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Drug Discovery

Phage Lytic Enzyme Specifically Attacks MRSA

A novel bacteriophagic protein has been designed to attack methicillin-resistant Staphylococcus aureus (MRSA) microbes and dissolve them.  More...
01 Jul 2015
Image: Histological section of two mouse melanomas: (a) untreated and (b) treated with sitagliptin, a specific DPP4 inhibitor (Photo courtesy of Institut Pasteur).

Diabetes Drug Shows Promise as an Anticancer Immunotherapeutic Agent

Treatment with the anti-diabetes drug sitagliptin of some types of cancer in a mouse model was found to increase the infiltration of T lymphocytes into tumors and, in combination with existing immunotherapies, eradicate the tumor.   More...
30 Jun 2015
Image: Three dimensional rendering of the endoplasmic reticulum (Photo courtesy of Blausen Gallery 2014 via Wikimedia Commons).

Potential Diabetes Drug Works by Relieving Endoplasmic Reticulum Stress

A recent paper linked stress affecting the endoplasmic reticulum to the development of several chronic diseases including diabetes, retinitis pigmentosa, cystic fibrosis, Huntington's disease, and Alzheimer's disease.  More...
30 Jun 2015
Image: Micrograph showing a lymph node invaded by ductal breast carcinoma and with extranodal extension of tumor. The dark purple (center) is lymphocytes (part of a normal lymph node). Surrounding the lymphocytes and extending into the surrounding fat (top of image) is ductal breast carcinoma (Photo courtesy of Wikimedia Commons).

Antiangiogenic Drug Blocks Breast Cancer Metastasis in Mouse Models

Cancer researchers have identified a potential drug target in preclinical studies that by being blocked prevented breast cancer metastasis in several mouse models.  More...
24 Jun 2015
Image: Psoriasis plaques in the skin (Photo courtesy of Wikimedia Commons).

Clinical Trials Demonstrate Potential of New Psoriasis Drug

Two clinical trials involving the candidate psoriasis drug ixekizumab showed that it was more effective than the currently used drug etanercept or a placebo.  More...
22 Jun 2015
Image: After two hours, doxorubicin-carrying nanoparticles accumulated in cancer cells (red and yellow) in mice (left) and destroyed most of the tumor within a day (right) (Photo courtesy of the American Chemical Society).

Acid-Sensitive Nanoparticle Drug Delivery System Targets Cancer Stem Cells

A novel nanoparticle-based drug delivery system was designed to destroy the cancer stem cells that are responsible for tumor recurrence and development of drug resistance.  More...
22 Jun 2015
Image: False color scanning electron micrograph of Vibrio vulnificus bacteria (Photo courtesy of the CDC - [US] Centers for Disease Control and Prevention).

Bacterial Toxin Shows Promise as Potential Anticancer Drug

A toxin that increases the virulence of the bacteria that produce it shows promise as a potential anticancer agent.  More...
21 Jun 2015


The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
 
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