Features | Partner Sites | Information | LinkXpress
Sign In
GLOBETECH MEDIA
GLOBETECH PUBLISHING LLC
GLOBETECH PUBLISHING LLC

Roche Acquires Rights to “Superbug” Antibiotic

By BiotechDaily International staff writers
Posted on 11 Nov 2013
Roche Holding (Basel, Switzerland) has agreed to pay as much as CHF 500 million (USD 548 million) to Polyphor (Allschwil, Switzerland) for the rights to an experimental antibiotic that targets drug-resistant Pseudomonas aeruginosa.

Under the terms of the agreement, Roche has received an exclusive worldwide license agreement to develop and commercialize Polyphor’s investigational macrocycle antibiotic, POL7080, for patients suffering from bacterial infections caused by Pseudomonas aeruginosa. Roche will make an upfront payment of CHF 35 million to Polyphor as well as payments upon reaching certain development, regulatory, and commercial milestones, potentially paying up to CHF 465 million. In addition, Polyphor is entitled to receive tiered double-digit royalties on product sales. Polyphor will also retain the option to co-promote an inhaled formulation of POL7080 in Europe.

Macrocycles are a unique drug class, typically with a molecular weight (Mw) of 400-2,000 and chemically defined by a ring structure, offering a promising alternative to small molecules and biopharmaceuticals due to their size, structure, stability, and specificity. While traditional small molecule drugs address only a fraction of the therapeutically relevant targets, it is believed that many of the new targets involve large surface protein-protein interactions (PPI). Polyphor’s technologies were specifically developed for discovering potent and selective modulators of PPI that cover an alternative molecular diversity space.

“As part of our infectious diseases research strategy we focus on areas of high unmet medical need, where we feel we can make the most difference for patients. We are excited to partner with Polyphor as we build a portfolio of novel antibiotics,” said Janet Hammond, head of Infectious Diseases Discovery & Translational Area at Roche. “As the incidence of drug-resistant infections is creating an urgent demand for new therapeutic options, we look forward to adding this potentially important, targeted agent with a novel mechanism of action to our portfolio of innovative medicines.”

“We are delighted about this license agreement. Roche is an ideal partner for POL7080, due to its long history of antibiotics development coupled with its strong scientific, clinical, and commercial capabilities,” said Jean-Pierre Obrecht, CEO and cofounder of Polyphor. “This agreement is also an important milestone for Polyphor, as it is a further validation of our macrocycle technologies and rewards more than 10 years of research and development efforts.”

Related Links:

Roche Holding
Polyphor



Channels

Genomics/Proteomics

view channel
Image: Transmission electron micrograph of norovirus particles in feces (Photo courtesy of Wikimedia Commons).

Norovirus Interacts with Gut Bacteria to Establish a Persistent Infection That Can Be Blocked by Interferon Lambda

A team of molecular microbiologists and virologists has found that norovirus requires an intimate interaction with certain gut bacteria to establish a persistent infection, and that the infective process... Read more

Biochemistry

view channel

Possible New Target Found for Treating Brain Inflammation

Scientists have identified an enzyme that produces a class of inflammatory lipid molecules in the brain. Abnormally high levels of these molecules appear to cause a rare inherited eurodegenerative disorder, and that disorder now may be treatable if researchers can develop suitable drug candidates that suppress this enzyme.... Read more

Therapeutics

view channel
Image: Cancer cells infected with tumor-targeted oncolytic virus (red). Green indicates alpha-tubulin, a cell skeleton protein. Blue is DNA in the cancer cell nuclei (Photo courtesy of Dr. Rathi Gangeswaran, Bart’s Cancer Institute).

Innovative “Viro-Immunotherapy” Designed to Kill Breast Cancer Cells

A leading scientist has devised a new treatment that employs viruses to kill breast cancer cells. The research could lead to a promising “viro-immunotherapy” for patients with triple-negative breast cancer,... Read more

Lab Technologies

view channel
Image: MIT researchers have designed a microfluidic device that allows them to precisely trap pairs of cells (one red, one green) and observe how they interact over time (Photo courtesy of Burak Dura, MIT).

New Device Designed to See Communication between Immune Cells

The immune system is a complicated network of many different cells working together to defend against invaders. Effectively combating an infection depends on the interactions between these cells.... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.