Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH PUBLISHING LLC
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC

Ventana Signs Companion Diagnostic Agreement for Genmab Antibody-Drug Conjugate

By BiotechDaily International staff writers
Posted on 14 Apr 2014
Ventana Medical Systems, Inc. (Ventana; Tucson, AZ, USA), a member of the Roche Group (Basel, Switzerland), has entered into an agreement with Genmab A/S (Copenhagen, Denmark) for the development of companion diagnostic (CDx) tools for Genmab's "HuMax-TF-ADC" antibody-drug conjugate (ADC) program. As part of the agreement, Ventana will provide its expertise and services towards the development of an immunohistochemistry (IHC) companion diagnostic test for the detection of tissue factor (TF) in patient tumor samples. The TF assay will be developed for possible designation as the screening test in clinical trials involving HuMax-TF-ADC.

CDx tests, designed to detect the presence of specific biomarkers, assist clinicians in selecting effective therapies and in identifying the patients most likely to respond favorably to specific therapies. Incorporating a companion diagnostic strategy into a drug development program may help generate more effective drugs with improved safety profiles for patients. Ventana has worked with more than 45 biopharmaceutical partners and is currently engaged in more than 180 collaborative projects to develop and commercialize companion diagnostics globally. The company has a global install base of over 10,000 automated platforms that run advanced cancer diagnostic tests.

Via antibody conjugation to potent cytotoxic drugs, ADCs for cancer therapy can increase efficacy and reduce systemic toxicity of drugs by targeting them selectively to tumor cells The targeted nature of ADCs make them good candidates for codevelopment with the Ventana IHC-based companion diagnostic assays that measure tumor-specific antigens.

"We are pleased to work with Genmab to develop a companion diagnostic for HuMax-TF-ADC," said Ventana President Mara G. Aspinall. "This agreement is in 100% alignment with our CDx strategy and our ever-growing lineup of global pharma partnerships designed to bring promising therapies to market faster to improve the lives of cancer patients."

Related Links:

Ventana Medical Systems
Genmab 
Roche



WATERS CORPORATION

Channels

Genomics/Proteomics

view channel
Image: Electron micrograph of Hepatitis C virus purified from cell culture. Scale bar is 50 nanometers (Photo courtesy of the Center for the Study of Hepatitis C, the Rockefeller University).

Oxidized LDL Predicts Response to Interferon Treatment of Chronic Hepatitis C and May Be a Treatment Option

Oxidized low-density lipoprotein (oxLDL) in the blood was shown to predict responsiveness to interferon treatment in patients with chronic Hepatitis C virus (HCV) infection and to inhibit spread of the... Read more

Drug Discovery

view channel
Image: Molecular model of the anti-cancer drug 5-fluorouracil (Photo courtesy of Wikimedia Commons).

Novel Microcapsule Approach Reduces Toxic Side Effects of Chemotherapy

Cancer researchers have reduced chemotherapy's toxic side effects by using nanoporous capsules to transport an enzyme to the site of a tumor where it is activated by a selective heating process to convert... Read more

Lab Technologies

view channel
Image: The gene assembly robot, the GeneTheatre (Photo courtesy of Analytik Jena AG).

Genomic Research Laboratories Await New Compact Liquid Handling System

A small footprint benchtop liquid handler that automates multiple gene assembly tasks and associated procedures such as PCR setup is now available for use by biotech and genomic research laboratories.... Read more

Business

view channel

NanoString and MD Anderson Collaborate on Development of Novel Multi-Omic Expression Profiling Assays for Cancer

The University of Texas MD Anderson Cancer Center (Houston, TX, USA) and NanoString Technologies, Inc. (Seattle, WA, USA) will partner on development of a revolutionary new type of assay—simultaneously profiling gene and protein expression, initially aiming to discover and validate biomarker signatures for immuno-oncology... Read more
 

Events

02 Jun 2015 - 03 Jun 2015
15 Jun 2015 - 18 Jun 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.