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Drug Discovery

Image: Wafers like the one shown here are used to create “organ-on-a-chip” devices to model human tissue (Photo courtesy of Dr. Anurag Mathur, University of California, Berkeley).

Human Heart-on-a-Chip Cultures May Replace Animal Models for Drug Development and Safety Screening

Human heart cells growing in an easily monitored silicon chip culture system may one day replace animal-based model systems for drug development and safety screening.  More...
22 Mar 2015

Two Proteins Critical for Circadian Cycles Protect Cells from Mutations

Scientists have discovered that two proteins critical for maintaining healthy day-night cycles also have an unexpected role in DNA repair and protecting cells against genetic mutations that could lead to cancer and other diseases.   More...
17 Mar 2015
Image: TEM (transmission electron micrograph) of a mesoporous silica nanoparticle (Photo courtesy of Wikimedia Commons).

Silica-Based Nanoparticles Selectively Kill Lung Cancer Cells

A novel approach to the selective delivery of toxic chemotherapeutic agents is based on nanoparticles that sequester the drug until it is liberated by the action of specific proteases that are present in a high concentration inside lung cancer cells.  More...
16 Mar 2015

Experimental Brain Cancer Drug Disrupts Intracellular Endosome Activity

Cancer researchers have described the mechanism by which the low molecular weight compound 5-Benzylglycinyl-amiloride disrupts the internal regulation of brain cancer cells in a manner that triggers the pathway for programmed cell death.   More...
16 Mar 2015

Protein Found That Complicates Healing from Respiratory Infections

A protein has been identified that slows healing of respiratory tissues and complicates recovery from diseases such as influenza and pneumonia.  More...
08 Mar 2015

Gold Nanotubes Are Novel Agents for Cancer Diagnosis and Treatment

Cancer researchers have produced a highly defined class of gold nanotubes that are suitable for use in animals as in vivo imaging nanoprobes, photothermal conversion agents, and drug delivery vehicles.  More...
03 Mar 2015

Double Targeting Approach Increases Potential for Cancer Treatment with Oncolytic Viruses

Cancer researchers have used a double targeting approach to direct oncolytic viruses specifically to tumor cells where they reproduce until the cancer cells burst, releasing more viruses to infect and ultimately destroy the tumor.  More...
02 Mar 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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