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Drug Discovery

Image: A new micelle delivery system for the protective polyphenols resveratrol and quercetin (mRQ) may have value in cancer chemotherapy (Photo courtesy of Oregon State University).

Micelles Containing Resveratrol and Quercetin Reverse Doxorubicin Cardiotoxicity

Cancer researchers blocked the toxic effects of the cancer drug doxorubicin by administering it together with the plant antioxidants resveratrol and quercetin.  More...
28 Jul 2015

Advanced Genetic Tools Revamp Search for Drugs to Treat Cryptosporidium

Genetically engineered modifications to genome of the diarrhea-causing parasite Cryptosporidium are expected to expedite research towards vaccine and drug development to prevent or cure infection by this pathogen.  More...
28 Jul 2015
Image: The microneedle patch can dissolve in the skin, delivering the flu vaccine painlessly (Photo courtesy of Dr. Shinsaku Nakagawa, Osaka University).

Japanese Researchers Demonstrate Novel Transcutaneous Influenza Vaccination Using a Dissolving Microneedle Patch

Vaccination via a biodegradable microneedle patch was shown to generate immune response to various strains of the influenza virus that were equal to or stronger than those induced by traditional hypodermic needle injection.  More...
27 Jul 2015

Nanoparticle-Delivered siRNA Shrinks Tumors in Mouse Model

Cancer researchers employed a nanoparticle delivery system to deliver short interfering RNA that blocked the activity of Twist-related protein 1, which prevented growth and spread of tumors in a mouse model.  More...
20 Jul 2015

Low-Calorie Cranberry Juice Shown to Lower Cardiovascular Disease Risk

Supplementing the diet with low-calorie cranberry juice reduces the chances of developing cardiovascular disease by lowering several risk factors including circulating triglycerides, C-reactive protein, glucose, and diastolic blood pressure.  More...
14 Jul 2015

Relieving Endoplasmic Reticulum Stress May Prevent Some Types of Chronic Disease

A team of cell biologists has identified an enzyme that protects cells against endoplasmic reticulum stress and prevents the apoptosis that characterizes such chronic diseases as Wolfram syndrome, diabetes, heart disease, and Parkinson's disease.  More...
08 Jul 2015
Image: Scanning electron microscope (SEM) image of a field of polypyrrole nanowires (Photo courtesy of Dr. Richard Borgens, Purdue University).

Novel Controlled-Release Drug Delivery System Heals Spinal Inflammation in Mouse Model

A novel drug delivery system that allows controllable release of an anti-inflammatory agent directly to the site of inflammation or injury was tested successfully in a mouse model.  More...
06 Jul 2015

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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