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11 Jun 2017 - 15 Jun 2017
19 Jun 2017 - 22 Jun 2017
New products on world’s medical product marketplace:

Drug Discovery

Image: Circulating white blood cells, commonly referred to as leukocytes (large yellow clusters), can be seen lining an inflamed vessel wall along with leukosomes (small yellow speckles). Leukosomes, designed to mimic white blood cells, go unnoticed as they accumulate at the inflamed vessel (purple background), allowing them to concentrate their therapeutic payload at the target site (Photo courtesy of Houston Methodist Hospital).

Study Explains How Drug Carriers Interact with Immune System

Researchers seeking to develop nanoparticle-based drug delivery systems have determined how a specialized class of nanoparticles called leukosomes avoids immune system response in a mouse model system. More...
20 Apr 2017
Image: Crystal structures of Mtb RNAP bound to rifampin (left) and Mtb RNAP bound to an AAP (right) show the Mtb RNAP interactions. Gray ribbons, Mtb RNAP backbone; gray, cyan, and green sticks, Mtb RNAP, rifampin, and AAP carbon atoms; red and blue sticks, oxygen and nitrogen atoms; green mesh, mFo-Fc electron density omit map; BH, Mtb RNAP bridge helix (Photo courtesy of Wei Lin and Richard H. Ebright, Rutgers University).

X-Ray Crystallography Findings Aid Discovery of New Drugs

Sensitive X-ray crystallography techniques were used to determine the three-dimensional (3D) molecular structure of the Mycobacterium tuberculosis enzyme RNA polymerase (Mtb RNAP) alone and when bound to the present first-line anti-tuberculosis drug rifampin. More...
18 Apr 2017
Image: The structure of Focal adhesion kinase (FAK) (Photo courtesy of Wikimedia Commons).

Cancer Growth Influenced by Myosin and FAK Protein Interaction

A team of cancer researchers has found that the interaction between the myosin and FAK (Focal adhesion kinase) proteins is critical to the ability of cancer cells to grow and spread to sites distant from that of the primary tumor. More...
13 Apr 2017
Image: The Crystal structure of PCSK9 (proprotein convertase subtilisin/kexin type 9) (Photo courtesy of Wikimedia Commons).

Cholesterol-Lowering Small RNA Drug Shows Promise in Early Trial

Results of a phase II, multicenter, double-blind, placebo-controlled, multiple-ascending-dose clinical trial confirmed that the experimental small interfering RNA (siRNA) drug inclisiran was effective for treating patients with elevated LDL cholesterol levels who were at high risk for developing cardiovascular disease. More...
12 Apr 2017
Image: Activation of the brain\'s fear network visualized using functional magnetic resonance imaging (MRI) (Photo courtesy of Dr. Tina Lonsdorf, Systems Neuroscience UKE Hamburg).

New Genetic Risk Factor Identified for Anxiety Disorders

Several newly discovered variants of the GLRB gene were associated with increased risk of developing anxiety disorders, including agoraphobic cognitions, increased startle response, and fear network activation, pointing to a potential neurogenetic pathway. More...
11 Apr 2017
Image: A genetic variant within the gene for protein tyrosine phosphatase receptor-type delta (PTPRD) has been associated to susceptibility to neurofibrillary tangles, which are thought to be more closely related to memory decline than other forms of aging-related brain pathologies (Photo courtesy of Rush University).

Gene Discovered Associated with Aging Brain Pathologies

Investigators have discovered a gene associated with susceptibility to the common Tau form of brain pathology that accumulates in several different conditions, including Alzheimer’s disease, certain forms of dementia, and Parkinsonian syndromes, as well as chronic traumatic encephalopathy that occurs with repeated head injuries. The gene and its product may serve as a marker for loss of brain function with advancing age, and as a potential drug therapy target. More...
04 Apr 2017
Image: Treatment with fusicoccin-A induces the regeneration of damaged axons towards the center of the injury. The axons are stained in green and the tips of the growing axons, called growth cones, are stained in red (Photo courtesy of McGill University).

Drugs Identified May Stimulate Axon Regeneration

A team of neurological science researchers has identified a class of small molecular growth promotors that may prove to be the basis for drugs designed to correct loss of axons following brain or nervous system injury or other disorders and diseases, including multiple sclerosis and neurodegenerative conditions. More...
21 Mar 2017

Product Showcase

The Drug Discovery channel in BioResearch informs about the biotechnology of drug discovery and design from traditional to translational pharma within the five-year horizon.
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