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Drug Discovery

Cell Biologists Find That Certain Mitochondrial Diseases Stem from Coenzyme Q10 Depletion

A team of German cell biologists has linked the development of certain mitochondrial-linked diseases to depletion of the organelles' pool of coenzyme Q10 brought about by mutation in the MFN2 gene, which encodes the fusion protein mitofusin 2.  More...
25 Feb 2015
Image: Molecular model of the protein Saposin C (Photo courtesy of Wikimedia Commons).

Nanovesicles Kill Human Lung Cancer Cells in Culture and in a Mouse Xenograft Model

Nanovesicles assembled from the protein Saposin C and the phospholipid dioleoylphosphatidylserine were shown to be potent inhibitors of lung cancer cells in culture and in a mouse xenograft model.  More...
24 Feb 2015
Image: The micrograph shows a multilayered three-dimensional \"organotypic\" platform for quantitative high-throughput screening to identify new therapeutics for ovarian cancer. Fibroblasts are red. Mesothelial cells are blue. Ovarian cancer cells are green. The square image is the XY-planes (up-down, right-left). The images on the sides are Z-planes (depth) (Photo courtesy of Lengyel laboratory, University of Chicago).

Culture-Based High Throughput Screen Detects Potent Anti-Ovarian Cancer Drugs

Cancer researchers have developed a high throughput system for screening drugs against ovarian tumors that is based on inhibition of cancer cells growing in a three-dimensional culture system.  More...
23 Feb 2015
Image: Eve, the robot scientist (Photo courtesy of the University of Manchester.

Robot Screening System Streamlines Discovery of New Drug Compounds

British drug developers have automated the drug discovery process by using a "robot scientist" to screen thousands of potential candidate compounds.  More...
23 Feb 2015
Image: Nanoparticles in low and high resolution micrographs (Photo courtesy of Green Laboratory, Johns Hopkins University).

Nanoparticles Deliver Viral Gene That Activates Toxic Drug Inside Brain Cancer Cells

Cancer researchers have described a nanoparticle-based gene therapy system that inserted the gene for the enzyme herpes simplex virus type I thymidine kinase into brain tumor cells and rendered them highly sensitive to the chemotherapeutic agent ganciclovir.  More...
17 Feb 2015

Mini-Organism-on-a-Chip May Replace Test Animals in Drug Studies

A team of German biomedical researchers has developed a highly miniaturized micro-circulatory system for testing the response of various body organs to drugs or other chemicals.  More...
16 Feb 2015
Image: Space-filling molecular model of epigallocatechin gallate (EGCG)(Photo courtesy of Wikimedia Commons).

Alternative Cancer Treatments May Be Based on Green Tea Components

A recent paper suggested that the green tea component epigallocatechin-3-gallate could be developed into an alternative treatment for oral cancer that would not have the severe side effects of current chemotherapeutic agents.   More...
10 Feb 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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