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10 Oct 2016 - 12 Oct 2016
12 Nov 2016 - 16 Nov 2016

Drug Discovery

Novel Class of Nanoparticle Drug Transporters Selectively Target Lung Cancer Cells

A novel class of nanoparticles is able to deliver siRNA-based drugs selectively to lung cancer cells without harming normal cells. More...
26 Sep 2016

Inhibiting Enzyme Activity Overcomes Cell Differentiation Blockade

Inhibition of the enzyme dihydroorotate dehydrogenase (DHODH) was found to stimulate differentiation of acute myeloid leukemia (AML) cells, which reduced the cancer cell burden and promoted survival in human and mouse models. More...
26 Sep 2016

Snail Insulin Serves as Drug Development Model

A form of insulin isolated from a type of carnivorous marine snail lacks the segment of the B region that causes the protein to aggregate, which decreases the amount of time required by the hormone to influence glucose levels by a factor of three. More...
22 Sep 2016

Stabilizing Iron-Sulfur Transport Clusters Reduces Size and Aggressiveness of Tumors

An international team of cancer researchers has identified a protein that, when overexpressed, enabled breast tumors to better withstand oxidative stress thereby becoming much larger and more aggressive. More...
21 Sep 2016
Image: Ginger is the source of a novel class of nanolipid transport vector (Photo courtesy of Georgia State University).

Ginger-Derived Doxorubicin-Loaded Nanovectors as Drug Delivery for Cancer Therapy

A novel type of nanoparticle drug transport system based on lipids isolated from ginger was used to deliver the toxic chemotherapeutic agent doxorubicin (Dox) to colon cancer cells with minimal damage to normal tissues. More...
20 Sep 2016

Blocking Activity of Dopamine Receptor Impedes Growth and Spread of Pancreatic Cancer

Cancer researchers have found that a receptor protein that binds natural compounds such as dopamine and extraneous factors such as antipsychotic drugs to brain cells could inhibit the growth of pancreatic cancer and prevent it from metastasizing. More...
20 Sep 2016

Hormone Test May Reduce Rate of Teens Misdiagnosed with PCOS

Measuring blood levels of the recently discovered hormone irisin may improve accurate diagnosis rates of teenagers with polycystic ovary syndrome (PCOS) and so reduce the number of unnecessary treatments prescribed to healthy girls at an especially critical stage in their lives. More...
19 Sep 2016

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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