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Drug Discovery

Image: Left and right: Various species of Triatomine bugs, which if infected can transmit T. cruzi. Center: T. cruzi trypomastigote in a thin blood smear stained with Giemsa (Photo courtesy of the CDC).

Oral Nanocapsule Treatment Cures Mice with Chronic Phase Chagas Disease

Oral treatment with nanocapsules containing the Brazilian plant extract lychnopholide was shown to eradicate Trypanosoma cruzi in both the acute and chronic phases of Chagas disease. More...
30 Jun 2016

Structure of Enzyme for Trehalose Synthesis May Promote Drug Development

A team of molecular microbiologists has established the molecular structure of an enzyme required for synthesis of trehalose, a sugar required by several different pathogenic fungi. More...
29 Jun 2016
Image: A scanning electron microscope (SEM) image of methicillin-resistant Staphylococcus aureus bacteria (Photo courtesy of the CDC).

Drug Combination Cures MRSA Infection While Preventing Development of Resistance

Treatment with a combination comprising the well-known antibiotic cefdinir and the experimental drug TXA709 cured mice of drug-resistant staphylococcal infections while reducing the development of resistance. More...
23 Jun 2016

Tobacco Mosaic Virus Nanoparticle Delivery System Increases Potency of Experimental Anticancer Drug

A candidate anticancer drug was found to be considerably more potent than standard treatments and this potency was further increased in a mouse model when the drug was delivered by a tobacco mosaic virus (TMV)-based transport system. More...
20 Jun 2016

Custom Designed Peptides Transport Hydrophobic Drug Compounds

A bioengineering team has designed a novel class of drug-delivery peptides that coalesce into a hydrogel capable of transporting hydrophobic compounds within the hydrophobic cores of the peptide nanofibers. More...
20 Jun 2016

Aptamer Prevents Serpin Misfolding without Damaging Protease Inhibition

A team of Danish molecular biologists has developed an aptamer that blocks misfolding of mutant serpin protease inhibitors while maintaining the protein's inhibitory function. More...
20 Jun 2016
Image: The new active ingredient consists of DARPins (red and orange) that bend the HER2 receptors (blue) so no more growth signal is transmitted into the cell interior (below the cell membrane in yellow) (Photo courtesy of the University of Zurich).

Novel Class of Drugs Selectively Kills HER2-positive Breast Cancer Cells

A team of Swiss drug developers has designed a novel drug that cures breast cancer by completely blocking the activity of the surface receptor HER2 (human epidermal growth factor receptor 2). More...
16 Jun 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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