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Drug Discovery

Image: Cancer cells were treated with a control (left) and the overstimulating compound MCB-613 (right) (Photo courtesy of Dr. Lei Wang, Baylor University College of Medicine).

Drug Candidate Propels Cancer Cells into Fatal Overdrive

A candidate drug that destroys cancer cells by stimulating them to produce more proteins than the cells can actually process was shown to kill a wide variety of cancer cells in culture and to inhibit tumor growth in animal models.  More...
23 Aug 2015
Image: Molecular model of phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) (Photo courtesy of Wikimedia Commons).

Mutation Identified That Predicts Response of Breast Cancer to Treatment with Drug Duo

A gene mutation was identified as a biomarker that can predict whether a patient with HER-2 positive breast cancer will respond positively to the most effective dual anti-HER2 treatment.  More...
17 Aug 2015
Image: Transmission electron micrograph (TEM) of the newly repackaged pharmaceutical. The dark spots are the water-insoluble cores of the nanoparticles, while the peptide chains are barely visible due to their low electron density and high degree of hydration (Photo courtesy of Dr. Ashutosh Chilkoti, Duke University).

Nanoparticle-Bound Paclitaxel Outperforms Abraxane in Mouse Cancer Models

A novel formulation that intercalated the toxic cancer drug paclitaxel within inert nanoparticles increased the potency of the drug in mouse models while reducing the severity of its adverse side effects.  More...
16 Aug 2015

FDA Approves Rapid Dissolving Epilepsy Drug Produced by 3D Printing

A novel rapidly solubilized drug for treatment of epilepsy has become the first medication manufactured by a three-dimensional printing technique to be approved by the Food and Drug Administration.  More...
11 Aug 2015

Ready Source of Functional Liver Cells Should Boost Drug Development Efforts

Liver function in newborns kicks in only after exposure to certain nutrient factors derived from gut bacteria, and this phenomenon has been used to differentiate pluripotent stem cells into fully functional liver cells.   More...
09 Aug 2015

Modifying the Macrophage Microenvironment Reduces Tuberculosis Virulence

The virulence of the bacteria causing latent tuberculosis infections can be reduced by modifying the microenvironment inside the macrophages that host the pathogen.  More...
05 Aug 2015

Chimeric Drug Reduces Local Inflammation Without Causing General Immune Suppression

A novel anti-inflammatory drug is based on a chimeric molecule that avoids general immune suppression by being non-active when injected but is converted into an activate agent by leukocytes concentrated at the site of local inflammation.  More...
02 Aug 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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