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Drug Discovery

Image: The nano-cocoon drug delivery system is biocompatible, specifically targets cancer cells, can carry a large drug load, and releases the drugs very quickly once inside the cancer cell. Ligands on the surface of the \"cocoon\" trick cancer cells into consuming it. Enzymes (the “worms\" in this image) inside the cocoon are unleashed once inside the cell, destroying the cocoon and releasing anticancer drugs into the cell (Photo courtesy of Dr. Zhen Gu, North Carolina State University).

Novel Anticancer Drug Delivery System Utilizes DNA-Based Nanocapsules

A novel DNA-based drug delivery system minimizes damage to normal tissues by utilizing the acidic microenvironment inside cancer cells to trigger the directed release of the anticancer drug doxorubicin.  More...
26 Oct 2014

New Therapeutic Approach Floods Prostate Cancer Cells with Copper

A novel approach for treating prostate cancer is based on the co-administration of the drug disulfiram and copper, an element that the growing cancer cells require.  More...
26 Oct 2014

Molecule in Green Tea Used as Carrier for Anticancer Proteins

A molecule that is a key ingredient in green tea can be employed as a carrier for anticancer proteins, forming a stable and effective therapeutic nanocomplex. This new discovery could help to construct better drug-delivery systems.  More...
16 Oct 2014
Image: Microscope images of the bacteria P. acnes left untreated (A, B) or incubated for 24-hours (C, D) with resveratrol. Images were taken at 10,000 x magnification (A, C) or 29,000 x magnification (B, D) (Photo courtesy of the University of California, Los Angeles).

Combined Resveratrol and Benzoyl Peroxide Treatment Effectively Kills Acne Bacteria

A combination of the common acne medication benzoyl peroxide and the anti-oxidant resveratrol was found to be more effective in eradicating the bacteria responsible for acne than was benzoyl peroxide alone.  More...
15 Oct 2014
Image: Crystal structure of the immunoproteasome (Photo courtesy of the department of biochemistry, TUM).

Drug Development Advance for Treatment of Autoimmune Diseases, Chronic Inflammation Disorders

The immune system functions as the body’s protectors, defending it from intruders such as bacteria and viruses. However, to ascertain what is happening in the cell, the immune system requires information on the foreign invaders. This chore is taken on by protein complexes called immunoproteasomes. These are cylindrical complexes break down the protein structures of the intruders into fragments that can be used by the defense system.   More...
07 Oct 2014

MRI Technology Enables Noninvasive Monitoring of Emergent Cell Therapies

Cellular therapeutics, the application of using intact cells to treat and cure disease, is an important potential new therapeutic application, but it is hampered by the inability of clinicians and scientists to effectively monitor the destination, movements, and perseverance of these cells in patients without having to use invasive procedures, such as tissue sampling.   More...
07 Oct 2014

Protein Maps to Help Develop Powerful New Cancer Drugs

Chemical scientists have gained new insights into how a disease-causing enzyme makes changes to proteins and how to block it. The scientists hope their findings will help them to design drugs that could target the enzyme, known as N-myristoyltransferase, and potentially lead to new treatments for cancer and inflammatory conditions.   More...
06 Oct 2014

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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