculosis Therapy Option

Combining a potent drug used to treat multidrug-resistant tuberculosis with a calcium-channel blocker significantly reduces the required dosage of the anti-tuberculosis drug, which eliminates most of its toxic side effects.  More...
14 Jan 2015

Experimental Cancer Drug Disrupts Telomerase Function

Cancer researchers have published a detailed study of the potential chemotherapeutic drug 6-thio-2'-deoxyguanosine, a potent inhibitor of the enzyme telomerase.  More...
12 Jan 2015

New Software Uses X-ray Diffraction to Generate 3-D Images of Molecular Machines

Scientists are making it simpler for pharmaceutical companies and researchers to visualize the precise inner processes of molecular machines.  More...
05 Jan 2015
Image: 3BrPA (red) encased in a sugar-based microshell (Photo courtesy of Dr. Jean-Francois Geschwind, Johns Hopkins University).

New Packaging Revives Potential for Highly Toxic Cancer Drug

Cancer researchers have shown that sequestering the highly toxic drug 3-bromopyruvate in a sugar-based molecular microcapsule protects the drug from being inactivated in the bloodstream and eliminates the toxicity that prevents its general use as a chemotherapeutic agent.  More...
28 Dec 2014

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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