Features | Partner Sites | Information | LinkXpress
Sign In
JIB
GLOBETECH PUBLISHING
GLOBETECH PUBLISHING

Roche Acquires Rights to “Superbug” Antibiotic

By BiotechDaily International staff writers
Posted on 11 Nov 2013
Roche Holding (Basel, Switzerland) has agreed to pay as much as CHF 500 million (USD 548 million) to Polyphor (Allschwil, Switzerland) for the rights to an experimental antibiotic that targets drug-resistant Pseudomonas aeruginosa.

Under the terms of the agreement, Roche has received an exclusive worldwide license agreement to develop and commercialize Polyphor’s investigational macrocycle antibiotic, POL7080, for patients suffering from bacterial infections caused by Pseudomonas aeruginosa. Roche will make an upfront payment of CHF 35 million to Polyphor as well as payments upon reaching certain development, regulatory, and commercial milestones, potentially paying up to CHF 465 million. In addition, Polyphor is entitled to receive tiered double-digit royalties on product sales. Polyphor will also retain the option to co-promote an inhaled formulation of POL7080 in Europe.

Macrocycles are a unique drug class, typically with a molecular weight (Mw) of 400-2,000 and chemically defined by a ring structure, offering a promising alternative to small molecules and biopharmaceuticals due to their size, structure, stability, and specificity. While traditional small molecule drugs address only a fraction of the therapeutically relevant targets, it is believed that many of the new targets involve large surface protein-protein interactions (PPI). Polyphor’s technologies were specifically developed for discovering potent and selective modulators of PPI that cover an alternative molecular diversity space.

“As part of our infectious diseases research strategy we focus on areas of high unmet medical need, where we feel we can make the most difference for patients. We are excited to partner with Polyphor as we build a portfolio of novel antibiotics,” said Janet Hammond, head of Infectious Diseases Discovery & Translational Area at Roche. “As the incidence of drug-resistant infections is creating an urgent demand for new therapeutic options, we look forward to adding this potentially important, targeted agent with a novel mechanism of action to our portfolio of innovative medicines.”

“We are delighted about this license agreement. Roche is an ideal partner for POL7080, due to its long history of antibiotics development coupled with its strong scientific, clinical, and commercial capabilities,” said Jean-Pierre Obrecht, CEO and cofounder of Polyphor. “This agreement is also an important milestone for Polyphor, as it is a further validation of our macrocycle technologies and rewards more than 10 years of research and development efforts.”

Related Links:

Roche Holding
Polyphor



comments powered by Disqus

Channels

Genomics/Proteomics

view channel
Image: Differences in the structure of a small lung artery (top row) and heart cross section (lower row) of rodents without disease (far left column); with pulmonary hypertension (middle) and a diseased rodent treated with the HDL peptide (right). Note the much narrowed lung artery, and thick walls and larger chamber of the heart in the diseased animal and improvements with 4F peptide treatment (Photo courtesy of UCLA - University of California, Los Angeles).

Apolipoprotein A-1 Mimetic Peptide Reverses Pulmonary Hypertension in Rodent Models

A small peptide that mimics the activity of apolipoprotein A-1 (apo A-1), the main protein component of the high density lipoproteins (HDL), counteracted the effects of oxidized lipids and alleviated symptoms... Read more

Drug Discovery

view channel
Image: The five stages of biofilm development: (1) Initial attachment, (2) Irreversible attachment, (3) Maturation I, (4) Maturation II, and (5) Dispersion. Each stage of development in the diagram is paired with a photomicrograph of a developing P. aeruginosa biofilm. All photomicrographs are shown to same scale (Photo courtesy of Wikimedia Commons).

Ionic Liquids Disperse Bacterial Biofilms and Increase Antibiotic Susceptibility

The ionic liquid choline-geranate was shown to effectively eliminate the protective biofilm generated by bacteria such as Salmonella enterica and Pseudomonas aeruginosa and to significantly increase the... Read more

Therapeutics

view channel
Image: Hair follicle (blue) being attacked by T cells (green) (Photo courtesy of Christiano Lab/Columbia University Medical Center).

Hair Restoration Method Clones Patients’ Cells to Grow New Hair Follicles

Researchers have developed of a new hair restoration approach that uses a patient’s cells to grow new hair follicles. In addition, the [US] Food and Drugs Administration (FDA) recently approved a new drug... Read more

Lab Technologies

view channel
Image: Leica Microsystems launches the inverted research microscope platform Leica DMi8 (Photo courtesy of Leica Microsystems).

New Inverted Microscope Designed to Readily Adapt to Changing Research Demands

A new inverted microscope for biotech and other life science laboratories was designed to readily accommodate modifications and upgrades to allow it to keep current with changing research demands and interests.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.